Cardiovascular effects of the post-COVID-19 condition – Nature.com

Posted: Published on January 19th, 2024

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Yuki, K., Fujiogi, M. & Koutsogiannaki, S. COVID-19 pathophysiology: a review. Clin. Immunol. 215, 108427 (2020).

Article CAS PubMed PubMed Central Google Scholar

Davis, H. E., McCorkell, L., Vogel, J. M. & Topol, E. J. Long COVID: major findings, mechanisms and recommendations. Nat. Rev. Microbiol. 21, 133146 (2023). This comprehensive review of long COVID highlights important underlying pathophysiology and includes detailed information on both cardiac and noncardiac effects of this condition.

Article CAS PubMed PubMed Central Google Scholar

Thaweethai, T. et al. Development of a definition of postacute sequelae of SARS-CoV-2 infection. JAMA https://doi.org/10.1001/jama.2023.8823 (2023).

Bonilla, H. et al. Therapeutic trials for long COVID-19: a call to action from the interventions taskforce of the RECOVER initiative. Front. Immunol. 14, 1129459 (2023).

Article CAS PubMed PubMed Central Google Scholar

Phetsouphanh, C. et al. Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nat. Immunol. 23, 210216 (2022).

Article CAS PubMed Google Scholar

Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J. & Prescott, H. C. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA 324, 782793 (2020).

Article CAS PubMed Google Scholar

Long, B. et al. Clinical update on COVID-19 for the emergency clinician: presentation and evaluation. Am. J. Emerg. Med. 54, 4657 (2022).

Article PubMed PubMed Central Google Scholar

Tsampasian, V. et al. Risk factors associated with post-COVID-19 condition: a systematic review and meta-analysis. JAMA Intern. Med. 183, 566580 (2023).

Article PubMed PubMed Central Google Scholar

Dessie, Z. G. & Zewotir, T. Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect. Dis. 21, 855 (2021).

Article CAS PubMed PubMed Central Google Scholar

Lundberg, D. J. et al. COVID-19 mortality by race and ethnicity in US metropolitan and nonmetropolitan areas, March 2020 to February 2022. JAMA Netw. Open 6, e2311098 (2023).

Article PubMed PubMed Central Google Scholar

Minhas, A. S. et al. The role of sex and inflammation in cardiovascular outcomes and mortality in COVID-19. Int. J. Cardiol. 337, 127131 (2021).

Article PubMed PubMed Central Google Scholar

Al-Aly, Z., Bowe, B. & Xie, Y. Long COVID after breakthrough SARS-CoV-2 infection. Nat. Med. 28, 14611467 (2022).

Article CAS PubMed PubMed Central Google Scholar

Tenforde, M. W. et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network - United States, MarchJune 2020. MMWR Morb. Mortal Wkly Rep. 69, 993998 (2020).

Article CAS PubMed PubMed Central Google Scholar

Hu, B., Guo, H., Zhou, P. & Shi, Z.-L. Characteristics of SARS-CoV-2 and COVID-19. Nat. Rev. Microbiol. 19, 141154 (2021).

Article CAS PubMed Google Scholar

Zaim, S., Chong, J. H., Sankaranarayanan, V. & Harky, A. COVID-19 and multiorgan response. Curr. Probl. Cardiol. 45, 100618 (2020).

Article PubMed PubMed Central Google Scholar

Sette, A. & Crotty, S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell 184, 861880 (2021).

Article CAS PubMed PubMed Central Google Scholar

Wong, K. et al. COVID-19 associated vasculitis: a systematic review of case reports and case series. Ann. Med. Surg. 74, 103249 (2022).

Article Google Scholar

Long, B., Brady, W. J., Koyfman, A. & Gottlieb, M. Cardiovascular complications in COVID-19. Am. J. Emerg. Med. 38, 15041507 (2020).

Article PubMed PubMed Central Google Scholar

Luo, W., Liu, X., Bao, K. & Huang, C. Ischemic stroke associated with COVID-19: a systematic review and meta-analysis. J. Neurol. 269, 17311740 (2022).

Article CAS PubMed Google Scholar

World Health Organization. A clinical case definition of post-COVID-19 condition by a Delphi consensus. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1 (2021).

Xie, Y., Xu, E., Bowe, B. & Al-Aly, Z. Long-term cardiovascular outcomes of COVID-19. Nat. Med. 28, 583590 (2022). This unique article utilized a large national database to highlight the heightened risk of several cardiovascular complications following COVID-19 infection, which helps frame the importance of a solid knowledge base in this topic for healthcare providers.

Gluckman, T. J.et al. 2022 ACC Expert Consensus Decision Pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play: a report of the American College of Cardiology Solution Set Oversight Committee. J. Am. Coll. Cardiol. 79, 17171756 (2022). This important expert consensus document discusses different phenotypes of post-COVID-19 condition cardiovascular disease and provides recommendations on screening for myocardial involvement.

Article PubMed Google Scholar

Khan, M. S. et al. Cardiovascular implications of COVID-19 versus influenza infection: a review. BMC Med. 18, 403 (2020).

Article CAS PubMed PubMed Central Google Scholar

Chimenti, C. et al. Intramyocyte detection of EpsteinBarr virus genome by laser capture microdissection in patients with inflammatory cardiomyopathy. Circulation 110, 35343539 (2004).

Article CAS PubMed Google Scholar

Deumer, U.-S. et al. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): an overview. J. Clin. Med. 10, 4786 (2021).

Article CAS PubMed PubMed Central Google Scholar

Zheng, Y. -Y., Ma, Y. -T., Zhang, J. -Y. & Xie, X. COVID-19 and the cardiovascular system. Nat. Rev. Cardiol. 17, 259260 (2020).

Article CAS PubMed PubMed Central Google Scholar

Raman, B., Bluemke, D. A., Lscher, T. F. & Neubauer, S. Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus. Eur. Heart J. 43, 11571172 (2022).

Article CAS PubMed PubMed Central Google Scholar

Bonaventura, A. et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat. Rev. Immunol. 21, 319329 (2021).

Article CAS PubMed PubMed Central Google Scholar

Beyerstedt, S., Casaro, E. B. & Rangel, . B. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur. J. Clin. Microbiol. Infect. Dis. 40, 905919 (2021).

Article CAS PubMed PubMed Central Google Scholar

Pretorius, E. et al. Persistent clotting protein pathology in long COVID/post-acute sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. Cardiovasc. Diabetol. 20, 172 (2021).

Article CAS PubMed PubMed Central Google Scholar

Osiaevi, I. et al. Persistent capillary rarefication in long COVID syndrome. Angiogenesis 26, 5361 (2023).

Article CAS PubMed Google Scholar

Patel, M. A. et al. Elevated vascular transformation blood biomarkers in long-COVID indicate angiogenesis as a key pathophysiological mechanism. Mol. Med. 28, 122 (2022).

Article CAS PubMed PubMed Central Google Scholar

Proal, A. D. & VanElzakker, M. B. Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms. Front. Microbiol. 12, 698169 (2021).

Article PubMed PubMed Central Google Scholar

Naveed, Z. et al. Association of COVID-19 infection with incident diabetes. JAMA Netw Open 6, e238866 (2023).

Article PubMed PubMed Central Google Scholar

Mohiuddin Chowdhury, A. T. M. et al. Clinical characteristics and the long-term post-recovery manifestations of the COVID-19 patientsa prospective multicenter cross-sectional study. Front. Med. 8, 663670 (2021).

Article Google Scholar

Gyngysi, M. et al. Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases. Cardiovasc. Res. 119, 336356 (2023). This is a thorough Scientific Statement describing long COVID epidemiology, diagnosis, pathophysiology, and management with specific emphasis on the cardiovascular system.

Article PubMed Google Scholar

Miglis, M. G. et al. A case report of postural tachycardia syndrome after COVID-19. Clin. Auton. Res. 30, 449451 (2020).

Article PubMed PubMed Central Google Scholar

Kanjwal, K., Jamal, S., Kichloo, A. & Grubb, B. P. New-onset postural orthostatic tachycardia syndrome following coronavirus disease 2019 infection. J. Innov. Card. Rhythm Manag. 11, 43024304 (2020).

Article PubMed PubMed Central Google Scholar

Ishibashi, Y., Yoneyama, K., Tsuchida, T. & Akashi, J. Y. Post-COVID-19 postural orthostatic tachycardia syndrome. Intern. Med. 60, 2345 (2021).

Article PubMed PubMed Central Google Scholar

OSullivan, J. S., Lyne, A. & Vaughan, C. J. COVID-19-induced postural orthostatic tachycardia syndrome treated with ivabradine. BMJ Case Rep. 14, e243585 (2021).

Article PubMed PubMed Central Google Scholar

Schofield, J. R. Persistent antiphospholipid antibodies, mast cell activation syndrome, postural orthostatic tachycardia syndrome and post-COVID syndrome: 1 year on. Eur. J. Case Rep. Intern. Med. 8, 002378 (2021).

PubMed PubMed Central Google Scholar

Johansson, M. et al. Long-haul post-COVID-19 symptoms presenting as a variant of postural orthostatic tachycardia syndrome: the Swedish experience. JACC Case Rep. 3, 573580 (2021).

Article PubMed PubMed Central Google Scholar

Blitshteyn, S. & Whitelaw, S. Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infection: a case series of 20 patients. Immunol. Res. 69, 205211 (2021).

Article CAS PubMed PubMed Central Google Scholar

Bosco, J. & Titano, R. Severe post-COVID-19 dysautonomia: a case report. BMC Infect. Dis. 22, 214 (2022).

Article CAS PubMed PubMed Central Google Scholar

Wallukat, G. et al. Functional autoantibodies against G-protein-coupled receptors in patients with persistent long-COVID-19 symptoms. J. Transl. Autoimmun. 4, 100100 (2021).

Article CAS PubMed PubMed Central Google Scholar

Buoite Stella, A. et al. Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study. J. Neurol. 269, 587596 (2022).

Article CAS PubMed Google Scholar

Shouman, K. et al. Autonomic dysfunction following COVID-19 infection: an early experience. Clin. Auton. Res. 31, 385394 (2021).

Article PubMed PubMed Central Google Scholar

Campen, C. L. M. C., van, Rowe, P. C. & Visser, F. C. Orthostatic symptoms and reductions in cerebral blood flow in long-haul COVID-19 patients: similarities with myalgic encephalomyelitis/chronic fatigue syndrome. Medicina 58, 28 (2021).

Article PubMed Google Scholar

Novak, P. et al. Multisystem involvement in post-acute sequelae of coronavirus disease 19. Ann. Neurol. 91, 367379 (2022).

Article CAS PubMed PubMed Central Google Scholar

Jamal, S. M. et al. Prospective evaluation of autonomic dysfunction in post-acute sequela of COVID-19. J. Am. Coll. Cardiol. 79, 23252330 (2022).

Article PubMed PubMed Central Google Scholar

Eldokla, A. M. & Ali, S. T. Autonomic function testing in long-COVID syndrome patients with orthostatic intolerance. Auton. Neurosci. 241, 102997 (2022).

Article CAS PubMed Google Scholar

Campen, C. L. M. Cvan & Visser, F. C. Long-haul COVID patients: prevalence of POTS are reduced but cerebral blood flow abnormalities remain abnormal with longer disease duration. Healthcare 10, 2105 (2022).

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Cardiovascular effects of the post-COVID-19 condition - Nature.com

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