MONDAY, Feb. 25 (HealthDay News) -- Diabetes patients who take the latest class of drugs to control blood sugar levels are twice as likely to develop pancreatitis as those who take other medications to control blood sugar, according to a new study.
The drugs Januvia (sitagliptin) and Byetta (exenatide) are glucagon-like peptide-1-based (GLP-1) therapies, which are used by millions of Americans with diabetes.
Pancreatitis is inflammation of the pancreas, the organ that releases hormones such as insulin and glucagon, as well as enzymes that help digest food. Pancreatitis is a painful condition that can be dangerous if left untreated. People with diabetes are already at higher risk for pancreatitis because of the role the pancreas plays in the condition.
In this study, researchers from Johns Hopkins University in Baltimore compared nearly 1,300 type 2 diabetes patients who took one of the GLP-1 drugs with the same number of type 2 diabetes patients who took other medications. Those who took the GLP-1 drugs were twice as likely to be hospitalized with acute pancreatitis within 60 days of first taking the drugs than the other group of patients.
The GLP-1 drugs appeared to affect the pancreas in ways that trigger inflammation, according to the study, which was published online Feb. 25 in the journal JAMA Internal Medicine.
Doctors and government regulators have known that pancreatitis could be a side effect of GLP-1 drugs, a risk that was noted in animal studies and reported to the U.S. Food and Drug Administration. The researchers said their study is the first to accurately assess the degree of risk in humans. While their findings showed an association between the drugs and pancreatitis, they did not prove a cause-and-effect link.
"These agents are used by millions of Americans with diabetes. These new diabetes drugs are very effective in lowering blood glucose," study leader Dr. Sonal Singh, an assistant professor in the division of general internal medicine at the Johns Hopkins University School of Medicine, said in a university news release. "However, important safety findings may not have been fully explored, and some side effects such as acute pancreatitis don't appear until widespread use after approval."
Patients taking GLP-1 drugs should know about the symptoms of pancreatitis -- abdominal pain, nausea and persistent vomiting -- and seek immediate treatment if these symptoms occur, the researchers said.
Another expert added some additional caveats.
"Physicians need to be aware of these problems and discuss risks versus benefits with their patients," said Dr. Abayomi Akanji, a professor in medical sciences at the Frank H. Netter MD School of Medicine at Quinnipiac University, in Connecticut. "Of course, these drugs are not recommended to be prescribed to children, pregnant women and maybe nursing mothers. They should also preferably be avoided in individuals with poor liver or kidney function, or who are hypersensitive to the medication."
Original post:
Newest Diabetes Drugs Linked to Higher Pancreatitis Risk
- Free Download MP3 Album Destroy Rebuild Until God Shows - DRUGS [Last Updated On: February 17th, 2011] [Originally Added On: February 17th, 2011]
- Free Download MP3 Album Designer Drugs - Hardcore/ Softcore [Last Updated On: February 23rd, 2011] [Originally Added On: February 23rd, 2011]
- Destroy Rebuild Until God Shows - "If You Think This Song Is About You..." [OFFICIAL VIDEO] [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Drugs Make You Ugly [Last Updated On: May 7th, 2011] [Originally Added On: May 7th, 2011]
- Bill Cosby Drugs [Last Updated On: May 9th, 2011] [Originally Added On: May 9th, 2011]
- Spiders On Drugs [Last Updated On: May 10th, 2011] [Originally Added On: May 10th, 2011]
- Ali-G Drugs [Last Updated On: May 19th, 2011] [Originally Added On: May 19th, 2011]
- 10 Celebrities Caught on Tape with Drugs [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- Black Lips "Drugs" [Last Updated On: May 20th, 2011] [Originally Added On: May 20th, 2011]
- Hallucinate without the use of drugs, watch this [Last Updated On: May 24th, 2011] [Originally Added On: May 24th, 2011]
- Phil On Drugs..... [Last Updated On: May 30th, 2011] [Originally Added On: May 30th, 2011]
- Weezer - We Are All On Drugs [Last Updated On: May 31st, 2011] [Originally Added On: May 31st, 2011]
- Röyksopp - The Drug (Official Video) [Last Updated On: June 1st, 2011] [Originally Added On: June 1st, 2011]
- Anti-Drug Dog [Last Updated On: June 1st, 2011] [Originally Added On: June 1st, 2011]
- Drug problems [Last Updated On: June 3rd, 2011] [Originally Added On: June 3rd, 2011]
- Surfers: Iron's Drug Use Is A Let Down [Last Updated On: June 9th, 2011] [Originally Added On: June 9th, 2011]
- Betty Boop Cartoon Banned For Drug Use 1934 [Last Updated On: June 13th, 2011] [Originally Added On: June 13th, 2011]
- Ke$ha - Your Love Is My Drug [Last Updated On: June 17th, 2011] [Originally Added On: June 17th, 2011]
- Cokemobile: Video of insane armored drug truck used by Mexico cartels [Last Updated On: June 18th, 2011] [Originally Added On: June 18th, 2011]
- Love and Other Drugs Movie Trailer Official (HD) [Last Updated On: June 25th, 2011] [Originally Added On: June 25th, 2011]
- Ron Paul on legalizing drugs and gay marriage - SC Republican debate 5/5/2011 [Last Updated On: June 30th, 2011] [Originally Added On: June 30th, 2011]
- lil kim drugs [Last Updated On: July 6th, 2011] [Originally Added On: July 6th, 2011]
- Growing Number Of Vets Becoming Hooked On Drugs [Last Updated On: July 13th, 2011] [Originally Added On: July 13th, 2011]
- 'Bush, Reagan let drugs flow free to US from Nicaragua' - ex-dealer [Last Updated On: July 14th, 2011] [Originally Added On: July 14th, 2011]
- Drug taken by White before crash can impair vision [Last Updated On: July 15th, 2011] [Originally Added On: July 15th, 2011]
- Graveyard Dancing - DRUGS (Lyrics) [Last Updated On: July 16th, 2011] [Originally Added On: July 16th, 2011]
- War on Drugs: The Globalists Biggest Ponzi Scheme of All Time! - Alex Jones Tv Sunday Edition 2/2 [Last Updated On: July 17th, 2011] [Originally Added On: July 17th, 2011]
- The Shadow GOV deals the drugs [Last Updated On: July 17th, 2011] [Originally Added On: July 17th, 2011]
- Ohio Medicaid Russian Drug Smuggling Investigation [Last Updated On: July 20th, 2011] [Originally Added On: July 20th, 2011]
- Homemade drugs devastating Russian addicts [Last Updated On: July 23rd, 2011] [Originally Added On: July 23rd, 2011]
- Report: War On Drugs Has Failed [Last Updated On: July 24th, 2011] [Originally Added On: July 24th, 2011]
- Drug trafficking for 'justice' in Mexico [Last Updated On: July 25th, 2011] [Originally Added On: July 25th, 2011]
- Inside Story - Has the global war on drugs failed? [Last Updated On: July 25th, 2011] [Originally Added On: July 25th, 2011]
- War on Drugs: The Globalists Biggest Ponzi Scheme of All Time! - Alex Jones Sunday Edition 1/2 [Last Updated On: July 26th, 2011] [Originally Added On: July 26th, 2011]
- The Cost of the War on Drugs [Last Updated On: July 27th, 2011] [Originally Added On: July 27th, 2011]
- Joe Rogan - Marijuana the Gateway Drug [Last Updated On: August 2nd, 2011] [Originally Added On: August 2nd, 2011]
- Get Personal: Drugs [Last Updated On: August 5th, 2011] [Originally Added On: August 5th, 2011]
- Watching Daughter on Drugs [Last Updated On: August 10th, 2011] [Originally Added On: August 10th, 2011]
- Elite troops take sides in Mexican drugs wars [Last Updated On: August 17th, 2011] [Originally Added On: August 17th, 2011]
- Amy Winehouse on Drugs (Belgrade Live 2011) [Last Updated On: August 18th, 2011] [Originally Added On: August 18th, 2011]
- Fake War on Drugs: US Government is The Real Kingpin - Alex Jones Tv 1/2 [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- Destroy Rebuild Until God Shows - Sex Life (Video) [Last Updated On: August 19th, 2011] [Originally Added On: August 19th, 2011]
- Falling In Reverse - "The Drug In Me Is You" [Last Updated On: August 22nd, 2011] [Originally Added On: August 22nd, 2011]
- Drug Tunnel [Last Updated On: August 27th, 2011] [Originally Added On: August 27th, 2011]
- Runescape on Drugs [Last Updated On: September 1st, 2011] [Originally Added On: September 1st, 2011]
- California On Drugs [Last Updated On: September 4th, 2011] [Originally Added On: September 4th, 2011]
- The War On Drugs- Slave Ambient ALBUM REVIEW [Last Updated On: September 6th, 2011] [Originally Added On: September 6th, 2011]
- Kids don't do drugs... [Last Updated On: September 10th, 2011] [Originally Added On: September 10th, 2011]
- Don't Do Drugs [Last Updated On: September 11th, 2011] [Originally Added On: September 11th, 2011]
- Drug Commercial (Jon Lajoie) [Last Updated On: September 14th, 2011] [Originally Added On: September 14th, 2011]
- Australian Story Love and Other Drugs P2 [Last Updated On: September 24th, 2011] [Originally Added On: September 24th, 2011]
- Losing the 'War on Drugs' [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- Alternate Reality! Drugs! Science! [Last Updated On: September 25th, 2011] [Originally Added On: September 25th, 2011]
- The War on Drugs Has Failed [Last Updated On: September 28th, 2011] [Originally Added On: September 28th, 2011]
- End The Failed War On Drugs - Cenk on MSNBC [Last Updated On: September 29th, 2011] [Originally Added On: September 29th, 2011]
- Deus Ex: Human Revolution - Part 8: Drugs are bad m'kay [Last Updated On: September 30th, 2011] [Originally Added On: September 30th, 2011]
- Mike Posner - Drug Dealer Girl [Last Updated On: October 3rd, 2011] [Originally Added On: October 3rd, 2011]
- CIA Drug Ops Conspiracy-Unaired Documentary-Full Length [Last Updated On: October 6th, 2011] [Originally Added On: October 6th, 2011]
- People [Last Updated On: October 9th, 2011] [Originally Added On: October 9th, 2011]
- OSHO: About Drugs [Last Updated On: October 10th, 2011] [Originally Added On: October 10th, 2011]
- Drug Testing All College Students [Last Updated On: October 10th, 2011] [Originally Added On: October 10th, 2011]
- The Verve - The Drugs Don't Work [Last Updated On: October 13th, 2011] [Originally Added On: October 13th, 2011]
- Android dance, bugged robot on drugs ! - Video [Last Updated On: October 17th, 2011] [Originally Added On: October 17th, 2011]
- Iggy Azalea ft. YG 400 - DRUGS - Video [Last Updated On: October 17th, 2011] [Originally Added On: October 17th, 2011]
- A Nation On Drugs - Yemen - Video [Last Updated On: October 18th, 2011] [Originally Added On: October 18th, 2011]
- Eminem Drug Ballad - Video [Last Updated On: October 20th, 2011] [Originally Added On: October 20th, 2011]
- American Drug War: The Last White Hope: Pre Release Cut - Video [Last Updated On: October 23rd, 2011] [Originally Added On: October 23rd, 2011]
- The War On Drugs - "Baby Missiles" (Official Video) - Video [Last Updated On: October 24th, 2011] [Originally Added On: October 24th, 2011]
- Nine Inch Nails - The Perfect Drug (full) - 480p - Video [Last Updated On: October 28th, 2011] [Originally Added On: October 28th, 2011]
- DRUGS - Video [Last Updated On: October 30th, 2011] [Originally Added On: October 30th, 2011]
- Drugs, drugs, drugs! - Video [Last Updated On: November 3rd, 2011] [Originally Added On: November 3rd, 2011]
- World's Most Dangerous Drug - Video [Last Updated On: November 5th, 2011] [Originally Added On: November 5th, 2011]
- "The War on Drugs" explained by Graham Hancock - The Joe Rogan Experience - Video [Last Updated On: November 6th, 2011] [Originally Added On: November 6th, 2011]
- I Don't Like The Drugs (But The Drugs Like Me) - Video [Last Updated On: November 7th, 2011] [Originally Added On: November 7th, 2011]
- Hockey plane crash: Drugs and bad braking - Video [Last Updated On: November 9th, 2011] [Originally Added On: November 9th, 2011]
- Bill Hicks - Positive Drug Story - Video [Last Updated On: November 10th, 2011] [Originally Added On: November 10th, 2011]
- The Worst Anti-Drug Movie Ever - Video [Last Updated On: November 12th, 2011] [Originally Added On: November 12th, 2011]
- Huffington Post Honored for Drug Policy Coverage - Video [Last Updated On: November 13th, 2011] [Originally Added On: November 13th, 2011]
- NOFX - Drugs Are Good - Video [Last Updated On: November 16th, 2011] [Originally Added On: November 16th, 2011]
- DRUGS playing "Sex Life" in Detroit, MI - Video [Last Updated On: November 17th, 2011] [Originally Added On: November 17th, 2011]