Jeff Schloss: Sequencing the human genome to promote health and understand disease
spie.org - the worlds largest biophotonics conference, SPIE BiOS at Photonics West As the costs come down, researchers will be able to learn about the correlations between genome sequences and health. In 2004, the National Human Genome Research Institute, part of the National Institutes of Health, launched an ambitious program of research to reduce the cost of sequencing the human genome -- all of the DNA in the nucleus of the cells in our bodies -- from $10 million to about $1000. Lopping 4 zeros off of the cost of a process requires tremendous creativity and risk-taking. Research supported by NHGRI, performed in academic and industry labs, is being complemented by the substantial investment that enables aggressive research and commercialization programs by a number of companies. The outcome has been a remarkable reduction in the cost of sequencing and explosion in the availability, in databases, of tens of thousands of human genome sequences, enabling research to understand the contribution of changes in genome sequence to a variety of diseases that take such a toll on the human population. These low-cost sequencing methods are also being used to understand the role of the microbes that naturally live on and in our bodies and strongly influence our health, as well as to improve the qualities of crops and livestock. Costs appear likely to approach the $1000 goal over the next year, and sequence quality, already good, continues to improve. Versions of these systems are ...From:SPIETVViews:8 0ratingsTime:07:28More inScience Technology
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Jeff Schloss: Sequencing the human genome to promote health and understand disease - Video