Recent Evidence Suggests Potential Role of Inflammation in Epilepsy
SAN DIEGO andWASHINGTON, Dec. 3, 2012 /PRNewswire-USNewswire/ -- The Epilepsy Therapy Project (ETP) and the Epilepsy Foundation (EF) today announced that Harbor Therapeutics, Inc. (HRBR.OB), a San Diego-based biopharmaceutical company, is the latest grant recipient of their New Therapy Grants Program, a unique joint venture of the two non-profit epilepsy organizations to advance clinical development and commercialization of promising epilepsy therapies. The grant will support the preclinical development of Harbor Therapeutic' s anti-inflammatory drug HE3286 in drug-resistant epilepsy. HE3286 is currently in Phase II clinical trials for diabetes. The award was announced by the Epilepsy Therapy Project and the Epilepsy Foundation during the American Epilepsy Society (AES) 66th Annual Meeting in San Diego, CA.
Brain inflammation is linked to epilepsy including drug resistant seizures, and specific anti-inflammatory drugs have been able to suppress ongoing seizures in animal models of chronic epilepsy.[1] HE3286 is an orally bioavailable, blood-brain-barrier permeable anti-inflammatory compound that is being repurposed for epilepsy. The anti-inflammatory action of HE3286 demonstrated in several different inflammatory disease modelsincluding Parkinson's disease and multiple sclerosisprovides a strong rationale for its evaluation in epilepsy.
ETP's Scientific Advisory Board and Business Advisory Board, which evaluated all grant applications, were enthusiastic about the project, entitled HE3286 Treatment of Drug Resistant Epilepsy,and awarded funding of more than $60,000 to Harbor Therapeutics for the proposal submitted by Clarence Ahlem, Vice President of Product Development (cahlem@harbortx.com, http://www.harbortx.com).The specific study to be performed will be a preclinical study in chronic seizures in micespecifically in a model that captures the complex chronic inflammatory interactions which have been shown to be targeted by the mechanism of action of this compound in other disease models. The study will be performed by Annamaria Vezzani, PhD, Head of the Laboratory of Experimental Neurology at the world-renowned Mario Negri Institute for Pharmacological Research, Milan, Italy.Dr. Vezzani maintains one of the few laboratories in the world with significant experience in this mouse model of chronic epilepsy.The proposed experiments in mice will be completed within one year of the grant award.
"Through the New Therapy Grants award program we seek to support important new products with the potential to provide significant benefit to people currently living with epilepsy," said Roger J. Porter, MD, Chief Scientific Officer, Epilepsy Therapy Project. "Harbor Therapeutic's project is particularly compelling because HE3286 is already in Phase II clinical trials for type 2 diabetes and it is well positioned for rapid entry into epilepsy clinical trials if found active in the proposed epilepsy proof of concept studies."
Chronic safety and pharmaceutical acceptability studies for HE3286 are complete; the drug has an excellent safety profile and good pharmaceutical characteristics.
About The New Therapy Grants ProgramThe New Therapy Grants Program is a unique joint venture between two non-profit epilepsy organizations, The Epilepsy Therapy Project and the Epilepsy Foundation. Grants are awarded to support programs that demonstrate promise as new treatments through critical early clinical milestones and readiness for further investment and development. Applications are evaluated by professional scientific and business advisory board members. Awards are given based on the potential to provide substantial benefit in a timeframe relevant to those living with epilepsy today. To date, close to 60 grants have been awarded for the advancement of new therapeutics and devices that have demonstrated a more rapid path to benefiting patients and future commercialization.
For a comprehensive list of all epilepsy therapies in development including past projects supported by the New Therapy Grants program, please visit http://www.epilepsy.com/etp/pipeline_new_therapies.The epilepsy pipeline identifies the most promising products from early-stage development to commercial-stage, and whether a product is currently available in the US or internationally.
Upcoming Grant Applicants: Note Deadline for Letter of Intent is March 1, 2013The New Therapy Grants Program is requesting proposals from scientific and clinical investigators pursuing innovative projects that demonstrate a clear path to commercialization. The program accepts the submission of proposals ranging from $50,000 to $500,000. The deadline to submit a Letter of Intent (LOI) is March 1, 2013. If LOI is selected for full proposal, submissions are due April 17, 2013. To apply or view additional requirements, visit http://www.epilepsy.com/etp/support_translational.
About Epilepsy When a person has two or more unprovoked seizures, they have epilepsy, which affects nearly 3 million people in the United States and 50 million people worldwide. This year, another 200,000 people in our country will be diagnosed with epilepsy. Despite all available treatments, 30 to 40% of people with epilepsy continue to experience seizures.
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Epilepsy Organizations Award Grant To Harbor Therapeutics To Study Anti-Inflammatory Drug In Epilepsy