New stem cell technique may aid medical treatments

By MALCOLM RITTER/AP Science Writer/January 29, 2014

NEW YORK (AP) A simple lab treatment can turn ordinary cells from mice into stem cells, according to a surprising study that hints at a possible new way to grow tissue for treating illnesses like diabetes and Parkinsons disease.

Researchers in Boston and Japan exposed cells from spleens of newborn mice to a more acidic environment that theyre used to. In lab tests, that turned them into stem cells, showing enough versatility to produce the tissues of a mouse embryo, for example.

Cells from skin, muscle, fat and other tissue of newborn mice appeared to go through the same change, which could be triggered by exposing cells to any of a variety of stressful situations, researchers said.

Scientists hope to harness stem cells to replace defective tissue in a wide variety of diseases. By making stem cells from the patient, they can get around the problem of transplant rejection.

Human cells are now routinely turned into so-called iPS stem cells. That involves reprogramming an ordinary cell by slipping genes or substances into its nucleus. The new method, in contrast, lets the cell change its own behavior after researchers have applied an external stress.

Its very simple to do. I think you could do this actually in a college lab, said Dr. Charles Vacanti of Brigham and Womens Hospital in Boston, an author of two papers published online Wednesday by the journal Nature.

Vacanti also acknowledged that if the technique works with human cells, it could conceivably provide a new potential route for cloning people. He has no interest in doing that, he said, but it is a concern.

Another author, Haruko Obokata of the RIKEN Center for Developmental Biology in Kobe, Japan, said researchers are now studying whether the technique works with human cells. She also said its premature to compare it to iPS technology in terms of potential medical uses.

Experts not connected to the study said the results are surprising, and that its too soon to know their practical implications.

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New stem cell technique may aid medical treatments