Learn About Multiple Sclerosis – Treatments for Multiple …

Treatments for Multiple Sclerosis

Treatment options for MS have changed dramatically since 1993, when the first disease-modifying drug, Betaseron, became commercially available. Currently, there are 10 FDA-approved disease-modifying drugs for MS: Aubagio, Avonex, Betaseron, Copaxone, Extavia, Gilenya, Novantrone, Rebif, Tecfidera. and Tysabri. These drugs are not a cure for MS. However, treatment with these drugs can alter the course of the disease by decreasing the number and severity of relapses, by slowing the progression of the disease, and by reducing the accumulation of new lesions.

Avonex, Betaseron, Extavia, Copaxone and Rebif are generally considered to be first-line therapies in the treatment of MS. While Novantrone is indicated for worsening and progressive forms of MS, it is rarely used due to a high incidence of leukemia and a higher than expected rate of cardiac dysfunction. (Since Novantrone is rarely prescribed, it will not be discussed further in this article.)

MS Treatment Guidelines

Research demonstrates that potentially irreversible axonal damage may occur early in relapsing-remitting MS. These therapies appear to be more effective in preventing new lesions than in repairing old lesions. Based on these findings, it is the consensus of researchers and clinicians with expertise in MS that the following treatment guidelines be followed:

Therapy with a disease-modifying drug should be initiated as early in the disease course as possible. Such treatment may also be considered for those who have experienced a first attack and are at high risk of developing MS. (This is known as clinically isolated syndrome or CIS.)

Treatment should be continued indefinitely except in the case of clear lack of benefit, intolerable side effects, new data, or if a better treatment becomes available.

Individuals should be allowed to change therapies.

Treatment should not be interrupted for insurance purposes.

None of these medications are approved for use in women who are pregnant, nursing, or may become pregnant.

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Learn About Multiple Sclerosis - Treatments for Multiple ...