Multiple Sclerosis and Stem Cell Therapy

Review of the novelties presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (III).

Rev Neurol. 2013 Oct 1;57(7):317-29

Authors: Fernndez , Arnal-Garca C, Arroyo-Gonzlez R, Brieva L, Calles-Hernndez MC, Casanova-Estruch B, Comabella M, de las Heras V, Garca-Merino JA, Hernndez-Prez MA, Izquierdo G, Matas E, Meca-Lallana JE, Mendibe-Bilbao Mdel M, Muoz-Garca D, Olascoaga J, Oreja-Guevara C, Prieto JM, Rami-Torrent L, Rodrguez-Antigedad A, Saiz A, Tllez N, Villar LM, Tintor M, Post-ECTRIMS Group

Abstract The most significant data presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in France in October 2012, have been summarised in the fifth edition of the Post-ECTRIMS Experts Meeting, held in Madrid in October 2012. This led to the drafting of this review, which has been published in three parts. This third part of the Post-ECTRIMS review presents the findings from the latest studies conducted with disease-modifying treatments, more specifically with glatiramer acetate, laquinimod, ponesimod, BG-12, teriflunomide, daclizumab, natalizumab and secukinumab (AIN457). Likewise, we also address the reasons that justify the search for innovative treatments for multiple sclerosis, with antigen-specific therapy, cell therapy and therapy aimed at promoting remyelination being highlighted among other future therapeutic strategies. Access to new pharmacological agents and the complexity of the therapy of multiple sclerosis in the future will require new design strategies and directions in clinical trials, including the use of surrogate markers, new statistical applications, superiority, inferiority or equivalence clinical trials and adaptable designs.

PMID: 24052443 [PubMed - indexed for MEDLINE]

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Multiple Sclerosis and Stem Cell Therapy