'Unprecedented': Drug May Help Heal Damaged Spines

Researchers say they've developed a drug that may help heal a damaged spine the first time anything like a drug has been shown to help.

The drug works on nerve cells that are cut, sending connections across the break, and it helped injured rats move their back legs again and also gave them back control of their bladders.

"This recovery is unprecedented," said Jerry Silver, a neuroscience professor at Case Western Reserve University in Ohio who led the study.

Right now, there's no good way to heal a broken spine. Sometimes people grow nerve cells back, but usually not. All the cures that are in the works require invasive surgery, whether it's injections of stem cells, nerve tissue transplants or implants of neurostimulators.

But Silver's team came up with a compound that is injected. It doesn't require surgery.

"We're very excited at the possibility that millions of people could, one day, regain movements lost during spinal cord injuries."

"There are currently no drug therapies available that improve the very limited natural recovery from spinal cord injuries that patients experience," said Lyn Jakeman, a program director at the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, which helped pay for the study. "This is a great step toward identifying a novel agent for helping people recover."

"We're very excited at the possibility that millions of people could, one day, regain movements lost during spinal cord injuries," Silver added.

One of the problems with repairing a crushed spine is scar tissue. The body grows a lot of it, and even if nerve cells try to send out little growths called axons across the breach, they get bogged down by the scar tissue.

The culprits are molecules called proteoglycans. They are covered with sugars, and like anything sugary, they are sticky and grab the delicate axons that nerve cells grow to connect to other nerves. "What we found is that when nerve fibers are damaged they have a receptor that can see those proteoglycan molecules and stick tightly to it. They stick so tightly they can't move. It's like flypaper," Silver told NBC News.

Link:
'Unprecedented': Drug May Help Heal Damaged Spines