Pronunciation: ris-PER-i-done Class: Benzisoxazole antipsychotic
Risperdal - Tablets, oral 0.25 mg - Tablets, oral 0.5 mg - Tablets, oral 1 mg - Tablets, oral 2 mg - Tablets, oral 3 mg - Tablets, oral 4 mg - Solution, oral 1 mg/mL
Risperdal Consta - Injection, powder for suspension, ER 12.5 mg - Injection, powder for suspension, ER 25 mg - Injection, powder for suspension, ER 37.5 mg - Injection, powder for suspension, ER 50 mg
Risperdal M-TAB - Tablets, orally disintegrating 0.5 mg - Tablets, orally disintegrating 1 mg - Tablets, orally disintegrating 2 mg - Tablets, orally disintegrating 3 mg - Tablets, orally disintegrating 4 mg
Risperidone - Tablets, orally disintegrating 0.25 mg
Has antipsychotic effect, apparently caused by dopamine- and serotonin-receptor blocking in CNS.
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Absolute oral bioavailability is 70%. T max is 1 h (risperidone), 3 h (9-hydroxyrisperidone extensive metabolizers), or 17 h (9-hydroxyrisperidone poor metabolizers). Steady state is approximately 1 day (extensive metabolizers) or approximately 5 days (poor metabolizers).
The main release of the drug starts 3 wk after injection, is maintained from 4 to 6 wk, and subsides by 7 wk. Steady state is reached after 4 injections.
Rapidly distributed. Vd is 1 to 2 L/kg. Protein binding is approximately 90% (parent compound) or approximately 77% (9-hydroxyrisperidone).
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