PUBLIC RELEASE DATE:
7-Dec-2013
Contact: Kassidie Blackstock Kassidie.Blackstock@fleishman.com 865-776-6827 American Society of Hematology
(NEW ORLEANS, December 7, 2013) Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies. Several studies representing these advances were presented today during the 55th American Society of Hematology Annual Meeting and Exposition in New Orleans.
HSCT is effectively used today as a form of "replacement" therapy for patients with hard-to-treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own. Historically, clinicians evaluating a patient for transplant have sought to identify donor cells that are perfectly matched to the patient's cell type, which is considered to be the optimal approach to help ensure successful outcomes and to minimize risk of graft-versus-host disease (GVHD), a serious and potentially life-threatening complication that occurs when the donated immune cells attack the patient's cells as foreign tissue.
Today, researchers are challenging traditional assumptions about transplant eligibility and donor matching in an effort to expand the universe of patients who can benefit from this treatment while improving long-term success rates. New findings presented today indicate that with proper considerations, haploidentical (half-matched) transplants or transplants using cord blood cells can be viable, effective alternatives when a fully matched donor is not available. Researchers also contend that transplant outcomes can be further improved by identifying patients who are at high risk for certain complications, such as cognitive decline, or by employing post-transplant treatments to reduce their risk of relapse.
"The exciting research results being presented today underscore how transplants are becoming an increasingly successful treatment option for more patients with blood cancer than ever before," said Jeffrey Miller, MD, moderator of the press conference and Deputy Director of the Masonic Cancer Center and the Clinical and Translational Sciences Institute at the University of Minnesota in Minneapolis. "Whereas transplant would not have been an option for many patients without a sibling or other perfectly matched donor even several years ago, exciting new strategies have afforded them the opportunity to gain significant benefit from this procedure today. As we are now able to focus our efforts on improving the overall patient experience and reducing the risk of relapse, the leading cause of death after transplant, we have greatly improved long-term survival outcomes for patients who before might not have had another treatment option."
This press conference will take place on Saturday, December 7, 2013, at 10:00 a.m. CST.
Encouraging Outcomes in Older Patients (Pts) Following Nonmyeloablative (NMA) Haploidentical Blood or Marrow Transplantation (haploBMT) With High-Dose Posttransplantation Cyclophosphamide (PT/Cy) [158]
To more fully demonstrate the utility of haploidentical bone marrow or peripheral blood stem cell transplants (haploBMT) as an alternative to fully matched transplants, this study evaluated nonmyeloablative, related haploBMT (with post-transplantation cyclophosphamide) among patients aged 50 75 with poor-risk hematologic malignancies. Results of 273 such transplants performed at Johns Hopkins were compared to determine the impact of older age on outcomes. The two-year probability of progression-free survival was very similar among patients in their 50s, 60s, and 70s (39, 36, and 39%, respectively), as was the two-year probability of overall survival (51, 56, and 44%). Among these age groups, there were also no statistically significant differences in the risks of non-relapse death or severe graft-versus-host disease.
Go here to see the original:
Advances in stem cell transplantation strategies show promise to improve availability, success
- Bone Marrow Transplant Stem Cell Transplant patient shares her experience at International Oncology - Video [Last Updated On: March 29th, 2013] [Originally Added On: March 29th, 2013]
- Ellen's journey through lymphoma and a stem cell transplant. - Video [Last Updated On: April 23rd, 2013] [Originally Added On: April 23rd, 2013]
- Stem Cell Transplant Hangout - Video [Last Updated On: May 3rd, 2013] [Originally Added On: May 3rd, 2013]
- Interview with Sarah Kelm of the Immunotherapy [Last Updated On: May 13th, 2013] [Originally Added On: May 13th, 2013]
- 'Off-the-shelf' virus-specific T-cells fight viral infections in stem cell transplant patients [Last Updated On: May 15th, 2013] [Originally Added On: May 15th, 2013]
- Dr. Patrick Stiff Named Chair of SWOG Bone Marrow and Stem Cell Transplantation Committee [Last Updated On: May 18th, 2013] [Originally Added On: May 18th, 2013]
- 2013 Blume-Schmidt Memorial Lecture - Stem cell transplant experts gather to honor pioneer - Video [Last Updated On: May 27th, 2013] [Originally Added On: May 27th, 2013]
- Study Shows Significantly Improved Survival Rates for Stem Cell Transplant Recipients [Last Updated On: May 29th, 2013] [Originally Added On: May 29th, 2013]
- Roy Jones [Last Updated On: June 8th, 2013] [Originally Added On: June 8th, 2013]
- Study sets guidelines for stem cell transplants in older patients with myelodysplastic syndromes [Last Updated On: June 25th, 2013] [Originally Added On: June 25th, 2013]
- Karmanos Cancer Center Blood and Marrow Stem Cell Transplant Program Gets Foundadtion Accreditation [Last Updated On: June 25th, 2013] [Originally Added On: June 25th, 2013]
- Bone marrow stem cell transplant reduces insulin usage in type 2 diabetes patients [Last Updated On: June 29th, 2013] [Originally Added On: June 29th, 2013]
- View From My Stem Cell Transplant Ward - Video [Last Updated On: June 29th, 2013] [Originally Added On: June 29th, 2013]
- Stem Cell Transplant 2010 - Video [Last Updated On: June 29th, 2013] [Originally Added On: June 29th, 2013]
- Cml stem cell transplant Day (-6) - Video [Last Updated On: July 1st, 2013] [Originally Added On: July 1st, 2013]
- Stem Cell Transplant and Cellular Therapy Unit at CTCA in Philadelphia - Video [Last Updated On: July 1st, 2013] [Originally Added On: July 1st, 2013]
- CML Stem Cell Transplant Day (-5) - Video [Last Updated On: July 4th, 2013] [Originally Added On: July 4th, 2013]
- Ethan Zohn: What my stem cell transplant was like - Video [Last Updated On: July 6th, 2013] [Originally Added On: July 6th, 2013]
- Last of My Autologous Stem Cell Transplant - Video [Last Updated On: July 7th, 2013] [Originally Added On: July 7th, 2013]
- Cml stem cell transplant day (-1) - Video [Last Updated On: July 7th, 2013] [Originally Added On: July 7th, 2013]
- Stem Cell Transplant Survivors Meet by Dr. Chirag Shah Part 3 - Video [Last Updated On: July 11th, 2013] [Originally Added On: July 11th, 2013]
- Stem Cell Transplant Survivors Meet by Dr. Chirag Shah Part 2 - Video [Last Updated On: July 11th, 2013] [Originally Added On: July 11th, 2013]
- Stem Cell Transplant Survivors Meet by Dr. Chirag Shah Part 1 - Video [Last Updated On: July 11th, 2013] [Originally Added On: July 11th, 2013]
- Argentine boy heads home after stem cell transplant at Duke [Last Updated On: July 12th, 2013] [Originally Added On: July 12th, 2013]
- Helping Julia in her fight for a stem cell transplant - Video [Last Updated On: July 28th, 2013] [Originally Added On: July 28th, 2013]
- Stem cell transplant will give Katy teen a new lease on life [Last Updated On: August 1st, 2013] [Originally Added On: August 1st, 2013]
- Scientists identify biomarker to predict immune response risk after stem cell transplants [Last Updated On: August 7th, 2013] [Originally Added On: August 7th, 2013]
- Andrew Madoff Battling Stage-Four Cancer, Receives Donor Infusion After Stem Cell Transplant [Last Updated On: August 10th, 2013] [Originally Added On: August 10th, 2013]
- CML Stem cell transplant day (-2) - Video [Last Updated On: August 10th, 2013] [Originally Added On: August 10th, 2013]
- CML Stem cell transplant day +34 - Video [Last Updated On: August 10th, 2013] [Originally Added On: August 10th, 2013]
- India stem cell transplant - Video [Last Updated On: August 11th, 2013] [Originally Added On: August 11th, 2013]
- Local Stem Cell Transplant Program Keeping More Patients Closer to Home (KDFA-TV, Amarillo) - Video [Last Updated On: August 12th, 2013] [Originally Added On: August 12th, 2013]
- How to Say or Pronounce Stem Cell Transplant - Video [Last Updated On: August 21st, 2013] [Originally Added On: August 21st, 2013]
- Girl, 10, shows no sign of sickle cell after stem cell transplant in St. Louis [Last Updated On: September 1st, 2013] [Originally Added On: September 1st, 2013]
- Three months after risky stem cell transplant, young patient shows no signs of sickle cell [Last Updated On: September 1st, 2013] [Originally Added On: September 1st, 2013]
- Neil Mitchell chats to Mauro about his Stem Cell Transplant - Alfred Hospital - Video [Last Updated On: September 2nd, 2013] [Originally Added On: September 2nd, 2013]
- Lorelei Decker shares good news following stem cell transplant [Last Updated On: September 25th, 2013] [Originally Added On: September 25th, 2013]
- Adult Stem Cell Transplant Saves Tony Underhill from Scleroderma - Video [Last Updated On: September 30th, 2013] [Originally Added On: September 30th, 2013]
- Peter's Stem cell transplant Journey - Video [Last Updated On: October 7th, 2013] [Originally Added On: October 7th, 2013]
- Presque Isle infant needs stem cell transplant to beat life-threatening illness [Last Updated On: October 13th, 2013] [Originally Added On: October 13th, 2013]
- Stem cell transplant repairs damaged gut in mouse model of inflammatory bowel disease [Last Updated On: October 18th, 2013] [Originally Added On: October 18th, 2013]
- Study evaluates early stem cell transplants for non-Hodgkin's lymphoma [Last Updated On: October 31st, 2013] [Originally Added On: October 31st, 2013]
- Hematopoietic stem cell transplantation - Wikipedia, the free ... [Last Updated On: November 3rd, 2013] [Originally Added On: November 3rd, 2013]
- Stem cell transplants : Cancer Research UK : CancerHelp UK [Last Updated On: November 3rd, 2013] [Originally Added On: November 3rd, 2013]
- Bone Marrow Transplant and Stem Cell Transplant Program, Siteman ... [Last Updated On: November 3rd, 2013] [Originally Added On: November 3rd, 2013]
- Stem cell transplants for non Hodgkin lymphoma : Cancer Research ... [Last Updated On: November 3rd, 2013] [Originally Added On: November 3rd, 2013]
- Katherine's stem cell transplant - Video [Last Updated On: November 3rd, 2013] [Originally Added On: November 3rd, 2013]
- Stem Cell Transplant - Dana-Farber Cancer Institute [Last Updated On: November 11th, 2013] [Originally Added On: November 11th, 2013]
- Peripheral Blood Stem Cell Transplant Donor, Procedure, Benefits ... [Last Updated On: November 11th, 2013] [Originally Added On: November 11th, 2013]
- A Journey Through A Stem Cell Transplant - Diane M. Sullivan - Video [Last Updated On: November 11th, 2013] [Originally Added On: November 11th, 2013]
- Bone Marrow - Dr B S Rajput Stem Cell Transplant Surgeon - Video [Last Updated On: November 16th, 2013] [Originally Added On: November 16th, 2013]
- Stem Cell Transplant Blog [Last Updated On: November 18th, 2013] [Originally Added On: November 18th, 2013]
- LHC Better Living: Stem Cell Transplant - Video [Last Updated On: November 18th, 2013] [Originally Added On: November 18th, 2013]
- India stem cell transplant by Dr B S Rajput stem cell transplant Surgeon - Video [Last Updated On: November 21st, 2013] [Originally Added On: November 21st, 2013]
- Stem Cell Transplants For Incurable and Untreatable Diseases ... [Last Updated On: November 23rd, 2013] [Originally Added On: November 23rd, 2013]
- Type of Treatment - Stem Cell Transplantation | MD Anderson ... [Last Updated On: November 23rd, 2013] [Originally Added On: November 23rd, 2013]
- Stem Cell Transplantations: Cancer Treatment | MD Anderson ... [Last Updated On: November 24th, 2013] [Originally Added On: November 24th, 2013]
- Datri 1st successful unrelated Blood Stem Cell Transplant - Video [Last Updated On: November 24th, 2013] [Originally Added On: November 24th, 2013]
- India stem cell transplant bone marrow by Dr. B. S. Rajput stem cell transplant surgeon - Video [Last Updated On: November 26th, 2013] [Originally Added On: November 26th, 2013]
- Stem Cell Transplants - Nemours: Kids Health [Last Updated On: November 27th, 2013] [Originally Added On: November 27th, 2013]
- Stem Cell Transplantation for Cancer Treatment | CTCA [Last Updated On: November 29th, 2013] [Originally Added On: November 29th, 2013]
- Bone Marrow/Stem Cell Transplant - Video [Last Updated On: November 29th, 2013] [Originally Added On: November 29th, 2013]
- Treatment Options - Stem Cell Transplantation [Last Updated On: December 3rd, 2013] [Originally Added On: December 3rd, 2013]
- Stem cell transplant: All - MayoClinic.com [Last Updated On: December 4th, 2013] [Originally Added On: December 4th, 2013]
- The Phases Of Stem Cell Transplant Treatment - Video [Last Updated On: December 5th, 2013] [Originally Added On: December 5th, 2013]
- Recurrent follicular lymphoma: Novel approaches vs stem cell transplant - Video [Last Updated On: December 5th, 2013] [Originally Added On: December 5th, 2013]
- Breakthrough in Treating Leukemia, Lymphoma Patients with Umbilical Cord Blood Stem Cells [Last Updated On: December 12th, 2013] [Originally Added On: December 12th, 2013]
- Wilson undergoes transplant on Thursday [Last Updated On: December 12th, 2013] [Originally Added On: December 12th, 2013]
- Breakthrough in treating leukemia, lymphoma with umbilical cord blood stem cells [Last Updated On: December 12th, 2013] [Originally Added On: December 12th, 2013]
- HIV Returns in Two Men Thought Cured After Stem Cell Transplant [Last Updated On: December 12th, 2013] [Originally Added On: December 12th, 2013]
- Wilson resting following stem cell transplant [Last Updated On: December 13th, 2013] [Originally Added On: December 13th, 2013]
- Boyd: 'I am cancer-free' [Last Updated On: December 15th, 2013] [Originally Added On: December 15th, 2013]
- Bone Marrow Harvest for Stem Cell Transplant - Video [Last Updated On: December 16th, 2013] [Originally Added On: December 16th, 2013]
- Bone Marrow Stem Cell Transplant - Video [Last Updated On: December 16th, 2013] [Originally Added On: December 16th, 2013]
- Amyloidosis - Ongoing Research and Collaboration - Video [Last Updated On: December 16th, 2013] [Originally Added On: December 16th, 2013]
- Ruxolitinib before Stem Cell Transplant - Video [Last Updated On: December 16th, 2013] [Originally Added On: December 16th, 2013]
- The Multi Disciplinary Team Involved In A Stem Cell Transplant - Video [Last Updated On: December 16th, 2013] [Originally Added On: December 16th, 2013]
- Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation [Last Updated On: December 19th, 2013] [Originally Added On: December 19th, 2013]
- Why Amyloidosis: Two Doctors Discuss Their Paths To The Disease - Video [Last Updated On: December 19th, 2013] [Originally Added On: December 19th, 2013]
- Debbie Stokes' stem cell transplant day video - Video [Last Updated On: December 19th, 2013] [Originally Added On: December 19th, 2013]