Amniotic stem cells show promise in helping to repair cardiac birth defects

Public release date: 9-Oct-2013 [ | E-mail | Share ]

Contact: Sally Garneski pressinquiry@facs.org 312-202-5409 American College of Surgeons

WASHINGTON, DCResearchers at the University of Michigan Department of Surgery have begun testing an alternative to embryonic stem cells that could one day regenerate muscle tissue for babies with congenital heart defects. A research-in-progress report on this new approach, which uses amniotic stem cells, was presented today at the 2013 Clinical Congress of the American College of Surgeons. Although this research is still in an early phase, this new approach has the potential to one day help thousands of babies born each year with congenital heart defects.

Typically, a pregnant woman can have a fetal ultrasound performed to find out the sex of her baby between 18 and 20 weeks gestation. But each year during pregnancy or after birth, 40,000 women also find out that their babies have birth defects in their hearts, according to the Centers for Disease Control and Prevention.*

Babies with congenital heart defects often go through multiple heart operations or even a transplant before their first birthday. But Shaun Kunisaki, MD, a pediatric surgeon and assistant professor of surgery at the University of Michigan, and his surgical team are testing a new method of regenerating defective heart tissue so that one day these multiple operations may no longer be necessary.

"We know that the baby's heart cells are functioning, but the muscle has developed abnormally," lead study author Dr. Kunisaki said. "We have to find the right source of new cells to replace the damaged cells or generate new tissue to augment the damaged heart."

Stem Cell Shortfalls

Until now embryonic stem cells have shown potential to morph into various types of organ tissues, but the ethics surrounding the process of having to destroy the embryo to achieve this outcome has drawn controversy.

Stem cells from bone marrow have also seemed promising, but such cells are obviously hard to obtain from a fetus. Furthermore, getting bone marrow from a donor brings about the same risk as having a heart transplanthaving to suppress the newborn infant's immune system so that its body doesn't reject the foreign cells. "Also, bone marrow cells are not made to function like heart muscle cells, but rather to protect against inflammation," Dr. Kunisaki explained.

Cardiac stem cells, which are in the heart, have also been considered, but the heart contains a very limited number of these stem cells.

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Amniotic stem cells show promise in helping to repair cardiac birth defects