November 16, 2014
Rayshell Clapper for redOrbit.com Your Universe Online
Every day, across the United States, some little kid loses a tooth, which means every night that same little kid has a magical visit from the tooth fairy who replaces it with money. But what happens to those teeth? Sure, they may be stored away as keepsakes, but thats a lot of baby teeth for parents to pack away.
Scientifically, there are some serious benefits in studying those teeth. In fact, the Radiation and Public Health Project started a program called the Tooth Fairy Project. This project has participating families send the baby teeth in so that they can study them, specifically looking at elements the teeth have been exposed to since inception. The program looks for Radioactive Strontium-90 (Sr-90) because it is so deadly, and like calcium the body stores it in the bones and teeth indefinitely. Sr-90 will continue to emit cancer-causing radiation, so studying baby teeth will help researchers accurately determine when and where radioactivity was absorbed from the environment.
But this is not the only study for which the Tooth Fairy Project has proven to be a benefit. According to the University of California San Diego (UCSD), the Tooth Fairy Project has recently benefited studies on autism. The teeth also go to other researchers, and these scientists extract dental pulp cells from the tooth and differentiate them into iPSC-derived neurons.
iPSC or induced pluripotent stem cells have implicated a new gene on the autism spectrum disorder (ASD) that falls under the idiopathic category. Idiopathic means non-syndromic autism or autism in which the cause is unknown as defined by the National Human Genome Research Institute. About 85 percent of those who have been diagnosed with autism have idiopathic autism.
The gene discovered by UCSD scientists lead by Alysson Muotri, PhD, associate professor in the UCSD departments of Pediatrics and Cellular and Molecular Medicine, shows an association to Rett syndrome, one of the ASDs, but also supports the idea that different types of ASDs could likely share similar molecular pathways.
As UCSDs Scott LaFee explains, The latest findings, in fact, are the result of Muotris first tooth fairy donor. He and colleagues identified a de novo or new disruption in one of the two copies of the TRPC6 gene in iPSC-derived neurons of a non-syndromic autistic child. They confirmed with mouse models that mutations in TRPC6 resulted in altered neuronal development, morphology and function. They also noted that the damaging effects of reduced TRPC6 could be rectified with a treatment of hyperforin, a TRPC6-specific agonist that acts by stimulating the functional TRPC6 in neurons, suggesting a potential drug therapy for some ASD patients.
Image Caption: This is Alysson Muotri, Ph.D. Credit: UC San Diego School of Medicine
Excerpt from:
Autism Researchers Get A Little Help From The Tooth Fairy