Category Archives: Brain Injury Treatment

Dementia is an umbrella term encompassing many differing conditions that affect the structure and function of the brain. These conditions can lead to problems with memory, orientation, word-finding and problem-solving. Vascular dementia is the second most common form of dementia diagnosed in those over the age of 65, with 150,000 people in the UK living with this condition (NHS) Continue reading →

Feb 11, 2021 3:30 PM A seizure is a medical condition that causes abnormal activity and/or body movements after a sudden and uncontrolled disturbance in your brain. Continue reading →

Introduction Neonatal hypoxia-ischemia (HI) brain injury is associated with mortality or severe neurological disabilities.1 Accordingly, understanding of the pathologic and survival mechanisms of HI injury on brain functions represents a critical area of investigation for the development of neuroprotective treatments. Hydrogen sulfide (H2S) has been reported to be involved in modulating physiological and pathological processes within the central nervous systems.2,3 Normally, in mammalian cells, H2S originates from the metabolism of L-Cysteine through catalysis involving three enzymes, cystathionine--synthase (CBS), cystathionine--lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). These H2S-producing enzymes are highly expressed in various types of tissue and cells, including the brain.4 An exogenous administration of H2S has been shown to exert a neuroprotective effect through its capacity to affect anti-apoptotic, anti-inflammatory and anti-oxidative functions.5,6 Recently, we reported that L-Cysteine was able to suppress HI-induced microglial activation and neuroinflammation by releasing H2S.7,8 Although these reports indicate neuroprotective effects of H2S, the underlying mechanisms of this neuroprotection against brain damage resulting from HI have not been fully elucidated Continue reading →

Introduction Intracerebral hemorrhage (ICH) is a severe form of stroke, accounting for 10% of the stroke patients.1 ICH is a common cerebrovascular disorder with high mortality, which has become a heavy burden for families and countries.2 ICH refers to the extravasation of blood caused by the rupture of blood vessels within the brain parenchyma, resulting in neuronal death.3 In the last years, the morbidity of ICH is increasing, however, it is still devoid of effective treatment.4 Evidences during the past decades prove that the pathological process of ICH includes the primary brain damage resulting from mass effect owing to hematoma formation, and the secondary brain injury triggered by the extension of hematoma into the ventricles.5 Hence, a depth understanding of the mechanism underlying ICH-induced secondary brain damage has considerable significance that will help to develop efficient therapeutic strategies for ICH. Hemin is a breakdown product of hemoglobin and is the main cause of neuronal death during ICH.6 Following ICH, hemolysis of erythrocytes leads to hematoma resolution and the release of hemoglobin into the brain tissues.7 Subsequently, hemin liberated from hemoglobin may intercalate into cell membranes directly or enter brain cells via the heme carrier protein 1/proton-coupled folate transporter.8 When hemin internalizes to brain cells, hemin can trigger DNA fragmentation, oxidative stress and inflammatory response, resulting in cell death.9 Besides, hemin is catabolized by heme oxygenases into biliverdin, CO, and iron, which in turn causes lipid peroxidation.10 Increasing evidence suggests that hemin-induced apoptosis and inflammation have emerged as vital contributors to ICH-induced brain damage.11 Nevertheless, the mechanism of hemin-induced apoptosis and inflammation remains elusive. Understanding the mechanism underlying hemin-induced apoptosis and inflammation, therefore, is of significance for ICH therapy Continue reading →

Westbound traffic stopped at Downtown Tunnel due to crash involving tractor-trailer Bipartisan teen driving safety bill passes Virginia General Assembly unanimously US Sen. Warner leaves checkup of Hampton VA hospital with upbeat report on COVID-19 vaccinations, wait times Virginias COVID-19 vaccine registration site goes online, experiences some issues Black History Month: Local NBA referee scores big with philanthropy and fine dining Congressional dysfunction has compromised Navy funding, training, local congressman says Chesapeake Regional healthcare partnering with 20 African American churches to provide COVID-19 vaccines From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League Dominion Energy gives $50,000 boost to mental health clinic for military families, children WAVY News 10 at 6:00 pm US lawmakers weigh options to guarantee election security in the future WAVY's Andy Fox walks you through Virginia's new statewide COVID-19 vaccine registration system North Carolina tornado news conference Latest Bipartisan teen driving safety bill passes Virginia General Assembly unanimously News / 3 hours ago US Sen. Warner leaves checkup of Hampton VA hospital with upbeat report on COVID-19 vaccinations, wait times News / 3 hours ago Virginias COVID-19 vaccine registration site goes online, experiences some issues News / 3 hours ago Black History Month: Local NBA referee scores big with philanthropy and fine dining News / 3 hours ago Congressional dysfunction has compromised Navy funding, training, local congressman says News / 3 hours ago Chesapeake Regional healthcare partnering with 20 African American churches to provide COVID-19 vaccines News / 3 hours ago From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League News / 3 hours ago Dominion Energy gives $50,000 boost to mental health clinic for military families, children News / 3 hours ago WAVY News 10 at 6:00 pm News / 3 hours ago US lawmakers weigh options to guarantee election security in the future News / 5 hours ago WAVY's Andy Fox walks you through Virginia's new statewide COVID-19 vaccine registration system News / 5 hours ago North Carolina tornado news conference News / 8 hours ago Local News From imagination to reality: Norfolk Collegiate middle schoolers competing at state level of FIRST LEGO League News / 3 hours ago Dominion Energy gives $50,000 boost to mental health clinic for military families, children News / 3 hours ago WAVY News 10 at 6:00 pm News / 3 hours ago Black History Month: Local NBA referee scores big with philanthropy and fine dining News / 3 hours ago Sen. Continue reading →

According to some estimates, chronic pain affects up to 40% of Americans, and treating it frustrates both clinicians and patientsa frustration thats often compounded by a hesitation to prescribe opioids for pain. Continue reading →

Chesapeake stores are the first Rite Aid locations in Virginia to start giving out COVID-19 vaccines Bipartisan teen driving safety bill passes Virginia General Assembly unanimously US Sen. Continue reading →

Worldwide Coma Diagnosis and Treatment Market Analysis to 2027 is a specialized and in-depth study of the Coma Diagnosis and Treatment Market Industry with a focus on the global market trend. The report aims to provide an overview of global Coma Diagnosis and Treatment Market with detailed market segmentation by product/application and geography. The global Coma Diagnosis and Treatment Market is expected to witness high growth during the forecast period. Continue reading →

By Deborah Borfitz January 27, 2021 | An intracellular signaling network known as the integrated stress response (ISR) is of growing interest to drug developers because it seems to be affecting so many clinical conditions, ranging from Down syndrome and traumatic brain injury (TBI) to hearing loss, some types of prostate cancer, and the natural process of aging, according to Susanna Rosi, Ph.D., director of neurocognitive research in the UCSF Brain and Spinal Injury Center. The original study in PNAS (DOI: 10.1073/pnas.1707661114) showing that ISR inhibition reverses cognitive deficits after TBI was conducted in the Rosi lab at the University of California, San Francisco, where she is a professor in the departments of neurological surgery and physical therapy and rehabilitation science. The next logical step was to see if the same approach could undo age-related cognitive decline, which indeed it could and in a matter of daysat least in mice Continue reading →

Two-time Stanley Cup winner Daniel Carcillo is the co-founder and CEO of Wesana Health, a company ... [+] that recently raised $4 million to fund clinical trials and drug development focusing on traumatic brain injury and psilocybin Continue reading →