Category Archives: Cell Medicine

ScienceDaily (Feb. 2, 2012) — Cell biologists at Johns Hopkins have identified key steps in how certain molecules alter a cell's skeletal shape and drive the cell's movement. Results of their research, published in the December 13 issue of Science Signaling, have implications for figuring out what triggers the metastatic spread of cancer cells and wound-healing. "Essentially we are figuring out how cells crawl," says Takanari Inoue, Ph.D., an assistant professor of cell biology and member of the Center for Cell Dynamics in the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "With work like ours, scientists can reveal what happens when cells move when they aren't supposed to." Their new discovery highlights the role of the cell's skeleton, or cytoskeleton, in situations where "shape shifting" can rapidly change a cell's motion and function in response to differing environmental conditions. When cell's such as fibroblasts, which gather to heal wounds, move from one place to another, its cytoskeleton forms ripple-like waves or ruffles across its surface that move towards the front of the cell and down, helping pull the cell across a surface. Researchers have shown that these ruffles form when a small molecule, PIP2, appears on … Continue reading →

ScienceDaily (Feb. 2, 2012) — Cell biologists at Johns Hopkins have identified key steps in how certain molecules alter a cell's skeletal shape and drive the cell's movement. Results of their research, published in the December 13 issue of Science Signaling, have implications for figuring out what triggers the metastatic spread of cancer cells and wound-healing. "Essentially we are figuring out how cells crawl," says Takanari Inoue, Ph.D., an assistant professor of cell biology and member of the Center for Cell Dynamics in the Johns Hopkins University School of Medicine's Institute for Basic Biomedical Sciences. "With work like ours, scientists can reveal what happens when cells move when they aren't supposed to." Their new discovery highlights the role of the cell's skeleton, or cytoskeleton, in situations where "shape shifting" can rapidly change a cell's motion and function in response to differing environmental conditions. When cell's such as fibroblasts, which gather to heal wounds, move from one place to another, its cytoskeleton forms ripple-like waves or ruffles across its surface that move towards the front of the cell and down, helping pull the cell across a surface. Researchers have shown that these ruffles form when a small molecule, PIP2, appears on … Continue reading →

TORONTO, Feb. 2, 2012 /CNW/ - Dr. Tom Hudson, President and Scientific Director of The Ontario Institute for Cancer Research (OICR), today announced a new study to develop a framework for the implementation of personalized medicine in cancer care. The framework aims to integrate genomics research into everyday clinical practice, with a goal to provide improved and more targeted care for patients. Published in the journal Cell, the framework supports improved diagnostics for cancer patients based on DNA analyses of tumours. The results of these analyses could be used to predict a patient's response to novel therapies. More immediately, it could be used to predict how drugs currently approved and in use today could help to treat other types of cancer. "As the cost of genome sequencing decreases, we are presented with the reality that soon genome analysis will be no more or less expensive than most diagnostic tests in use today," said Dr. Hudson. "This presents a huge opportunity to improve diagnosis for patients and ultimately improve patient outcomes. But in order to implement these tools, we must first understand their impact in a clinical setting." "This framework is not about simply doing a new test but creating evidence … Continue reading →

01-02-2012 14:17 Visit our Website: http://www.triconference.com The rapid expansion in the use of circulating tumor cells (CTCs) as a diagnostic tool and a biomarker will provide a much needed tool in the treatment of cancer. The use of CTCs provides a non-invasive means of gaining early insight into tumor detection and metastasis, and has become an indispensable tool for patient management and oncology drug development. This conference dedicated to CTCs will cover a range of aspects concerning CTCs' origin, biology, characterization, enumeration and subsequent analysis. The conference will also highlight approaches to technology development that include the use of microfluidics for cell enumeration, and case studies on the clinical use of CTCs for guiding the selection of therapy and monitoring response. This meeting will bring you up to date on the state-of-the-art tools and what is needed to make these technologies robust and ready for use by the clinical community. Continue reading here: Circulating Tumor Cells - Expediting Clinical Use - Molecular Medicine Tri-Conference - Video … Continue reading →

01-02-2012 14:59 Sridhar Ramaswamy, MD, Massachusetts General Hospital Cancer Center, Assistant Professor of Medicine, Harvard Medical School, Harvard Stem Cell Institute, discusses targeting dormant cancer cells and the possible role that they play in the development of drug resistance. Dormant cells appear in most patients with tumors. These cells are not rapidly proliferating and remain largely inactive. While these cells sleep, they are highly resistant to most types of therapy. Dormant cancer cells are intrinsically intriguing because the number of inherent mutations would denote that the cells should be rapidly proliferating. The mechanism that allows them to switch between dormant and active is yet unknown. The goal of the research is to discover the underlying cause of the dormancy, tumor progression, and the mechanism of resistance to various types of therapy. Here is the original post: Dr. Ramaswamy on Targeting Dormant Cancer Cells - Video … Continue reading →

01-02-2012 15:01 Submitted for a competition for the Greatest Chemical Discovery in the Past 100 Years, this video explains the mechanism, chemistry, history and more about Penicillin. Read more: Penicillin: The Greatest Chemical Discovery in the Past 100 Years - Video … Continue reading →

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31-10-2011 06:02 Get the facts on Metabolic Syndrome with this 100%-accurate animated video. Part of Focus Apps' Understanding Disease: Diabetes and Endocrinology series, the Metabolic Syndrome app describes the condition and explores how multiple risk factor intervention using combinations of therapeutic agents for diabetes also targets underlying insulin resistance. Learn more about causes, risk factors, treatment, and self-care options. http://www.focusappsstore.net More here: Functions of Insulin - Video … Continue reading →

24-01-2012 18:39 Four minute excerpt from the Spotlight on Genomics seminar presentation during the January 17th 2012 California Institute for Regnerative Medicine governing board meeting. The video features a conversation between Catriona Jamieson, director for stem cell research at UCSD Moores Cancer Center, and one of her patients who is participating in a clinical trial for the treatment of myelofibrosis, a life-threatening blood disorder. Read this article: Clinical Trial for Myelofibrosis that Targets Cancer Stem Cells | CIRM Spotlight on Genomics - Video … Continue reading →

24-01-2012 18:39 Four minute excerpt from the Spotlight on Genomics seminar presentation during the January 17th 2012 California Institute for Regnerative Medicine governing board meeting. The video features a conversation between Catriona Jamieson, director for stem cell research at UCSD Moores Cancer Center, and one of her patients who is participating in a clinical trial for the treatment of myelofibrosis, a life-threatening blood disorder. Read this article: Clinical Trial for Myelofibrosis that Targets Cancer Stem Cells | CIRM Spotlight on Genomics - Video … Continue reading →