Category Archives: Cell Therapy

1102 Bates Street, Suite 1670 Houston, Texas 77030 The GMP Facilities at the Center for Cell and Gene Therapy at Baylor College of Medicine are among the largest and most modern in the United States. Manufacturing of therapeutic biologics has existed at Baylor for more than twenty years, and is now centralized in 19,000 square feet on the 16th floor of the Feigin Center at Texas Childrens Hospital. This facility opened in 2010 and contains 22 ISO 7 clean room suites supported by dedicated space for cell and product cold storage, flow cytometric analysis, quality control testing, data management and storage and quality assurance activities. The staff has extensive experience in GMP manufacturing of a wide variety of products and intermediates for cellular therapies and of viral and non-viral vectors, and master and working cell banks. Manufacturing and testing supports more than 30 investigator-sponsored INDs conducted at the Texas Medical Center and institutions around the United States. Products have also been prepared under contract for researchers in Europe, Asia and Australia. The range of products that have been manufactured is shown under the Vector and Cell Therapy Facilitypages. The facility is also accredited by the Foundation for the Accreditation of … Continue reading →

Autologous (autologous refers to cells, tissues or even growth factors that are re-implanted in the same individual as they come from, another words patient receives his or her own cells) cell therapy injections is a by-product of blood that is rich in Growth factors and platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the cells from the blood and the large amount of blood needed to produce a suitable quantity of cells. New technology permits the doctor to harvest and produce a sufficient quantity of cells from only 30-50 cc of blood drawn from the patient while they are in the office setting. It takes about 20 minutes to harvest these cells prior to injection. These cells allow the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the injected area in order to accelerate the healing process. These cells perform many functions, including release of growth factors (GF) into the diseased or arthritic and injured sites. Another main function is attracting Mesenchymal Stem Cells to the damaged area. These … Continue reading →

Celgene Cellular Therapeutics (CCT) is at the forefront of cell therapy research and development. Our lead cell therapy candidates are derived from healthy, full-term placenta, a remarkable organ shared by mother and baby. From this immunologically privileged source, we have generated novel cell therapy candidates with immunomodulatory, anti-inflammatory, angiogenic and reparative properties. CCTs placenta-derived adherent cells (PDAC cells) have been extensively characterized (see our Publications) and display multiple activities including the ability to stimulate natural repair processes, with the potential to transform the treatment of a broad range of serious debilitating diseases including autoimmune, vascular and neurodegenerative disorders. Specific formulations of PDAC cells are our lead clinical candidates PDA-001 (intravenous) and PDA-002 (intramuscular), currently in clinical trials for Crohns disease, Peripheral Artery Disease with Diabetic Foot Ulcer and other indications. Cell therapy research teams focus on the discovery and early development of novel cell-based therapeutics. We have developed a portfolio of unique clinical candidates with broad therapeutic potential, including human placenta-derived stem cells (HPDSC), natural killer (NK) cells and amnion-derived adherent cells (AMDAC cells). We are industry leaders in adult stem cell isolation, cell culture, characterization, functional interpretation and translational medicine. Our state-of-the-art in vitro, preclinical and translational biology approaches … Continue reading →

Meridian, Miss. Meet Champ, a 5 year old cocker spaniel who is full of life and love, but suffers from a ligament tear that hinders his mobility. Rather than have an invasive surgery which would require pain medications, Champs owners decided to go for an innovative procedure that will use his own cells to help heal and improve the tear. We are not going inside the joint per say or that kind of reconstruction, we are going to go inside the joint just to inject cells back in the joint, so that the body is allowed to use its own repair system to repair that ligament, explained Veterinarian Dr. Wayne Adams. Stem cell procedures previously took several days to complete, from extracting the cells and mailing them off to a lab, but now all of this can be done in house. We can digest the tissue, extract those dormant cells, and then we activate them with platelet plasma and low level laser light and then those cells are reintroduced back into that same pet in places of ailment, stated Trey Smith, Medivet Biologics. Stem cell procedures are becoming more mainstream in veterinary and human medicine, and are being used to … Continue reading →

Biology and Applications of CRISPR Systems: Harnessing Natures Toolbox for Genome Engineering Wright, AV; Nunez, JK; Doudna, JA Cell 2016-01-14 17.02 | Jan 18 Genome Editing Technologies for Gene and Cell Therapy Maeder, ML; Gersbach, CA Mol Ther 2016-01-12 17.02 | Jan 18 Deciphering CD137 (4-1bb) Signaling in T-Cell Costimulation for Translation into Successful Cancer Immunotherapy Sanchez-Paulete, AR; Labiano, S; Rodriguez-Ruiz, ME; Azpilikueta, A; Etxeberria, I; Bolaos, E; Lang, V; Rodriguez, M; Aznar, MA; Jure-Kunkel, M; Melero, I Eur J Immunol 2016-01-15 17.02 | Jan 18 Current Status of Treating Neurodegenerative Disease with Induced Pluripotent Stem Cells Pen, AE; Jensen, UB Acta Neurol Scand 2016-01-08 17.01 | Dec 11 Allogeneic Stem Cell Transplantation for Multiple Myeloma: Is There a Future? Dhakal, B; Vesole, DH; Hari, PN Bone Marrow Transplant 2016-01-04 17.01 | Dec 11 Stem Cell-Based Therapies to Promote Angiogenesis in Ischemic Cardiovascular Disease Hou, L; Kim, JJ; Woo, YJ; Huang, NF Am J Physiol Heart Circ Physiol 2015-12-18 17.00 | Jan 4 Allogeneic Stem Cell Transplantation for Multiple Myeloma: Is There a Future? Dhakal, B; Vesole, DH; Hari, PN Bone Marrow Transplant 2016-01-04 17.00 | Jan 4 Preclinical Modeling of Hematopoietic Stem Cell Transplantation: Advantages and Limitations Stolfi, JL; … Continue reading →

Adoptive T cell therapy involves the isolation and ex vivo expansion of tumor specific T cells to achieve greater number of T cells than what could be obtained by vaccination alone. The tumor specific T cells are then infused into patients with cancer in an attempt to give their immune system the ability to overwhelm remaining tumor via T cells which can attack and kill cancer. There are many forms of adoptive T cell therapy being used for cancer treatment; culturing tumor infiltrating lymphocytes or TIL, isolating and expanding one particular T cell or clone, and even using T cells that have been engineered to potently recognize and attack tumors. Our approach has been to utilize T cells taken directly from the patients blood after they have received a cancer vaccine. We have found by priming rare tumor antigen specific T cells first, with active immunization, we are much more able to expand those T cells in the laboratory to greater numbers for therapeutic infusion. A unique aspect to our approach for adoptive T cell therapy is the use of tumor specific CD4+ Th1 cells which may enhance anti-tumor efficacy. Adoptive T cell therapy strategies have largely focused on the … Continue reading →

Recommended For You 12oz Normal Hair Types seeking a balance of moisture and volume. The Balance System contains the Volume Therapy Shampoo to gently cleanse, Cell Therapy to treat and the Moisturizing Conditioner to hydrate strands for thicker, stronger, longer hair. The Balance System consists of three products to cleanse, treat, and moisturize. Apply Ovation Volume Therapy Shampoo to wet hair. Gently work into lather at the scalp and lightly massage through ends, then rinse. Follow with Ovation Cell Therapy Hair Treatment. Cell Therapy Routine Treatment: Use 2-3 times per week. Prepare hair by washing with an Ovation Shampoo. Massage Ovation Cell Therapy into scalp and comb through. Leave on for 3-5 minutes and rinse thoroughly. Apply Ovation Moisturizing Conditioner following Ovation Volume Therapy Shampoo or Ovation Cell Therapy Hair & Scalp Treatment. Gently massage through hair. Rinse thoroughly. Style as desired. I have very fine hairs along my forehead (part of my bangs) that are so fragile that they break and do not grow! With Ovation, I can finally see a difference in their length!! My husband uses Ovation also! Susan J. Absolutely I have noticed a difference in my hair since I started using Ovation! My hair was … Continue reading →

Recommended For You 12oz Normal Hair Types seeking a balance of moisture and volume. The Balance System contains the Volume Therapy Shampoo to gently cleanse, Cell Therapy to treat and the Moisturizing Conditioner to hydrate strands for thicker, stronger, longer hair. The Balance System consists of three products to cleanse, treat, and moisturize. Apply Ovation Volume Therapy Shampoo to wet hair. Gently work into lather at the scalp and lightly massage through ends, then rinse. Follow with Ovation Cell Therapy Hair Treatment. Cell Therapy Routine Treatment: Use 2-3 times per week. Prepare hair by washing with an Ovation Shampoo. Massage Ovation Cell Therapy into scalp and comb through. Leave on for 3-5 minutes and rinse thoroughly. Apply Ovation Moisturizing Conditioner following Ovation Volume Therapy Shampoo or Ovation Cell Therapy Hair & Scalp Treatment. Gently massage through hair. Rinse thoroughly. Style as desired. I have very fine hairs along my forehead (part of my bangs) that are so fragile that they break and do not grow! With Ovation, I can finally see a difference in their length!! My husband uses Ovation also! Susan J. Absolutely I have noticed a difference in my hair since I started using Ovation! My hair was … Continue reading →

Stem Cell Therapy Plus is also called Cell Therapy or Regenerative Medicine. Anecdotal evidence shows that through the usage of Stem Cell Therapy Plus, improvements can be seen in the following cases of degenerative diseases: Learn More Stem cells are cells with the ability to divide for indefinite periods in culture and to give rise to specialized cells. Stem cells have the remarkable potential to develop into many different cell types. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a nerve cell, or a brain cell. Stem Cell Supplements are developed based on the merits of stem cells and they are applied for degenerative diseases treatments and to stimulate the formation of all the different tissues of the body: muscle, cartilage, tendon, ligament, bone, blood, nerve, organs, etc. Stem Cell Supplements bring essential anti-ageing, health & beauty benefits by providing necessary elements to the body to improve cellular regeneration, organ rejuvenation and tissue … Continue reading →

Neon Therapeutics Enters Collaborative Research Agreement with the Netherlands Cancer Institute Neon Therapeutics announced that the company has entered into a collaborative research agreement with the Netherlands Cancer Institutes (NKI) Antoni van Leeuwenhoek Hospital and the Amsterdam Biotherapeutics Unit. Under the terms of the agreement, Neon Therapeutics and NKI will combine complementary capabilities to develop personalized T cell therapeutics. [Neon Therapeutics] PressRelease Juno Therapeutics, Seattle Cancer Care Alliance and Fred Hutchinson Cancer Research Center Announce New Immuno-Oncology Clinical Trials Unit Juno Therapeutics, Inc. and Fred Hutchinson Cancer Research Center announced the creation of a new, best-in-class clinical trials unit dedicated to immuno-oncology. [Juno Therapeutics, Inc.] PressRelease OncBioMune Continuing Phase I Trial, While Initiating Phase II Trial of ProscaVax for Prostate Cancer OncBioMune Pharmaceuticals, Inc. reported positive results from its Phase I clinical trial of ProscaVax, the companys novel cancer vaccine for prostate cancer. [OncBioMune Pharmaceuticals, Inc.] PressRelease Asterias Biotherapeutics Announces Successful End-of-Phase II Meeting with FDA for AST-VAC1 Asterias Biotherapeutics, Inc. announced the successful completion of an End-of-Phase II meeting with the U.S. Food and Drug Administration (FDA) for AST-VAC1, its investigational therapy targeting acute myeloid leukemia. [Asterias Biotherapeutics, Inc.] PressRelease Capricor Therapeutics Announces the First Patient with Duchenne Muscular … Continue reading →