Category Archives: Cell Therapy

In the new treatment, specialists use a high dose of chemotherapy to knock out the immune system before rebuilding it with stem cells taken from the patients own blood. Stem cells are so effective because they can become any cell in the body based on their environment. "Since we started treating patients three years ago, some of the results we have seen have been miraculous," Professor Basil Sharrack, a consultant neurologist at Sheffield Teaching Hospitals NHS Foundation Trust, told The Sunday Times. "This is not a word I would use lightly, but we have seen profound neurological improvements." During the treatment, the patient's stem cells are harvested and stored. Then doctors use aggressive drugs which are usually given to cancer patients to completely destroy the immune system. The harvested stem cells are then infused back into the body where they start to grow new red and white blood cells within just two weeks. Within a month the immune system is back up and running fully and that is when patients begin to notice that they are recovering. Holly Drewry, 25, of Sheffield, was wheelchair bound after the birth of her daughter Isla, now two. But she claims the new treatment … Continue reading →

New York City--A novel phase 1 clinical trial that leverages T-cell immunotherapy is now under way at Karmanos Cancer Institute (KCI) in Detroit and Memorial Sloan-Kettering Cancer Center in New York City; bringing new hope to children and young adults with osteosarcoma and neuroblastoma. This new clinical trial is being funded by charity partners Solving Kids' Cancer and Fishin' For The Cure. T-cell therapy to treat both adult and childhood cancers has been in recent news for the dramatic responses seen in some patients, who've experienced a complete remission or have no more cancer cells in their body. A type of immunotherapy, T-cell therapy trains a patient's own white blood cells that are collected and engineered to recognize specific targets on the surface of cancer cells. These "armed" T-cells are cloaked with a bi-specific T-cell engaging antibody (BiTE) using a new humanized antibody called hu3F8, and returned to the patients as a vaccine with one mission, kill cancer cells. Scientists believe that by incorporating this BiTE antibody, the T-cells will be more effective. "Children and young adults battling osteosarcoma and neuroblastoma need curative treatment options after chemotherapy and targeted drugs stop working," said Tracy Russo, the Executive Director of Fishin' … Continue reading →

Bengaluru:Feb 27, 2015, DHNS Two courses of stem cell therapy have helped Ashok Kumar, 59, who suffered from tremors and rigidity due to Parkinsons disease, recover completely, much to the joy of his family. The man was brought inside my cabin in a wheelchair. He was unable to even sit on the chair without support. Today, he walks independently. Stem cell therapy has made it possible for him, said Dr Naseem Sadiq, Director, Plexus Neuro and Stem Cell Research Centre, who began treating Kumar in October, last year. Previously, medication and surgical procedure were the only treatment option for Parkinsons disease. Medication in the long-term often lacks effectiveness and may cause side effects, while surgery is not always feasible. Lately, stem cell therapy has turned out to be a boon for patients with Parkinsons, Dr Sadiq said. Kumar is among the few who have benefited from stem cell therapy. However, though the State has been reporting an increase in the number of registered stem cell donors, it is far behind sufficient as the genetic match between donor and recipient could be anywhere between one in 10,000 and one in two million, according to experts. Speaking to Deccan Herald, Raghu Rajgopal, … Continue reading →

A clinical trial using T-cell therapy that uses the patients' own immune cells to hunt down cancer cells is now being offered at the University of Michigan's C.S. Mott Children's Hospital. "For patients for whom we've exhausted all other options, this therapy has provided hope against a highly aggressive form of ALL, in situations where nothing else has been successful," says John Levine, M.D., clinical director of the Pediatric Blood and Marrow Transplantation Program at C.S. Mott Children's Hospital. To begin the treatment process, researchers first extract a patient's own T cells. They then use bioengineering techniques to reprogram each patient's T cells into chimeric antigen receptor cells -- the CTL019 cells -- custom-designed to bind to a protein called CD19 that exists only on the surface of B cells. After being returned to the patient's body, the CTL019 cells proliferate and then hunt B cells that express CD19. They also may persist in the circulation, which may guard against the cancer's recurrence. "We are very proud to play an active role in this exciting new research that can offer new breakthroughs and hope for our pediatric cancer patients," says Levine, a professor of pediatrics in the University of Michigan … Continue reading →

Contact Information Available for logged-in reporters only Newswise ANN ARBOR, Mich. A clinical trial using T-cell therapy that uses the patients own immune cells to hunt down cancer cells is now being offered at the University of Michigans C.S. Mott Childrens Hospital. For patients for whom weve exhausted all other options, this therapy has provided hope against a highly aggressive form of ALL, in situations where nothing else has been successful, says John Levine, M.D., clinical director of the Pediatric Blood and Marrow Transplantation Program at C.S. Mott Childrens Hospital. To begin the treatment process, researchers first extract a patients own T cells. They then use bioengineering techniques to reprogram each patients T cells into chimeric antigen receptor cells the CTL019 cells custom-designed to bind to a protein called CD19 that exists only on the surface of B cells. After being returned to the patients body, the CTL019 cells proliferate and then hunt B cells that express CD19. They also may persist in the circulation, which may guard against the cancers recurrence. We are very proud to play an active role in this exciting new research that can offer new breakthroughs and hope for our pediatric cancer patients, says Levine, … Continue reading →

Dr Ellis hosts seminar on Stem Cell Therapy Facial Rejuvenation Dr. Dan Eglinton of Asheville Biologics and Orthopaedics, Dr. Sean Whalen and Dr. Paul Mogannam of Flexogenics and Dr. Laura Ellis of medAge speak about Stem Cell Therapy and skin ... By: Dr. Laura Ellis … Continue reading →

Team BASIC LaunchUMD This video is about Team BASIC, a Junior Gemstone Team, and their project on the efficacy of pH manipulation on Adoptive Cell Therapy. This video was made as part of their LaunchUMD campaign. By: Julia W … Continue reading →

Comment: T cell therapy for children with aggressive leukaemia Visit http://www.ecancer.org for more. Dr Bollard (George Washington University, Washington, USA) discusses key abstracts showcased at ASH 2014 with ecancertv. Here, she talks about Dr Stephan... By: ecancer medicalscience … Continue reading →

Children with aggressive leukaemia experiencing remission with T cell therapy Visit http://www.ecancer.org for more. Dr Grupp (The Children's Hospital of Philadelphia, Philadelphia, USA) talks to ecancertv at ASH 2014 about the use of T cell therapy for children with... By: ecancer medicalscience … Continue reading →

DUBLIN, Feb .10, 2015 /PRNewswire/ --Research and Markets (http://www.researchandmarkets.com/research/7zf9mz/cell_therapy) has announced the addition of Jain PharmaBiotech's new report "Cell Therapy - Technologies, Markets and Companies" to their offering. This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice. Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation. Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. … Continue reading →