Category Archives: DNA

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Pancreatic cancer cells dividing. Random mutations in DNA are behind two thirds of adult cancers, a study says. Photograph: Visuals Unlimited, Inc./Dr. Stan/Getty Images/Visuals Unlimited Most cases of cancer are largely the result of bad luck rather than unhealthy lifestyles, diet or inherited genes, new research suggests. Random mutations that occur in DNA when cells divide are largely responsible for two thirds of adult cancers across a wide range of tissues. The remaining third are linked to environmental factors or defective inherited genes. But the scientists warn that poor lifestyle can add to the bad luck factor involved in cancer. The researchers analysed published data on the number of divisions of self-renewing stem cells that occur in an average lifetime in 31 different tissues. These results were compared with the lifetime incidence of cancer in the same tissues. A strong correlation was seen between a particular tissues stem cell division rate and its likelihood of developing cancer. The more often cells divide, the more likely it is that letters of their genetic code will become jumbled, leading to an increased cancer risk. Overall, the study found that random mutations due to stem cell division could largely explain around 65% of … Continue reading →

How would your Welsh Ancestry look? HAVE you ever wondered where your ancestors came from? As part of a new TV series, DNA Cymru,people in Llanelli are being given the chance to trace their geneticroots. The team will be at Parc y Scarlets on Saturday ahead of the Ospreys clash offering more information about the project and giving people the chance to win a freeAncestral DNA testing kit. Series producer Angela Graham of Green Bay Media explains, We are attempting an unprecedented mass survey of Welsh DNA to throw light on movements of population in the past and find answers to some historical puzzles. Two of S4Cs DNA Cymrupresenters, Beti George and Dr Anwen Jones, will be at Parc y Scarlets to help explain some of the questions through the testing of ancestral DNA. The series, which airs on S4C onMarch 1,presents the journey of humanity from its origins in Africa to the earliest populations of the land we now know as Wales, right up the inhabitants of todays Wales. In the series, presenters Beti George, Dr Anwen Jones and Jason Mohammad will be explaining how the science of DNA can reveal genetic blueprints that stretch back beyond recorded history. … Continue reading →

Cholera is caused when the bacterium Vibrio cholerae infects the small intestine. The disease is characterized by acute watery diarrhea resulting in severe dehydration. EPFL scientists have now demonstrated that V. cholerae uses a tiny spear to stab and kill neighboring bacteria -- even of its own kind -- and then steal their DNA. This mechanism, known as "horizontal gene transfer," allows the cholera bacterium to become more virulent by absorbing the traits of its prey. The study is published in Science. The lab of Melanie Blokesch at EPFL has uncovered how V. cholerae uses a predatory killing device to compete with surrounding bacteria and steal their DNA. This molecular killing device a spring-loaded spear that is constantly shooting out. This weapon is called the "type VI secretion system" (T6SS) and is known to exist in many types of bacteria. When V. cholerae comes close to other bacteria, the spear punches a hole into them, leaving them to die and release their genetic material, which the predator pulls into itself. Killing neighbors and stealing genes This spear-killing, predatory behavior is triggered by the bacterium's environment. The cholera bacterium naturally lives in water, such as the sea, where it attaches onto … Continue reading →

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