Category Archives: DNA

GH3PC - DNA Uber Solo 385K I could probably get 400K but it would require too much effort. By: Ghn00b1 … Continue reading →

Deoksiribonkleik asit veya ksaca DNA, tm organizmalar ve baz virslerin canllk ilevleri ve biyolojik gelimeleri iin gerekli olan genetik talimatlar tayan bir nkleik asittir. DNA'nn balca rol bilginin uzun sreli saklanmasdr. Protein ve RNA gibi hcrenin dier bileenlerinin inas iin gerekli olan bilgileri iermesinden dolay DNA; bir kalp, ablon veya reeteye benzetilir. Bu genetik bilgileri ieren DNA paralar gen olarak adlandrlr. Ama baka DNA dizilerinin yapsal ilevleri vardr (kromozomlarn eklini belirlemek gibi), dierleri ise bu genetik bilginin ne ekilde (hangi hcrelerde, hangi artlarda) kullanlacann dzenlenmesine yararlar. Kimyasal olarak DNA, nkleotit olarak adlandrlan basit birimlerden oluan iki uzun polimerden oluur. Bu polimerlerin omurgalar, ester balar ile birbirine balanm eker ve fosfat gruplarndan meydana gelir. Bu iki iplik birbirlerine ters ynde uzanrlar. Her bir eker grubuna baz olarak adlandrlan drt tip moleklden biri baldr. DNA'nn omurgas boyunca bu bazlarn oluturduu dizi, genetik bilgiyi kodlar. Protein sentezi srasnda bu bilgi, genetik kod araclyla okununca proteinlerin amino asit dizisini belirler. Bu sre srasnda DNA'daki bilgi, DNA'ya benzer yapya sahip baka bir nkleik asit olan RNA'ya kopyalanr. Bu ileme transkripsiyon denir. Hcrelerde DNA, kromozom olarak adlandrlan yaplarn iinde yer alr. Hcre blnmesinden evvel kromozomlar elenir, bu srada DNA ikilemesi gerekleir. karyot canllar (yani hayvan, bitki, … Continue reading →

Over the last several decades, DNA the genetic material of life as we know it has completed a remarkable scientific cycle. In 1953, it was a mysterious blur on an X-ray diffractogram. By the 1970s, it was possible to determine the sequence of short nucleotide chains. And now, a scientist can produce her own genetic code of choice with the click of a mouse. What happens after the mouse click, after an order for a chain of DNA is sent, is an impressive series of events that represents one of the most mature, yet dynamic, sectors of the biotech industry. DNA synthesis companies range from scrappy start-ups to Cambridge-area behemoths, each touting a distinct set of tools that carves out a slice of the ever increasing pie. For many groups, the human genome project the $3 billion effort funded by the U.S. government was an important launching point that both advanced DNA sequencing and synthesis technology and prompted important questions worthy of further scientific investigation. We are a direct beneficiary of all the sequencing information that came out of the Project, says Kevin Munnelly, CEO of Gen9, and its all going to impact synthetic biology and our ability to write … Continue reading →

DNA production is becoming cheaper than ever, propelled down a Moores law curve by maturing technologies and cheaper reagents. This new biosynthetic industry allows researchers to order up a customized sequence for overnight delivery. But many users dont just want a chain of nucleotides, they want ready-to-use sequences that can be inserted into a cell to make a product of interest. Such DNA products, known as constructs, include two components a vector that will be read by host machinery and initiate transcription, and an inserted gene that will generate the non-native biomolecule. Constructs can be thousands of bases in length, but once theyre uploaded to the cell, production should be good to go. This niche is where Genscript is staking its claim. Were the worlds largest provider for construct based gene synthesis, says Jeffrey Hung, a Genscript Vice President, and a lot of our growth is coming from higher demand for biologics, or medicinal biomolecules generated through a microbial host (as opposed to an exclusively chemical synthetic process). Most frequently, the company takes orders for non-native products to be expressed in a different organism, turning the unwitting target cell into a biofactory for recombinant proteins or antibodies. In many cases, … Continue reading →

Researcher from Lomonosov Moscow State University managed to clarify how DNA damage signaling works Credit: Courtesy of Tom Ellenberger, Washington University School of Medicine in St. Louis The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. The DNA damage response is immensely important, for example, for ensuring the highest possible quality of the DNA before replication - duplication of the DNA prior to cell division. If the damaged DNA is replicated, the risk of cancer and other diseases increases significantly due to mutations. All in all this may lead to the death of a cell itself. DNA repair consists of enzymes which find the damaged DNA and repair it before the replication. These enzymes work differently. Some of them recognize the damaged bases and give signals to the other enzymes, which repair the DNA. Ataxia-telangiectasia mutated (ATM) is a kinase that transmits the signal from damaged DNA to cellular repair systems. Scientists used to think that ATM exclusively recognizes DNA double-strand breaks (DSBs). These breaks are extremely dangerous because they may lead to the loss of genetic … Continue reading →

gallery_thumbnails_photo|photo-7743958|article-gallery-6169230|1 gallery_thumbnails_photo|photo-7743959|article-gallery-6169230|2 gallery_thumbnails_photo|photo-7721535|article-gallery-6169230|3 Photo: Liz Hafalia / The Chronicle gallery_thumbnails_show|article-gallery-6169230|article-gallery-6169230|0 gallery_overlay_open|article-gallery-6169230|article-gallery-6169230|0 gallery_overlay_open_thumbs|article-gallery-6169230|article-gallery-6169230|0 Police Chief Greg Suhr, seen in December, said Monday that authorities were looking at 1,400 criminal cases that were prosecuted in part based on DNA work done by a technician identified in court records as Mignon Dunbar and her supervisor, Cherisse Boland. Both are civilian police employees. Police Chief Greg Suhr, seen in December, said Monday that... Lab director Jim Mudge shows criminalist Deborah Maddens work station at the police crime lab in San Francisco in March 2010. Madden was accused of stealing cocaine that was used as criminal evidence by prosecutors. Lab director Jim Mudge shows criminalist Deborah Maddens work... Public defender Jeff Adachi plays audio at the S.F. Public Defender's Office, Thursday, March 26, 2015, in San Francisco, Calif. The audio is a testimony of an inmate saying that S.F. sheriff deputies are staging cage-fight style matches between inmates for their entertainment and gambling purposes. Follow this link: Technician, boss in SFPD lab scandal flunked DNA skills exam … Continue reading →

A forensic scientist has told a murder trial he has discounted the fact that DNA profiles from two women killed nearly 20 years ago were found on the sleeve of a jacket belonging to the murder accused. Mark Nash has pleaded not guilty at the Central Criminal Court to the murder of Sylvia Shields and Mary Callanan between March 6-7, 1997. The court had previously heard that a profile taken from the button threads of the right sleeve of the black velvet jacket matched Ms Shields DNA profile and a DNA profile obtained from a particle found inside the seam of the right sleeve of the jacket also matched Ms Callanan. Reading Philip Avenells conclusion, Brendan Grehan, prosecuting, said: Considering all of the information, it remains my view, there is a real possibility that the scientific findings may have arisen because of contamination in the scientific lab. To which Mr Grehan replied: Im suggesting the most likely explanation is that, to have both DNAs belonging to both victims on the sleeve, is because he was there at the scene. You havent supported your opinion with any proper scientific basis which can be evaluated and furthermore it is of great significance … Continue reading →

A forensic scientist in the trial of Mark Nash for the murder of two women in 1997 told the court that he has discounted the fact that DNA profiles from the women were found on the sleeve of a jacket belonging to the murder accused. Mr Nash, 42, who has last addresses at Prussia Street and Clonliffe Road in Dublin,pleaded not guilty at the Central Criminal Court to the murder of 60-year-old Sylvia Shields and Mary Callanan, 61, between 6 and 7 March 1997. The two women were living in sheltered accommodation in a house attached to St Brendan's Psychiatric Hospital in Grangegorman at the time of their murders. Dr Philip Avenell told the court he had compared two hypotheses, one considering whether the DNA results were obtained when the jacket was present at the murders and another whether the DNA results were obtained when the jacket was seized. He said that reading from his report he was "unable to determine which proposition was more likely." The court previously heard that a profile taken from the buttonthreads of the right sleeve of the black velvet jacket matched Ms Shields'DNA profile and a DNA profile obtained from a "particle" found inside … Continue reading →

CALL OF DUTY AW DOUBLE DNA BOMB W/O SCAVENGER SOLO DNA - https://www.youtube.com/watch?v=bdV6vwQtesQ BTL ReallyNooob: Why he streams https://www.youtube.com/watch?v=9ILxzxSLUS4 Subscribe for more COD content. Please leave a ... By: BTL Stream Team … Continue reading →

Advanced warfare DNA Bomb! 1st video This is my 1st video. There will be more content on the way. If you could subscribe it would be appreciated. Thank you. By: Ebmj08 … Continue reading →