Category Archives: Gene Medicine

Gene therapy is a rapidly growing field of medicine in which genes are introduced into the body to treat diseases. Genes control heredity and provide the basic biological code for determining a cell's specific functions. Gene therapy seeks to provide genes that correct or supplant the disease-controlling functions of cells that are not, in essence, doing their job. Somatic gene therapy introduces therapeutic genes at the tissue or cellular level to treat a specific individual. Germ-line gene therapy inserts genes into reproductive cells or possibly into embryos to correct genetic defects that could be passed on to future generations. Initially conceived as an approach for treating inherited diseases, like cystic fibrosis and Huntington's disease, the scope of potential gene therapies has grown to include treatments for cancers, arthritis, and infectious diseases. Although gene therapy testing in humans has advanced rapidly, many questions surround its use. For example, some scientists are concerned that the therapeutic genes themselves may cause disease. Others fear that germ-line gene therapy may be used to control human development in ways not connected with disease, like intelligence or appearance. Gene therapy has grown out of the science of genetics or how heredity works. Scientists know that life … Continue reading →

Gene Medicine TherapyMarketanalysis is provided for global market including development trends by regions, competitive analysis of Gene Medicine Therapymarket. The Gene Medicine Therapyindustry report firstly announced the Gene Medicine TherapyMarket fundamentals: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Gene Medicine TherapyMarket split by Application Application 1, Application 2, Application 3. Gene Medicine TherapyMarket Segment by Regions (North America, Europe and Asia-Pacific) and the main countries(United States, Germany, United Kingdom, Japan, South Korea and China). Through the statistical analysis,the Gene Medicine TherapyMarket report depicts the global Industry Analysis, Manufacturers Analysis, Gene Medicine TherapyIndustry Development Trend, Sales Demand and Forecast to 2021. Get PDF Sample of Gene Medicine TherapyMarket Report @ https://www.absolutereports.com/enquiry/request-sample/10682285 Table of Contents: Chapter 1: Gene Medicine TherapyMarket Overview 1.1 Definition 1.2 Classification Analysis 1.3 Application Analysis 1.4 Gene Medicine TherapyIndustry Chain Structure Analysis 1.5 Gene Medicine TherapyMarket Development Overview 1.6 Global Gene Medicine TherapyMarket Comparison Analysis 1.6.1 Global Import Market Analysis 1.6.2 Global Export Market Analysis 1.6.3 Global Main Region Market Analysis 1.6.4 Global Market Comparison Analysis 1.6.5 Global Market Development Trend Analysis Chapter 2:Gene Medicine TherapyUp and Down Stream Industry Analysis 2.1 Upstream Raw Materials Analysis of Gene … Continue reading →

Welcome to the website of the Oxford University Gene Medicine Research Group. We are a University of Oxford research group based in the Radcliffe Department of Medicine at the John Radcliffe Hospital. We are focused on the development of clinical gene therapies for the treatment of lung diseases. Our primary focus has been Cystic Fibrosis (CF) lung disease. Together with colleagues at the University of Edinburgh and Imperial College London we form the UK Cystic Fibrosis Gene Therapy Consortium, funded by the Medical Research Council, the National Institute for Health Research and the UK Cystic Fibrosis Trust. The Consortium is currently undertaking one of the world's largest ever gene therapy clinical trials in CF patients based on our gene therapy research. Patient Recruitment for the Muti-Dose Clinical Trial We are pleased to announce the launch of new charity Just Gene Therapy with the specific aim of raising funds for gene therapy research for CF. The charity has been established by Rosie Barnes in conjunction with Professor Eric Alton, and is the only way in which donations can directly support the work of the Consortium. See the original post: UK Cystic Fibrosis Gene Therapy Consortium : Oxford ... … Continue reading →

Description: Professor David Porteous predicts that gene medicines such as gene therapy will improve the effectiveness of treating psychiatric disorders. Transcript: I use the phrase 'gene medicine' to refer to medicines that are developed through gene knowledge. They come in lots of different forms. A classic form, if you like, is gene therapy where you actually use the gene itself as a form of therapeutic to manufacture a damaged protein that an individual may be lacking. But more broadly, and I think more relevant to the area of schizophrenia, is the idea of using gene knowledge to make more rational forms of treatment. Now just take the example of having identified a gene a risk factor in schizophrenia and that risk factor turns out to have something to do with the way in which we receive signals in the brain and that process is disordered. If we can understand that basis of that, we can start making much more finely tuned pharmaceuticals than we currently use and ones with far fewer side effects, which is one of the biggest problems in this area. So reducing side effects and improving the effectiveness of treatments is something which I believe will come … Continue reading →

Welcome to The Journal of Gene Medicine Clinical Trial site, the most comprehensive source of information on worldwide gene therapy clinical trials available on the internet. From this page you may access the following: Charts and Tables Charts and tables showing the number of approved, ongoing or completed clinical trials worldwide. Data is available for: Interactive Database A database with detailed information on individual trials. Data search is available for: The data were compiled and are regularly updated from official agency sources (RAC, GTAC etc..), the published literature, presentations at conferences and from information kindly provided by investigators or trial sponsors themselves. Information on the trials performed in the United States is derived directly from the OBA/RAC website. Elsewhere, the information is not so readily available. and in some countries regulatory agencies simply do not disclose any information. Consequently, information on some trials is incomplete. We have adopted as standard procedure the inclusion of all trials where the country and disease addressed is known, even if no other details are available. While it is not entirely satisfactory to have information missing on the type of gene used and the vector etc..., it does have the advantage of providing a more … Continue reading →

ACGT Savio Woo Tribute Upon his retirement as Founding Chair, Cell and Gene Medicine at Mt. Sinai and as Founding Chair, ACGT's Scientific Advisory Council, ACGT proudly celebrates the distinction of the long... By: ACGTFoundation … Continue reading →

Drug Des Devel Ther. 2008; 2: 115122. Published online Feb 6, 2009. 1 Division of Pathology, Chiba Cancer Center Research Institute 2 Division of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan 3 Department of Environmental Biochemistry 4 Department of Diagnostic Pathology 5 Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan Loss of p53 function compromises genetic homeostasis, which induces deregulated DNA replication, damages DNA, and subsequently results in increased resistance to anticancer agents. Pharmacological approaches using recombinant adenoviruses (Ad) have been developed to restore the p53 functions. Another approach for gene medicine is to modify Ad replication in a tumor-specific manner, which induces tumor cell death without damaging normal tissues in the vicinity. The Ad-derived gene medicines, Ad expressing the wild-type p53 gene and replication-competent Ad defective of the E1B-55kDa gene, have been tested for their clinical feasibility and became commercially available in China. These agents demonstrated their antitumor activities as a monotherapy and in combination with conventional chemotherapeutic agents. In this article, we summarize the outcomes of clinical trials in China, most of which have been published in domestic Chinese journals, and discuss potential directions of cancer gene therapy with these agents. Keywords: gene therapy, cancer, … Continue reading →

Gene medicine is making breakthroughs for health questions that have baffled humanity for centuries. Gene therapy is the applicable aspect of the science of gene medicine. Treatments are being developed that can reverse genetic diseases at the molecular level. Health questions that have previously be unanswered are now being solved. Health questions like how to remedy chronic pain are now being clinically tested and the gene therapy is already showing substantial subsiding of pain for the clinical trial patients. As countries put more funding into gene medicine, and more collaboration takes place between those countries, many of the health questions that we have today will be answered in the next decade Gene medicine is one of the medical disciplines that affect all aspects of human health. From allergies, bone growth and cell development. Gene medicine is also one of the most mysterious to those with health questions as the science is only recognized in the media when discoveries are made. However, research is going on everyday in the field of gene medicine and breakthroughs, while they dont happen everyday, are happening more often. Gene medicine is beginning to look deeper into how dieseases can be blocked, removed and altered using … Continue reading →

BALTIMORE, Md. via PRWEB Today Insilico Medicine, Inc., a Baltimore-based company using advances in genomics to discover new therapies to target aging and age-related diseases, announced the appointment .. Continue reading Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report. The researchers found that cancers with a mutation in the BRAF gene require copper to promote tumor growth. These tumors include melanoma, the most dangerous form of skin cancer that kills an estimated 10,000 people in the United States a year, according to the National Cancer Institute. Continue reading A new study shows that a gene discovered 30 years ago and now known to play a fundamental role in cancer development produces five different gene variants (called isoforms), rather than just the one original form, as thought. The study of the NRAS gene by researchers at The Ohio State University Comprehensive Cancer Center Arthur G Continue reading Stanford University researcher Irving Weissman explains how the drug Rituxan, generically called rituximab, improves the cancer-killing effect of a new antibody that renders cancer cells vulnerable to immune attack. He spoke Monday, April … Continue reading →

A study that made its way from the Middle East to New York has identified a gene mutation found in those of African descent, shedding some light on why a significant number of black people are predisposed to certain diseases. NY1's Erin Billups filed the following report. Too much fat or triglycerides in the blood stream leads to heart disease, type 2 diabetes, obesity and stroke are all diseases that are are found at higher rates among people of African ancestry. Ronald Crystal, chair of Genetic Medicine at Weill Cornell Medical College, says they've found a genetic variation they believe is partially responsible. "When we looked at the medical literature we found that it had been discovered 20 years ago but was thought to be a very rare mutation," says Dr. Crystal. It turned out this mutation of a protein gene called Apo-E was relatively common among people native to the Middle Eastern country Qatar. "Apo-E is a gene that we all have. It codes for a protein that helps us carry fats in our blood," explains Dr. Crystal. The mutation they discovered in Qatari with African ancestry increases the amount of fat in the blood. "So we then looked … Continue reading →