Category Archives: Mesenchymal Stem Cells

Regenevda recently opened its brand new flagship facility in Beverly Hills, specializing in cutting edge anti-aging treatments such as Stem Cell Therapy. Beverly Hills, CA (PRWEB) October 12, 2012 Dr. Thom Lobe is an internationally respected surgeon and has been in practice for over 30 years. Consistently pioneering advances in medicine, Dr. Lobe was one of the first doctors to ever separate conjoined twins. Consistently working to help make advances in medicine, Dr. Lobe also has over 200 publications to his credit. Overseeing the business aspect of Regenevda is Lindsey Combs. She is responsible for sales, staff, accounting, facility management, and business development. A graduate of the University of California, Los Angeles, Ms. Combs has been working in the anti-aging field for over 10 years and has been a California Licensed Esthetician since 2003. Being one of the very few physicians in the country to hold the most advanced board certification (FAARM), Dr. Lobe is able to offer Stem Cell Therapy at the Regenevda clinic. Inside each persons own body, there are special cells in nearly every organ and tissue that have the ability to help heal damage. These special cells are called Stem Cells and this therapy works by … Continue reading →

Public release date: 11-Oct-2012 [ | E-mail | Share ] Contact: Bonnie Prescott bprescot@bidmc.harvard.edu 617-667-7306 Beth Israel Deaconess Medical Center BOSTON In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority of the tumor mass, form what is known as the "tumor microenvironment." This sea of noncancerous cells and the products they deposit appear to play key roles in tumor pathogenesis. Among the key accomplices in the tumor microenvironment are mesenchymal stem cells (MSCs), a group of adult progenitor cells which have been shown to help breast cancers maneuver and spread to other parts of the body. Now, new research sheds further light on how this is happening. Led by investigators at Beth Israel Deaconess Medical Center (BIDMC), the findings demonstrate that the lysyl oxidase (LOX) gene is spurred to production in cancer cells as a result of their contact with MSCs, and once produced, can help ensure the spread of otherwise weakly metastatic cancer cells from primary tumors to the lung and bones. Described on-line in the Proceedings of the National Academy of Sciences (PNAS), this discovery … Continue reading →

ScienceDaily (Oct. 11, 2012) In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority of the tumor mass, form what is known as the "tumor microenvironment." This sea of noncancerous cells and the products they deposit appear to play key roles in tumor pathogenesis. Among the key accomplices in the tumor microenvironment are mesenchymal stem cells (MSCs), a group of adult progenitor cells which have been shown to help breast cancers maneuver and spread to other parts of the body. Now, new research sheds further light on how this is happening. Led by investigators at Beth Israel Deaconess Medical Center (BIDMC), the findings demonstrate that the lysyl oxidase (LOX) gene is spurred to production in cancer cells as a result of their contact with MSCs, and once produced, can help ensure the spread of otherwise weakly metastatic cancer cells from primary tumors to the lung and bones. Described on-line in the Proceedings of the National Academy of Sciences (PNAS), this discovery not only provides key insights into the basic biology of tumor formation, but also offers a potential … Continue reading →

The Nobel Prize for Physiology or Medicine was announced on Monday. The award this year went to Sir John B. Gurdon and Dr. Shinya Yamanaka. The two men were awarded the Nobel Prize jointly, for their individual work in cloning and stem cell research. Monday's recognition marked the awarding of the first Nobel Prize for 2012. The rest of the Nobel Prize recipients will be announced throughout the next two weeks. Here is some of the key information regarding Gurdon and Yamanaka's work and Monday's Nobel Prize announcement. * Yamanaka and Gurdon did not work together or present shared research, even though they both concentrate their studies on a similar area of research. * Gurdon is actually being honored for work he did back in 1962. According to a New York Times report, he was the first person to clone an animal, a frog, opening the door to further research into stem cells and cloning. * Gurdon was able to produce live tadpoles from the adult cells of a frog, by removing the nucleus of a frog's egg and putting the adult cells in its place. * This "reprogramming" by Gurdon laid the groundwork for Yamanaka's work four decades later. … Continue reading →

Stem cell transfusions may someday replace the need for transplants in patients who suffer from liver failure caused by hepatitis B, according to a new study coming out of Beijing. . The results are published in the October issue of STEM CELLS Translational Medicine. Worldwide more than 500,000 people die each year from this condition. Durham, NC (PRWEB) October 11, 2012 In China, hepatitis B virus (HBV) infection accounts for the highest proportion of liver failure cases. While liver transplantation is considered the standard treatment, it has several drawbacks including a limited number of donors, long waiting lists, high cost and multiple complications. Our study shows that mesenchymal stem cell (MSCs) transfusions might be a good, safe alternative, said Fu-Sheng Wang, Ph.D., M.D., the studys lead author and director of the Research Center for Biological Therapy (RCBT) in Beijing. Wang along with RCBT colleague, Drs. Ming Shi and Zheng Zhang of the Research Center for Biological Therapy, The Institute of Translational Hepatology led the group of physician-scientists from the centers and Beijing 302 Hospital who conducted the study. MSC transfusions had already been shown to improve liver function in patients with end-stage liver diseases. This time, the researchers wanted to … Continue reading →

Nobel laureate Shinya Yamanaka warned patients on Tuesday about unproven "stem cell therapies" offered at clinics and hospitals in a growing number of countries, saying they were highly risky. The Internet is full of advertisements touting stem cell cures for just about any disease -- from diabetes, multiple sclerosis, arthritis, eye problems, Alzheimer's and Parkinson's to spinal cord injuries -- in countries such as China, Mexico, India, Turkey and Russia. Yamanaka, who shared the Nobel Prize for Medicine on Monday with John Gurdon of the Gurdon Institute in Cambridge, Britain, called for caution. "This type of practice is an enormous problem, it is a threat. Many so-called stem cell therapies are being conducted without any data using animals, preclinical safety checks," said Yamanaka of Kyoto University in Japan. "Patients should understand that if there are no preclinical data in the efficiency and safety of the procedure that he or she is undergoing ... it could be very dangerous," he told Reuters in a telephone interview. Yamanaka and Gurdon shared the Nobel Prize for the discovery that adult cells can be transformed back into embryo-like stem cells that may one day regrow tissue in damaged brains, hearts or other organs. "I … Continue reading →

LA JOLLA, Calif., Oct. 10, 2012 /PRNewswire/ --New research directions are being explored to find therapies for hard to treat diseases. One exciting new approach is the use of autologous Adult Stem Cells. Multiple Sclerosis (MS) is one of the many notable diseasesadult stem cell therapycould potentially impact. Multiple Sclerosis (MS) is a disorder in which an individual's own immune system attacks the 'myelin sheath'. The myelin sheath serves to protect the nerve cells within the body's central nervous system (CNS). The damage caused by MS may result in many types of symptoms including: (Photo: http://photos.prnewswire.com/prnh/20121010/LA89802-INFO) Currently there is no cure for MS, but MS stem cell therapiesattempt to slow the disease's progression and limit symptoms. Since adult stem cells have the ability to differentiate into many different types of cells, such as those required for proper functioning and protection of nerve cells, the use of adult stem cells for MS therapy could be of substantial value. Adult stem cells can be isolated with relative ease from an individual's own 'adipose' (fat) tissue. As a result, adult stem cell therapy is not subject to the ethical or religious issues troubling embryonic methods. Encouragingly for MS treatment potential, scientific researchers have … Continue reading →

Kyodo / Reuters Kyoto University Professor Shinya Yamanaka (left) and John Gurdon of the Gurdon Institute in Cambridge, England, at a symposium on induced pluripotent stem cells in Tokyo in April 2008 In a testament to the revolutionary potential of the field of regenerative medicine, in which scientists are able to create and replace any cells that are at fault in disease, the Nobel Prize committee on Monday awarded the 2012 Nobel in Physiology or Medicine to two researchers whose discoveries have made such cellular alchemy possible. The prize went to John B. Gurdon of the University of Cambridge in England, who was among the first to clone an animal, a frog, in 1962, and to Shinya Yamanaka of Kyoto University in Japan who in 2006 discovered the four genes necessary to reprogram an adult cell back to an embryonic state. Sir John Gurdon, who is now a professor at an institute that bears his name, earned the ridicule of many colleagues back in the 1960s when he set out on a series of experiments to show that the development of cells could be reversed. At the time, biologists knew that all cells in an embryo had the potential to … Continue reading →

The Nobel Prize in Medicine or Physiology for 2012 was awarded jointly to British scientist John B. Gurdon and Japanese scientist Shinya Yamanaka for their work in stem cell research, the Karolinska Institute in Stockholm announced Monday. The announcement opens the prestigious award season for this year while the speculation over literature and peace prizes is rife. "These groundbreaking discoveries have completely changed our view of the development and specialization of cells," the Nobel Assembly at Sweden's Karolinska Institute said in a statement on its website. We now understand that the mature cell does not have to be confined forever to its specialized state. Textbooks have been rewritten and new research fields have been established. By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy," the statement said. Gurdon discovered in 1962 that the specialization of cells is reversible. Yamanaka discovered more than 40 years later in 2006 how the intact mature cells in mice could be reprogrammed to become immature stem cells. These groundbreaking discoveries have completely changed our view of the development and cellular specialization, the institute has said. Gurdon was born in 1933 in Dippenhall, the U.K, and … Continue reading →

British researcher John Gurdon and Shinya Yamanaka from Japan have shared the Nobel prize for medicine or physiology. The two pioneers of stem cell research were awarded the prize for transforming specialised cells into stem cells, which can become any other type of cell in the body. John Gurdon discovered in 1962 that the specialisation of cells is reversible. In a classic experiment, he replaced the immature cell nucleus in an egg cell of a frog with the nucleus from a mature intestinal cell. This modified egg cell developed into a normal tadpole. The DNA of the mature cell still had all the information needed to develop all cells in the frog. Shinya Yamanaka discovered more than 40 years later, in 2006, how intact mature cells in mice could be reprogrammed to become immature stem cells. Surprisingly, by introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, i.e. immature cells that are able to develop into all types of cells in the body. These groundbreaking discoveries have completely changed our view of the development and cellular specialisation. By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis … Continue reading →