Category Archives: Mesenchymal Stem Cells

Abstract Introduction Stem cell therapy has recently been introduced to treat patients with type 2 diabetes mellitus (T2DM). However, no data are available on the efficacy and safety of allogeneic Whartons Jelly-derived mesenchymal stem cell (WJ-MSC) transplantation in patients with T2DM. Here we performed a non-placebo controlled prospective phase I/II study to determine efficacy and safety of WJ-MSC transplantation in T2DM. Twenty-two patients with T2DM were enrolled and received WJ-MSC transplantation through one intravenous injection and one intrapancreatic endovascular injection (catheterization). They were followed up for 12months after transplantation. The primary endpoints were changes in the levels of glycated hemoglobin and C-peptide and the secondary endpoints included insulin dosage, fasting blood glucose (FBG), post-meal blood glucose (PBG), inflammatory markers and T lymphocyte counts. WJ-MSC transplantation significantly decreased the levels of glucose and glycated hemoglobin, improved C-peptide levels and beta cell function, and reduced markers of systemic inflammation and T lymphocyte counts. No major WJ-MSC transplantation-related adverse events occurred, but data suggest a temporary decrease in levels of C-peptide and beta cell function at one month after treatment, possibly related to intrapancreatic endovascular injection. Our data demonstrate that treatment with WJ-MSCs can improve metabolic control and beta cell function in patients … Continue reading →

Inside each of our hard, calcified teeth is a small population of living stem cells that can differentiate into many types of tissue. The origin of those stem cells has long been unknown, but scientists may now have a completely surprising answer: Cells of the nervous system can migrate into the middle of a tooth and actually turn back into stem cells. If verified, this could be a possible new source for stem cells. Teeth are connected to nerves, as anyone who's had the misfortune of a toothache would know. Igor Adameyko of the Karolinska Institute in Stockholm and his team were studying glial cells, which support and protect neurons, in mice. By fluorescently labeling these glial cells, they could track the fate of these cells over time. What they found was entirely surprising. Glial cells from nerves in the gums actually migrated into teeth, where they turned into mesenchymal stem cells and eventually into tooth cells. Stem cells differentiating into specific cells is to be expected, but glial cells turning into stem cells is the exact opposite of what we thought we knew. The study published in Nature is definitely exciting, but it will of course need to be … Continue reading →

Heal Interstitial Cystitis with Stem Cell Therapy via YouTube Capture. By: Minecraft madness and mayhem … Continue reading →

PUBLIC RELEASE DATE: 28-Jul-2014 Contact: Meng Zhao eic@nrren.org 86-138-049-98773 Neural Regeneration Research MicroRNAs (miRNAs) play an important regulatory role in the self-renewal and differentiation of stem cells. Dr. Defeng Zou and co-workers from the First Affiliated Hospital of China Medical University, China focuses on the effect of miRNA overexpression on the differentiation of bone marrow-derived mesenchymal stem cells into neurons. In the study released on the Neural Regeneration Research (Vol. 9, No. 12, 2014), researchers used GeneChip technology to analyze the expression of miRNAs in bone marrow-derived mesenchymal stem cells, neural stem cells and neurons. They constructed a lentiviral vector overexpressing miR-124 and transfected it into bone marrow-derived mesenchymal stem cells. Intracellular expression levels of the neuronal early markers -III tubulin and microtubule-associated protein-2 were significantly increased, and apoptosis was reduced in transfected cells. After miR-124-transfected bone marrow-derived mesenchymal stem cells were transplanted into the injured rat spinal cord, a large number of cells positive for the neuronal marker neurofilament-200 were observed in the transplanted region. The Basso-Beattie-Bresnahan locomotion scores showed that the motor function of the hind limb of rats with spinal cord injury was substantially improved. These results suggest that miR-124 plays an important role in the differentiation … Continue reading →

Published at Retail Investor 360: Monday, 28 July 2014 20:02 by Doctor Hung V. Tran, MD, MS Disclosure: I am long on MNKD. Due to its capacity to self-renew and give rise to cells of various lineage, mesenchymal stem cells (MSCs) have generated a great amount of enthusiasm over the past decade as a novel therapeutic paradigm for a variety of diseases. The leading, integrated stem cell company Osiris Therapeutics (NASDAQ:OSIR) thus indeed has captured and gained a significant impact in this unique market since infancy with its capabilities in groundbreaking research, development, manufacturing, marketing and distribution of stem cell products to treat unmet medical conditions in orthopedic, sport medicine and specifically wound care markets. Source: Stem Cell Giving the diabetes mellitus market is growing at a rapid rate globally; roughly 25 million or 8.3% of the U.S. population suffer from this condition. With its FDA approved super rapid acting insulin, Afrezza, that could mimic the actions of healthy pancreas, Mannkind Corporation (NASDAQ: MNKD) is already positioned it self to become the new leader in this huge insulin market. Diabetic complications such as diabetic foot ulceration, infection, and gangrene are significant complications and the leading causes of hospitalization in patients … Continue reading →

Kellie van Meurs, pictured with her husband Mark, died while undergoing stem cell treatment in Russia. Photo: Facebook Supporters of a Brisbane mother-of-two who died while undergoing a controversial stem cell treatment in Russia say it did not cause her death, nor have others been discouraged from seeking it. Kellie van Meurs suffered from a rare neurological disorder called stiff person syndrome, which causes progressive rigidity of the body and chronic pain. She travelled to Moscow in late June to undergo an autologous haematopoietic stem cell transplant (HSCT) under the care of Dr Denis Fedorenko from the National Pirogov Medical Surgical Centre. Kellie van Meurs, pictured with family and supporters, died while undergoing stem cell treatment in Russia. Photo: Facebook The transplant more commonly used for multiple sclerosis patients involves rebooting a patients immune system with their own stem cells after high-dose chemotherapy. Advertisement Ms van Meurs was Dr Fedorenkos first SPS patient, and her husband Mark said she died of a heart attack on July 19. I do know that Rosemary [Ms van Meurs' aunt and carer in Moscow] felt she received the best possible care, especially from Dr Fedorenko, he said. Given her level of constant pain and … Continue reading →

Details Published on Saturday, 26 July 2014 21:02 A study found that stem cells injected into mice helped shorten muscle repair time. Picture courtesy of Shutterstock.com NEW YORK: Research conducted on exercising mice at the University of Illinois at Urbana-Champaign could open new doors in the field of muscle repair using stem cells. Scientists injected stem cells prior to encouraging mice to perform exercises considered the rough equivalent of human lengthening contractions performed as part of resistance training. They found the time of muscle repair was shortened and they achieved considerable development of the mices muscles. We have an interest in understanding how muscle responds to exercise, and which cellular components contribute to the increase in repair and growth with exercise, says study author and University of Illinois kinesiology and community health professor Marni Boppart. Boppart says the research is important in treating atrophy and age-related degradation in both the structure and the function of muscles. But the primary goal of our lab really is to have some understanding of how we can rejuvenate the aged muscle to prevent the physical disability that occurs with age, and to increase quality of life in general as well, she continued. The types … Continue reading →

STEM CELL THERAPY SUPERNOVA We implant EMBRYONIC STEM CELLS from our STEM CELL BANK This is state-of-the-art ADVANTAGE for it eliminates the suffering and pain from liposuction(fat removal) or bone marrow extraction,... By: Leong Lau … Continue reading →

July 24, 2014, 10:29 p.m. A 60 MINUTES report on new multiple sclerosis stem cell therapy has thrown Wendouree mum Kathryn Johnston a potential lifeline. A 60 MINUTES report on new multiple sclerosis stem cell therapy has thrown Wendouree mum Kathryn Johnston a potential lifeline. Hopeful: Wendouree mum Kathryn Johnston is hoping new stem cell therapy treatment will help her be a more active mother to her daughter Dellah, 7. PICTURE: KATE HEALY Ms Johnston, who has had MS for 15 years, is hoping the treatment will help her be a more active mother to daughter Dellah, 7. I cant do a great deal with my daughter now but its also the unknown not knowing if Ill wake up one day and not be able to walk, Ms Johnston said. The 35-year-old emergency nurse hopes to travel to Russia in August next year for the treatment, which involves extracting her stem cells, freezing them while she undergoes a strong course of chemotherapy and then replacing them. It gets rid of any underlying MS and rebuilds the immune system from scratch. As a general rule, its been about 80 per cent effective. Ms Johnston first noticed her MS symptoms as an … Continue reading →

La Jolla, CA (PRWEB) July 23, 2014 StemGenex, the leading resource for adult adipose stem cell therapy in the US aimed at improving the lives of patients dealing with degenerative diseases today announced their newest clinical study for Parkinsons disease. StemGenex believes that a commitment to the safety and efficacy of stem cell therapy are paramount when providing care to patients with degenerative diseases. This clinical study makes stem cell therapy accessible to the millions of individuals currently living with Parkinsons disease. The protocol used in these stem cell treatments is unique to StemGenex, having the possibility of being more effective than other stem cell treatments currently available. StemGenex has developed a multiple administration protocol for patients suffering from Parkinsons disease which includes targeted methods of stem cell delivery. Among these methods is a novel approach for delivering stem cells past the blood brain barrier an issue most stem cell treatments have been challenged by. Principal Investigator Dr. Jeremiah McDole, Ph.D. stated, As is the case with most neurodegenerative conditions, there are few available drugs to treat Parkinsons disease. The handful of drugs that are available can only ameliorate symptoms and unfortunately, prolonged usage can create terrible side-effects. Further, these … Continue reading →