Category Archives: Mesenchymal Stem Cells

Jan. 14, 2014 Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, according to an international collaboration of researchers. Their finding sheds new light on the process that makes cancer a deadly disease. "The lethal part of cancer is its metastasis so understanding how metastasis occurs is critical," says senior study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the University of Michigan Comprehensive Cancer Center. "We have evidence that cancer stem cells are responsible for metastasis -- they are the seeds that mediate cancer's spread. Now we've discovered how the stem cells do this." First, on the outside of the tumor, a type of stem cell exists in a state called the epithelial-mesenchymal transition (EMT) state. These stem cells appear dormant but are very invasive and able to get into the bloodstream, where they travel to distant parts of the body. Once there, the stem cells transition to a second state that displays the opposite characteristics, called the mesenchymal-epithelial transition state (MET). These cells are capable of growing and making copies of themselves, producing new tumors. "You need both forms of cancer stem cells to … Continue reading →

Panama City, Panama (PRWEB) January 14, 2014 Translational Biosciences, a subsidiary of Medistem Panama has received the countys first clinical trial approval for the treatment of rheumatoid arthritis with human umbilical cord-derived mesenchymal stem cells (MSC) from the Comit Nacional de Biotica de la Investigacin Institutional Review Board (IRB). Rheumatoid Arthritis (RA) is an autoimmune disease in which the patients immune system generates cellular and antibody responses to various components of the joint such as type I collagen. As a result of this immune response, not only does joint destruction occur, but also other secondary complications such as pulmonary fibrosis, renal damage, and even heart damage. RA affects approximately 0.5-1% of the population in the United States. Mesenchymal stem cells harvested from donated human umbilical cords after normal, healthy births possess anti-inflammatory and immune modulatory properties that may relieve RA symptoms. Because they are immune privileged, the recipients immune system does not reject them. These properties make MSC interesting candidates for the treatment of rheumatoid arthritis and other autoimmune disorders. Each patient will receive five intravenous injections of umbilical cord stem cells over the course of 5 days. They will be assessed at 3 months and 12 month primarily for … Continue reading →

European researchers have announced a breakthrough in the development of artificial bone marrow which expands the ability of scientists to reproduce stem cells in the lab and could lead to increased availability of treatment for leukemia sufferers. One of the main treatments for the blood cancer is the injection of hematopoietic stem cells (HSCs). These HSCs can either be harvested from a compatible donor or cultivated from the patients own bone marrow in the lab. The greatest challenges in producing HSCs in the lab has been their limited longevity outside of the bone marrow environment. This problem may soon be circumvented with the creation of an artificial bone marrow by the Young Investigators Group for Stem Cell Material Interactions. Headed by Dr. Cornelia Lee-Thedieck the group consists of scientists from the KIT Institute of Functional Interfaces (IFG), the Max Planck Institute for Intelligent Systems, Stuttgart, and Tbingen University. The cultivation of HSCs with current methods is limited as they quickly change into mature blood cells in culture in a process known as differentiation. HSCs are capable of developing into one of 10 different cell types. These mature cells are short lived and are not capable of self-renewal. HSCs, however, can … Continue reading →

one year after stem cell therapy by Dr Harry Adelson for an arthritic ankle Jim discusses his outcome one year after stem cell therapy by Dr Harry Adelson for an arthritic ankle http://www.docereclinics.com. By: Harry Adelson … Continue reading →

Manassas, VA (PRWEB) January 09, 2014 ATCC is featuring specific cell-based solutions for screening at SLAS2014, the 3rd Annual Conference and Exhibition of the Society for Laboratory Automation and Screening. Meeting attendees visiting ATCC at booth #1348 will find helpful information on hTERT immortalized cell lines, human stem cells, cancer cell panels, and reagents that are particularly suited for screening and drug discovery research. ATCC, the premier global biological materials resource and standards organization, maintains the largest collection of cells lines characterized and authenticated for use by the research community. Cell-based screening programs, especially when automated, require a stable supply of cells for extended studies. To aid in this endeavor, ATCC currently maintains over 20 human telomerase reverse transcriptase (hTERT) immortalized cell lines of different types, including epithelial cells derived from various human tissues. These cell lines represent a breakthrough in cell biology research that combines the in vivo characteristics of primary cells with the ability to survive continuously in vitro. Translational screening using human derived stem cells are gathering attention at this years meeting. Interested scientists will find information on human induced pluripotent stem cells (iPSC) and mesenchymal stem cells (MSC) at the ATCC exhibit. These fully authenticated and … Continue reading →

PUBLIC RELEASE DATE: 6-Jan-2014 Contact: Daniel Kane dbkane@ucsd.edu 858-534-3262 University of California - San Diego With the help of biomimetic matrices, a research team led by bioengineers at the University of California, San Diego has discovered exactly how calcium phosphate can coax stem cells to become bone-building cells. This work is published in the Proceedings of the National Academy of Sciences the week of Jan. 6, 2014. UC San Diego Jacobs School of Engineering professor Shyni Varghese and colleagues have traced a surprising pathway from these biomaterials to bone formation. Their findings will help them refine the design of biomaterials that encourage stem cells to give rise to new bone. The researchers say their study may also point out new targets for treating bone defects and bone metabolic disorders such as major fractures and osteoporosis. The materials are built to mimic the body's own cellular niches, in which undifferentiated or "blank-slate" stem cells from bone marrow transform into specific bone-forming cells. "We knew for years that calcium phosphate-based materials promote osteogenic differentiation of stem cells, but none of us knew why," Varghese said. "As engineers, we want to build something that is reproducible and consistent," she explained, "so we need … Continue reading →

Regenocyte Adult Stem Cell Therapy-Neim Malo By: RegenocyteStemCells … Continue reading →

NEW YORK, Jan. 6, 2014 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue: Translational Regenerative Medicine: Market Prospects 2014-2024 http://www.reportlinker.com/p0595030/Translational-Regenerative-Medicine-Market-Prospects-2014-2024.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Blood_Supply,_Tissue_Banking_and_Transplantation Report Details Our new study shows you the commercial potential of regenerative treatments What does the future hold for regenerative medicine? Visiongain's brand new report shows you potential revenues to 2024, assessing data, trends, opportunities and prospects there. Our study lets you assess regenerative medicine: cell-based therapies that aim to restore function and regenerate diseased tissues. It lets you assess projected sales at world market, market segment, product and regional level to 2024. You will see financial results, interviews, trends, opportunities, and revenue predictions. In our investigation you also see qualitative analyses, news R&D and business developments. Our 240 page report provides 122 tables, charts, and graphs. Read the full transcripts of three exclusive expert opinion interviews from leading industry specialists informing your understanding and allowing you to assess prospects for investments and sales: - Dr. Alan Trounson - President, California Institute for Regenerative Medicine (CIRM) - Professor Francois Berthiaume - Associate Professor of Biomedical Engineering, Rutgers University, New Jersey - Dr. William Dolphin - CEO, Avita Medical You will find prospects for … Continue reading →

Regenocyte Adult Stem Cell Therapy - LouAnn Rest Regenocyte Adult Stem Cell Therapy an interview with patient LouAnn Rest. By: RegenocyteStemCells … Continue reading →

Published on November 7, 2013. For those of us effected by osteoarthritis we know the impact it can have on quality of life. The research surrounding an effective treatment for osteoarthritis has yet to find an approved pharmacological intervention, biologic therapy or procedure that prevents the progressive destruction of the osteoarthritis joint. Stem cell injections for osteoarthritis(your own stem cells) can help maintenance healthy tissues by acting as repair cells or to reduce inflammation. The injection of Mesenchymal stem cells has produced promising outcomes in preclinical models of joint disease. (1) In dealing with knee osteoarthritis, research notes that conventional treatments for osteoarthritis have demonstrated only modest clinical benefits and without cartilage repair. However, what research is also confirming is that stem cell therapies have shown encouraging results. They have confirmed feasibility and safety and strong indications of clinical efficacy were identified. Patients exhibited rapid and progressive improvement. . . Stem Cell therapy may be a valid alternative treatment for chronic knee osteoarthritis. The intervention is simple, does not require hospitalization or surgery, provides pain relief, and significantly improves cartilage quality. (2) If you suffer from crippling, degenerative joint disease stem cell therapy may be the breakthrough treatment you are … Continue reading →