Category Archives: Mesenchymal Stem Cells

Mesenchymal stem cells/marrow stromal cells (MSCs) present a promising tool for cell therapy, and are currently being tested in US FDA-approved clinical trials for myocardial infarction, stroke, meniscus injury, limb ischemia, graft-versus-host disease and autoimmune disorders. They have been extensively tested and proven effective in preclinical studies for these and many other disorders. There is currently a great deal of interest in the use of MSCs to treat neurodegenerative diseases, in particular for those that are fatal and difficult to treat, such as Huntington's disease and amyotrophic lateral sclerosis. Proposed regenerative approaches to neurological diseases using MSCs include cell therapies in which cells are delivered via intracerebral or intrathecal injection. Upon transplantation into the brain, MSCs promote endogenous neuronal growth, decrease apoptosis, reduce levels of free radicals, encourage synaptic connection from damaged neurons and regulate inflammation, primarily through paracrine actions. MSCs transplanted into the brain have been demonstrated to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons. Therapies will capitalize on the innate trophic support from MSCs or on augmented growth factor support, such as delivering brain-derived neurotrophic factor or glial-derived neurotrophic factor into the brain to support injured neurons, using genetically engineered … Continue reading →

stem cell therapy, stem cell treatment, stem cell transplants, stem cell facelift, stem cell arthritis, stem cell and autism, stem cell and multiple sclerosis, arthritis pain and stem cell, knee pain and stem cell, stem cell treatment autoimmune, Mesenchymal Stem Cells Therapy, Platelet Rich Plasma (PRP) Injections CELL THERAPY FLORIDA with newer techniques and equipment, can easily obtain from a patient, activate, and transplant adult stem cells back to the patient by a simple office procedure done within the same day as part of the Stem Cell USA Program. The process of actively extracting, concentrating and administering these stem cells has been shown in clinical trials to have beneficial effects in degenerative and other conditions. Once injected, stem cells follow inflammatory signals from damaged tissues and have multiple ways of repairing these damaged areas. Studies have also shown that these are capable of homing to and secrete proteins and peptides that stimulate healing of damaged tissue. Adult stem cells isolated from fat tissue have the ability to become different cell types (i.e. nerve cells, liver cells, heart cells, and cartilage cells). 1. Harvesting: CELLMedix can collect adult stem cells from multiple sites of the body. For our Stem Cell USA … Continue reading →

The Centeno-Schultz Clinic is a research-based medical practice founded by Christopher J. Centeno,M.D., and John R. Schultz, M.D. . The Regenexx procedures have been studied extensively for several years and we maintain what we believe to be the worlds largest human mesenchymal stem cell re-implantation database for orthopedic purposes. The original Regenexx-C procedure was first used as part of an IRB supervised clinical trial from 2005-2007. During this time our medical practice invested hundreds of thousands of dollars in providinginvestigationalcare, with all patientsreceivingbefore and after research-grade MRIs. For more information on how physicians innovate versus how FDA/drugcompaniesdiscover new drugs, see this link. By late 2007, once the physicians were satisfied that the procedure was working and that the complications were less than existing surgical care, the clinic began treating patients. Since that time the clinic has published many medical research papers listed in the U.S. Library of Medicine (see this link for an incomplete list). Every patient treated by us is entered into a treatment registry and will be contacted atvarioustime points regarding the outcome of the procedure, any complications, etc As a result, we have extensive experience in what works and what doesnt work. In addition, based onourpublished complications … Continue reading →

Mesenchymal (stromal) stem cells give rise to a variety of cell types, including bone cells (osteocytes), cartilage cells (chondrocytes), fat cells (adipocytes), pancreatic islet cells and connective tissue cells such as those found in tendons. Mesenchymal stem cells can be found in umbilical cord blood, fat, muscleand the pulp of baby teeth. They are referred to as multipotent cells because they can develop into multiple tissues, but they do not have the capacity to reconstitute an entire organ. An extremely rich source of mesenchymal stem cells is the developing tooth bud of the mandibular (lower) third molar, or wisdom tooth. While considered multipotent, these stem cells may prove to be pluripotent, capable of generating all tissue types. The stem cells found in developing third molars eventually form enamel, dentin, blood vessels, dental pulp, nervous tissue and a minimum of 29 different unique tissues and organs. Because of extreme ease in collection at 810 years of age, they will probably constitute a major source for personal banking, research and multiple therapies. Adipose (fat) tissue is one of the richest sources of mesenchymal stem cells. There are 500 times more mesenchymal stem cells in 1 gram of fat than there are in … Continue reading →

Mesenchyme, also called mesenchymal connective tissue, is a type of undifferentiated loose connective tissue that is derived mostly from mesoderm, although some is derived from other germ layers; e.g. neural crest cells and thus originates from the ectoderm. Most embryologists use the term "mesenchyme" only for those cells that develop from the mesoderm.[citation needed] The term mesenchyme essentially refers to the morphology of embryonic cells, however, they do persist as stem cells into adulthood. Mesenchymal cells are able to develop into the tissues of the lymphatic and circulatory systems, as well as connective tissues throughout the body, such as bone and cartilage. A sarcoma is a cancer of mesenchymal cells.[1][2] Mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibrils and unspecialized cells.[3] Mesenchymal cells can migrate easily, in contrast to epithelial cells, which lack mobility and are organized into closely adherent sheets, are polygonal in shape, and are polarized in an apical-basal orientation. See the original post here: Mesenchyme - Wikipedia, the free encyclopedia … Continue reading →

Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types,[1] including: osteoblasts (bone cells),[2]chondrocytes (cartilage cells),[3] and adipocytes (fat cells). This phenomenon has been documented in specific cells and tissues in living animals and their counterparts growing in tissue culture. While the terms Mesenchymal Stem Cell and Marrow Stromal Cell have been used interchangeably, neither term is sufficiently descriptive as discussed below: The youngest, most primitive MSCs can be obtained from the umbilical cord tissue, namely Wharton's jelly and the umbilical cord blood. However the MSCs are found in much higher concentration in the Whartons jelly compared to the umbilical cord blood, which is a rich source of hematopoietic stem cells. The umbilical cord is easily obtained after the birth of the newborn, is normally thrown away and poses no risk for collection. The umbilical cord MSCs have more primitive properties than other adult MSCs obtained later in life, which might make them a useful source of MSCs for clinical applications. An extremely rich source for mesenchymal stem cells is the developing tooth bud of the mandibular third molar. While considered multipotent, they may prove to be pluripotent. The stem cells eventually … Continue reading →

BrainStorm Cell Therapeutics - Company Presentation Presented by: Adrian Harel, Ph.D., Director of R D BrainStorm is a biotechnology company developing innovative adult stem cell therapies derived from autolog... By: Alliance for Regenerative Medicine … Continue reading →

By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Stem Cell Research is now available. According to news reporting from Chongqing, People's Republic of China, by NewsRx journalists, research stated, "The purpose of this study was to investigate the influences of nanoscale wear particles derived from titanium/titanium alloy-based implants on integration of bone. Here we report the potential impact of titanium oxide (TiO2) nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells (MSC) from the cellular level to the molecular level in the Wistar rat." The news correspondents obtained a quote from the research from Chongqing University, "A series of TiO2 nanoparticles (14 nm, 108 nm, and 196 nm) were synthesized and characterized by scanning electron microscopy and transmission electron microscopy, respectively. The TiO2 nanoparticles had negative effects on cell viability, proliferation, and the cell cycle of MSC in a dose-dependent and size-dependent manner. Confocal laser scanning microscopy was used to investigate the effects of particle internalization on adhesion, spreading, and morphology of MSC. The integrity of the cell membrane, cytoskeleton, and vinculin of MSC were negatively influenced by large TiO2 nanoparticles. The Transwell migration assay and a wound healing model suggested … Continue reading →

Washington, Oct. 21 : Researchers have identified a protein that is expressed by human bone marrow stem cells that helps guide and stimulate the formation of blood vessels. Their findings, which could help improve the vascularization of engineered tissues, were reported online on October 12 in the Journal of Molecular and Cellular Cardiology. Lead author Dr. Jalees Rehman, associate professor of cardiology and pharmacology at the UIC College of Medicine, said that some stem cells actually have multiple jobs, for example, stem cells in the bone marrow differentiate into bone or cartilage, but also have a secondary role in helping to support other cells in the bone marrow. Rehman and his team, who are developing engineered tissues for use in cardiac patients, observed that certain stem cells in bone marrow, called mesenchymal stem cells, seemed crucial for organizing other cells into functional blood vessels. The researchers demonstrated that when they mixed mesenchymal stem cells from human bone marrow with the endothelial cells that line blood vessels, the stem cells elongated to form scaffolds and the endothelial cells organized around them to form tubes. Rehman said that without the stem cells, the endothelial cells just sat there. When the cell mixtures … Continue reading →

New Technology Investment in Age-Old Question: Regenerative Medicine October 1, 2013 (www.investorideas.com newswire) Regenerative medicine is a field involving the study of stem cells to regenerate or regrow cells and even entire body parts in humans, reestablishing normal function. Successes in regenerative medicine could help the entire medical field advance as previously chronic and incurable conditions may be reversible. Some estimates claim that as many as 1 in 3 Americans would be helped by regenerative medicine therapies. Stem cells function as "master cells," which have the ability to become any other type of cell. Natural stem cells can be found in human cord blood and embryos. Stem cells can also be created through a "reprogramming" process, using blood and skin cells to create induced pluripotent stem cells (iPS). Recently, scientists at the Spanish National Cancer Research Center in Madrid were able to replicate human stem cells in mice, opening a new avenue for regenerative medicine. These cells may possess more plasticity and may be better able to differentiate into many more types of adult human cells than traditional iPS cells. According to a recent article in Forbes, regenerative medicine could take 20 to 25 years to truly come to fruition. … Continue reading →