Category Archives: Mesenchymal Stem Cells

Abstract Mesenchymal stem cells (MSCs) have recently made significant progress with multiple clinical trials targeting modulation of immune responses, regeneration of bone, cartilage, myocardia, and diseases like Metachromatic leukodystrophy and Hurler syndrome. On the other hand, the use of human embryonic and induced pluripotent stem cells (hPSCs) in clinical trials is rather limited mainly due to safety issues. Only two clinical trials, retinal pigment epithelial transplantation and treatment of spinal cord injury were reported. Cell doses per treatment can range between 50,000 and 6billion cells. The current 2-dimensional tissue culture platform can be used when low cell doses are needed and it becomes impractical when doses above 50million are needed. This demand for future cell therapy has reinvigorated interests in the use of the microcarrier platform for generating stem cells in a scalable 3-dimensional manner. Microcarriers developed for culturing adherent cell lines in suspension have been used mainly in vaccine production and research purposes. Since MSCs grow as monolayers similar to conventional adherent cell lines, adapting MSCs to a microcarrier based expansion platform has been progressing rapidly. On the other hand, establishing a robust microcarrier platform for hPSCs is more challenging as these cells grow in multilayer colonies on extracellular … Continue reading →

(Before It's News) Order report by calling ReportsnReports.com at +1 888 391 5441 OR send an email on sales@reportsandreports.com with (Mesenchymal Stem Cells) in subject line and your contact details. This global strategic report is produced for: It is designed to increase your efficiency and effectiveness in: Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, beta-pancreatic islets cells, and potentially, neuronal cells. MSCs are of intense therapeutic interest because they represent a population of cells with the potential to treat a wide range of acute and degenerative diseases. Complete report is spread across 171 pages is available @ http://www.reportsnreports.com/reports/10598-mesenchymal-stem-cells-advances-applications.html Interest in therapeutic applications of human MSCs arises from their diverse ability to differentiate into a range of cell types, as well as from their ability to migrate to sites of tissue injury/inflammation or tumor growth. These localization properties present a promising strategy for targeted introduction of therapeutic agents through MSC gene therapy. In addition, MSCs possess strong immunosuppressive properties that medical researchers are exploiting for both autologous as well as heterologous therapies. Clinical Progress with MSCs As mentioned, mesenchymal stem cells (MSCs) have inspired a lot … Continue reading →

Abstract Introduction Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost with successive passages. Hence, pluripotent derived MSCs (PD-MSCs) arise as a suitable alternative for MSC production. Nevertheless, at present, PD-MSC derivation protocols are either expensive or not suitable for clinical purposes. In this work we present a therapy-grade, inexpensive and simple protocol to derive MSCs from pluripotent stem cells (PSCs) based on the use of platelet lysate (PL) as medium supplement. We showed that the PD-MSCPL expressed multiple MSC markers, including CD90, CD73, CD105, CD166, and CD271, among others. These cells also show multilineage differentiation ability and immunomodulatory effects on pre-stimulated lymphocytes. Thorough characterization of these cells showed that a PD-MSCPL resembles an umbilical cord (UC) MSC and differs from a PSC in surface marker and extracellular matrix proteins and integrin expression. Moreover, the OCT-4 promoter is re-methylated with mesenchymal differentiation comparable with the methylation levels of UC-MSCs and fibroblasts. Lastly, the use of PL-supplemented medium generates significantly more MSCs than the use of fetal bovine serum. This protocol can be used to generate a large amount … Continue reading →

Summary Top of page Summary Introduction Extracellular vesicles produced by stem cells What we have learned from mature liver cell transplantation in humans? MSCs in human clinical applications Disclosure of Conflict of Interests References Hemophilia remains a non-curative disease, and patients are constrained to undergo repeated injections of clotting factors. In contrast, the sustained production of endogenous factors VIII (FVIII) or IX (FIX) by the patient's own cells could represent a curative treatment. Gene therapy has thus provided new hope for these patients. However, the issues surrounding the durability of expression and immune responses against gene transfer vectors remain. Cell therapy, involving stem cells expanded invitro, can provide de novo protein synthesis and, if implanted successfully, could induce a steady-state production of low quantities of factors, which may keep the patient above the level required to prevent spontaneous bleeding. Liver-derived stem cells are already being assessed in clinical trials for inborn errors of metabolism and, in view of their capacity to produce FVIII and FIX in cell culture, they are now also being considered for clinical application in hemophilia patients. Hemophilia A is the most common severe inherited bleeding disorder, affecting 1 in 5000 male births. This pathology exhibits different … Continue reading →

Understand and profit from the mesenchymal stem cell (MSC) product market the fastest growing area of stem cell research. Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, beta-pancreatic islets cells, and potentially, neuronal cells. MSCs are of intense therapeutic interest because they represent a population of cells with the potential to treat a wide range of acute and degenerative diseases. To Browse a Full Report with TOC: http://www.researchmoz.us/mesenchymal-stem-cells-advances-and-applications-2013-report.html MSCs are advantageous over other stem cells types for a variety of reasons: they avoid the ethical issues that surround embryonic stem cell research, and repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogenic transplantation. MSCs reduce both the risks of rejection and complications of transplantation. Recently, there have been advances in the use of autologous mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, bone fractures, and more. Trend analysis of grant activity, scientific publication rates, and patent applications trends reveal that global research activity involving mesenchymal stem cells (MSCs) increased 112% from 2009 to 2010, and 116% from 2010 to 2011. Of most interest is that … Continue reading →

Mesenchymal stem cells are the adult stem cells. Mesenchymal stem cells are of various types such as monocytes, adipocytes, osteocytes and chondrocytes. Mesenchymal stem cells main function is to replace or repair damage tissue. In addition, mesenchymal stem cells have high potential for tissue repair. Mesenchymal stem cells are isolated from other tissues such as fallopian tube, cord blood, fetal liver, peripheral blood and fetal lung. Mesenchymal stem cells are renewable source to substitute tissue and cells to treat disabilities and diseases. North America dominates the global market for mesenchymal stem cell due to large number of aging population and increasing incidence of cancers. Asia is expected to show high growth rates in the next five years in the global mesenchymal stem cell market. China and India are expected to be the fastest growing mesenchymal stem cell markets in Asia-Pacific region. Some of the key driving forces for mesenchymal stem cell market in emerging countries are large pool of patients and rising government funding and support. Buy Full Mesenchymal Stem Cells MarketReport:http://www.persistencemarketresearch.com/market-research/mesenchymal-stem-cells-market.asp In recent times there is increased use of mesenchymal stem cell due to increasing aging population. Rising incidence of chronic diseases, regulatory and government support and increasing investment … Continue reading →

Home > Stem Cell Therapy Call us for more information 561-368-1880 Source: Research by Tim Friend and Dan Vergano, USA TODAY By Frank Pompa and Julie Snider, USA TODAY Although the general public considers stem cell therapy an innovative, cutting-edge treatment, the fact is that this kind of therapy already has a lengthy history. In the past, however, stem cells were difficult and very expensive to obtain. Luckily, the advent of improved equipment and techniques has meant that stem cells can now be acquired through a simple procedure. Stem cells can be characterized as the bodys repairmen. The most common type is the hematopoietic stem cell (HSC-CD 34+). The old thinking was that the hematopoietic stem cells were not that important. We now know that these are the cells that are the true drivers of tissue regeneration. The good news about these cells is that their numbers do not diminish with age. The other type of stem cell associated with tissue healing is the mesenchymal stem cell (MSC), which usually travels to injured areas of the body via the bloodstream. The mesenchymal stem cell is still a very important stem cell but not as important as it once was. It … Continue reading →

You may also like.... Biomedical Engineering Student With CF Offers Perspective On How Regenerative Medicine Could Someday Treat the Disease Regenerative Medicine, Stem Cells Poised To Impact Development of CF Treatment CF Part of New $10 Million Rare & Neglected Diseases Research Grant at Notre Dame My last two articles have highlighted how Embryonic Stem Cells (ESCs), Induced Pluripotent Stem Cells (iPSCs), and Gestational Stem Cells have shaped regenerative medicine research for patients with cystic fibrosis (CF). In order to further delve into the function of stem cells, various approaches must be taken to uncover their therapeutic application. While the notion of stem cells may evoke an image of organ growth and regeneration, stem cells uniqueabilities span beyond repairing damaged tissue. Inflammation in lung diseases plays a pivotal role in the pathogenesis within the airway, and can lead to a greater frequency of pulmonary exacerbation. Unfortunately, diseases like cystic fibrosis demonstrate a more intense inflammatory response than other non-CF inflammatory diseases. There are several medication-based approaches aimed atconfronting this damaging inflammation, but another suitable method may be in our future. Mesenchymal Stem Cells (MSCs) are a type of stem cell found in a great number of tissues in the body. … Continue reading →

Abstract Background: The relationship between biological tissue healing following knee injury or surgery and long-term clinical outcome has come to the forefront of sports medicine practice. This has led many knee surgeons to incorporate biologically mediated healing factors into the management of knee injuries. In particular, the clinical use of mesenchymal stem cells has opened new horizons. Relevant studies were identified through a search of PubMed from January 2000 to April 2011, combining the term mesenchymal stem cells with articular cartilage, anterior cruciate ligament, and meniscus. Relevant citations from the reference lists of selected studies were also reviewed. Knee injury treatment with mesenchymal stem cells shows potential. Most reports represent animal model studies; few advances have been translated to human clinical applications. Mesenchymal stem cell use to promote healing following knee injury is likely to increase. There are scientific methodological concerns and ethical and legal issues regarding mesenchymal stem cell use for treating knee injuries. Keywords: biological tissue healing, cell-based therapy, cartilage repair Many patients who have sustained knee injuries desire treatment options that will enable them to continue sports participation. Over the past several years, the sports medicine community has seen an increase in the use of biological agents, … Continue reading →

The body has a variety of stem and progenitor cells that can morph into regular every-day cells. Most have a restricted repertoire. It seems, though, that mesenchymal cells can become a large variety of tissue types. This has great importance for replacement and repair of damaged organs and joints. Some of our cells are permanent: neurons and muscle being good examples, and some renew, like skin, and the intestines. The ones that renew, wear out. To make sure the new cells are fresh and whole, thay are made from stem cells or progenitor cells. Such cells are usually protected. Read all about stem cells here. The potency of a stem cell refers to its ability to generate other sorts of cells. The most potent is the fertilized egg. It, quite clearly, can generate every possible cell in our body. It is called toti-potent. None of the stem cells in an adult are that powerful. At least in vertebrates: . crustaceans stem cells are more stemmylobsters can regenerate all sorts of thingsclaws, eyes, etc. But for humans, the stem cells are limited, some very much so. The ones that generate intestines, for instance, can generate only the four types of cells … Continue reading →