Category Archives: Mesenchymal Stem Cells

A team of scientists has been able to engineer stable and functional blood vessels in mice using induced pluripotent stem (iPS) cells taken from humans. The blood vessels lasted for 280 days in the brain of the mice. The scientists are from Massachusetts General Hospital, Boston, and Harvard Stem Institute, Harvard University. The skin cells of healthy people and those with Type I diabetes were used to produce iPS cell lines, and, in turn, the blood vessels. The results of the study are published online on July 16 in the Proceedings of the National Academy of Sciences (PNAS) journal. This work is proof of concept demonstration that vascular precursor cells endothelial precursor cells and mesenchymal precursor cells from iPS cells can be used to engineer blood vessels. While endothelial cells form the inner lining of blood vessels, mesenchymal cells provide structural stability. 3 specific markers The method of deriving these two cells from iPS cells was by using three specific markers. The way we did it enabled us to engineer blood vessels in vivo [inside the mice] using sophisticated microscopy and mouse models, said Dr. Rekha Samuel, Professor of Pathology at the Centre for Stem Cell Research, CMC, Vellore, Tamil … Continue reading →

July 15, 2013 Massachusetts General Hospital (MGH) researchers have used vascular precursor cells derived from human induced pluripotent stem cells (iPSCs) to generate, in an animal model, functional blood vessels that lasted as long as nine months. In their report being published in PNAS Early Edition, the investigators describe using iPSCs -- reprogrammed adult cells that have many of the characteristics of embryonic stem cells -- from both healthy adults and from individuals with type 1 diabetes to generate blood vessels on the outer surface of the brain or under the skin of mice. "The discovery of ways to bring mature cells back to a 'stem-like' state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains," says Rakesh Jain, PhD, director of the Steele Laboratory for Tumor Biology at MGH and co-senior author of the study. "Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them to create networks of engineered blood vessels in living mice." The ability to regenerate or repair blood vessels could make a crucial difference … Continue reading →

Javascript is currently disabled in your web browser. For full site functionality, it is necessary to enable Javascript. In order to enable it, please see these instructions. 50 minutes ago Magnetic iron oxide particles could be used to help doctors direct stem cells to particular parts of the body. Here, a bar magnet was applied to the tail during injection. Otherwise most of the cells (labeled with a fluorescent dye) end up in the liver and lungs. Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease. By feeding stem cells tiny particles made of iron oxide, scientists at Emory and Georgia Tech can use magnets to attract the cells to a particular location in the body after intravenous injection. The results are published online in the journal Small and will appear in an upcoming issue. The paper was a result of collaboration between the laboratories of W. Robert Taylor, MD, PhD, and Gang Bao, PhD. Taylor is professor of medicine and biomedical engineering and director of the Division of Cardiology at Emory University School of Medicine. Bao is professor in the Wallace H. Coulter Department of Biomedical Engineering … Continue reading →

redOrbit Staff & Wire Reports Your Universe Online Massachusetts General Hospital (MGH) researchers have managed to create long-lasting blood vessels from reprogrammed human induced pluripotent stem cells (iPSCs), This groundbreaking research is published in the latest issue of the Proceedings of the National Academy of Sciences (PNAS) Early Edition. Using vascular precursor cells derived from iPSCs, reprogrammed adult cells that have several of the same characteristics of embryonic stem cells, the scientists were able to create functional blood vessels in an animal model that lasted up to nine months. In their study, the authors describe how they used cells from both healthy adults and those with type 1 diabetes to generate blood vessels under the skin or on the brains outer surface in mice. The discovery of ways to bring mature cells back to a stem-like state that can differentiate into many different types of tissue has brought enormous potential to the field of cell-based regenerative medicine, but the challenge of deriving functional cells from these iPSCs still remains, said co-author Rakesh Jain, director of the MGH Steele Laboratory for Tumor Biology. Our team has developed an efficient method to generate vascular precursor cells from human iPSCs and used them … Continue reading →

Public release date: 16-Jul-2013 [ | E-mail | Share ] Contact: Quinn Eastman qeastma@emory.edu 404-727-7829 Emory Health Sciences Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease. By feeding stem cells tiny particles made of iron oxide, scientists at Emory and Georgia Tech can use magnets to attract the cells to a particular location in the body after intravenous injection. The results are published online in the journal Small and will appear in an upcoming issue. The paper was a result of collaboration between the laboratories of W. Robert Taylor, MD, PhD, and Gang Bao, PhD. Taylor is professor of medicine and biomedical engineering and director of the Division of Cardiology at Emory University School of Medicine. Bao is professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. Co-first authors of the paper are postdoctoral fellows Natalia Landazuri, PhD, and Sheng Tong, PhD. Landazuri is now at the Karolinska Institute in Sweden. The type of cells used in the study, mesenchymal stem cells, are not embryonic stem cells. Mesenchymal stem cells can be readily obtained from adult tissues such as bone … Continue reading →

stem cell therapy for Sports injuries. Videos is about the Stem Cell Treatment provided to various athletes and sports persons. Dr. Purita had provided treatment for the knee, elbow, shoulder, wri... By: Stem Md … Continue reading →

July 12, 2013 A new, noninvasive technique for tracking stem cells after transplantation -- developed by a cross-disciplinary team of radiologists, chemists, statisticians and materials scientists at the Stanford University School of Medicine -- could help surgeons determine whether a procedure to repair injured or worn-out knees is successful. The technique, described in a study to be published online July 12 in Radiology, relies on an imaging agent already approved by the U.S. Food and Drug Administration for an entirely different purpose: anemia treatment. Although this study used rodents, the approach is likely to be adapted for use in humans this fall as part of a clinical trial in which mesenchymal stem cells will be delivered to the site of patients' knee injuries. Mesenchymal stem cells are capable of differentiating into bone and cartilage, as well as muscle, fat and tendon, but not into the other cell types that populate the body. Every year, arthritis accounts for 44 million outpatient visits and 700,000 knee-replacement procedures. But the early repair of cartilage defects in young patients may prevent further deterioration of the joint and the need for knee replacement later in life, said the study's senior author, Heike Daldrup-Link, MD, PhD, … Continue reading →

Habib Torfi and stem cell therapy at Invitrx Therapeutics Stem Cell Therapy. By: Habib Torfi … Continue reading →

Manila, Philippines -- If she would have her way, Dr. Marita V.T. Reyes, Co-Chairperson of the Philippine Health Research Ethics Board (PHREB), yesterday said she would put a stop to the medical procedure of stem cell therapy. Reyes delivered a paper yesterday on the topic, "Ethical Consideration In Stem Cell-based Therapy and Research-Poor Countries," on the last day of the 35th Annual Scientific Meeting of the Department of Science and Technology-National Academy of Science and Technology (DOST-NAST) at the historic landmark Manila Hotel. Reyes acknowledged that there is a "standard" stem cell therapy treatment involving "hematopoietic disorders," such as "leukemia and lymphomas," through "bone marrow or cord blood transplant." She, however, emphasized that this cannot be said yet in the cases of diseases of the heart, eyes, diabetes, stroke, spinal cord injury, Parkinson's, Alzheimer's, Lou Gehrig's (ALS), multiple sclerosis, cancer, and cartilage repair. Stem cell therapy for these diseases, she stressed, should be stopped. "If I have the power, I will say, 'stop this in the meantime, until the Food and Drug Administration (FDA) has come up with a quality assurance. Until the FDA is able to say that what you say is there, is there, we have no way … Continue reading →

Miami, Florida (PRWEB) July 12, 2013 Jose Cirino aligns himself with 30+ leading physicians in Miami, Florida to provide a series of educational seminars on the medical benefits of umbilical cord blood stem cell banking. Cirino has leveraged more than a decade of experience in the biotech industry and is a founding member of GeneCell International, Miamis preferred cord blood bank. As Director of Operations, he has expanded the company as well as the educational awareness in the field of adult stem cells worldwide. As the minority birth population continues to increase in Miami Florida, the gateway to international countries, Cirino feels it is essential the community is aware of the full potential of this benefit. Umbilical cord blood preservation is a process by which blood is collected from the umbilical cord of a newborn baby and is stored cryogenically in a specially-designated bank. According to the National Marrow Donor Program, cord blood contains cells that can be transfused to a patient to treat various diseases, including lymphoma and leukemia. Currently, there are approximately 80 treatable diseases and the list of illnesses continues to grow. Cord blood is rich in stem cells and because certain immune cells found in the … Continue reading →