Category Archives: Mesenchymal Stem Cells

The Science of Mesenchymal Stem Cells and Regenerative Medicine - Arnold Caplan PhD (Part 4) In part 4, Prof. Caplan talks about isolating mesenchymal stem cells from bone marrow using specialized; calf serum choosing different assays to prove multip... By: http://www.cellmedicine.com … Continue reading →

The Science of Mesenchymal Stem Cells and Regenerative Medicine - Arnold Caplan PhD (Part 3) In Part 3, Dr. Caplan discusses the science behind mesenchymal stem cells: sources of mesenchymal stem cells (MSCs), the fact that all MSCs are pericytes so ... By: http://www.cellmedicine.com … Continue reading →

apceth's first innovative cellular anti-cancer drug based on modified mesenchymal stem cells enters Phase I / II of clinical testing multicenter trial will start in Munich in Q2 2013 already broad international interest from industry and academia Munich Germany /B3C newswire/ - As the first biopharmaceutical company worldwide, apceth GmbH & Co. KG with its headquarters and manufacturing sites in Munich and Ottobrunn (near Munich) has received approval to conduct a clinical cancer trial with its genetically modified, adult mesenchymal stem cells. This is an entirely new approach for the treatment of advanced types of cancer for which there is currently no effective treatment available. The multicenter, open-label trial will recruit patients suffering from advanced adenocarcinomas of the gastrointestinal tract. This innovative therapy is based on mesenchymal stem cells harvested from the patient's own (autologous) bone marrow, which are processed, genetically modified and re-infused into the patient. The stem cells thus modified specifically target the tumor and the cytotoxic gene product is selectively activated at the site of the tumor or its metastases to increase local efficacy and to reduce systemic toxicity, one of the main problems of systemic chemotherapy. This unique principle is also applicable to other cancer types. … Continue reading →

Regenerative medicines hold incredible potential for new, more potent therapeutics to arrive in the future for a broad spectrum of diseases and conditions. As the industry in general is growing, more possibilities are emerging seemingly on a daily basis as research uncovers new ways to use stem cells to potentially combat deadly diseases like cancer where many patients have little to no hope with todays standards of care. A recent blog post on the website of American CryoStem, Corp. (OTCQB:CRYO - News) provides some clear information on the MGMT gene and its role in stunting the effectiveness of treating patients with brain cancer, a disease that kills nearly 14,000 people annually. According to the article, research has shown the powerful role that bone marrow stem cells can play as a combination therapy to increase the efficacy and lower toxicity in MGMT-positive brain cancer patients. However, collecting stem cells from bone marrow is a costly and highly invasive process. New research is outlining the potency of mesenchymal stem cells that are derived from the patients own adipose (fat) tissue that can potentially play a major role in new brain cancer treatments. Doctors arent sure why at this point, but mesenchymal stem … Continue reading →

June 13, 2013 A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. The important role of a specific microRNA transferred from stem cells to brain cells via the exosomes to enhance functional recovery after a stroke was shown in lab rats. This study provides fundamental new insight into how stem cells affect injured tissue and also offers hope for developing novel treatments for stroke and neurological diseases, the leading cause of long-term disability in adult humans. The study is being published in the journal Stem Cells. Although most stroke victims recover some ability to voluntarily use their hands and other body parts, nearly half are left with weakness on one side of their body, while a substantial number are permanently disabled. Currently no treatment exists for improving or restoring this lost motor function in stroke patients, mainly because of mysteries about how the brain and nerves repair themselves. "This study may have solved one of those mysteries by showing how certain stem cells play … Continue reading →

Public release date: 13-Jun-2013 [ | E-mail | Share ] Contact: Dwight Angell dwight.angell@hfhs.org 313-850-3471 Henry Ford Health System DETROIT A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. The important role of a specific microRNA transferred from stem cells to brain cells via the exosomes to enhance functional recovery after a stroke was shown in lab rats. This study provides fundamental new insight into how stem cells affect injured tissue and also offers hope for developing novel treatments for stroke and neurological diseases, the leading cause of long-term disability in adult humans. The study, to be published in the journal Stem Cells, is available at http://www.ncbi.nlm.nih.gov/pubmed/23630198. Although most stroke victims recover some ability to voluntarily use their hands and other body parts, nearly half are left with weakness on one side of their body, while a substantial number are permanently disabled. Currently no treatment exists for improving or restoring this lost motor function in stroke patients, mainly because of mysteries about how the … Continue reading →

Public release date: 13-Jun-2013 [ | E-mail | Share ] Contact: Darrell E. Ward Darrell.Ward@osumc.edu 614-293-3737 Ohio State University Medical Center COLUMBUS, Ohio A study led by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) has identified an abnormal metabolic pathway that drives cancer-cell growth in a particular glioblastoma subtype. The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer. The physician scientists sought to identify glioblastoma subtype-specific cancer stem cells. Genetic analyses have shown that high-grade gliomas can be divided into four subtypes: proneural, neural, classic and mesenchymal. This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype. The findings, published recently in the Proceedings of the National Academy of Sciences, show that high levels of the enzyme drive tumor growth. "Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that … Continue reading →

Durham, NC (PRWEB) June 12, 2013 Scientists report in the current issue of STEM CELLS Translational Medicine that they are close to developing a new and effective way to treat tooth decay that fully restores the tooth rather than requires it to be filled, capped or extracted. The method, which uses stem cells, could prove especially useful in treating the kinds of cavities leading to that most dreaded and painful procedure the root canal. Dental cavities and inflammation of the surrounding pulp is a challenging public health issue, as tooth decay not only can cause a patient great pain but it also can lead to other serious health issues including heart disease, explained Misako Nakashima, DDS, Ph.D., of the National Center for Geriatrics and Gerontology in Obu, Japan. Generally we treat deep cavities by capping the tooth and removing any inflamed pulp surrounding it. But this has limited success and the problem frequently progresses until the tooth must be removed. In this newest study, conducted by Dr. Nakashima and several of her NCGG colleagues along with scientists from Shin Nippon Biomedical Laboratories in Kagoshima and from the School of Dentistry at Aichi-gakuin University in Nagoya, the goal was to test … Continue reading →

The Science of Mesenchymal Stem Cells and Regenerative Medicine - Arnold Caplan PhD (Part 2) In part 2, Prof. Caplan discusses the two types of regenerative medicine: tissue engineering and in vivo tissue regeneration, hematapoietic and mesenchymal s... By: http://www.cellmedicine.com … Continue reading →

MOUNTAIN VIEW, Calif., June 10, 2013 /PRNewswire/ -- SanBio Inc., a California-based regenerative medicine company, announced today that the U.S. Food and Drug Administration has approved their Investigational New Drug application (IND) for the use of SB623, a novel allogeneic stem cell therapy product, in patients suffering from traumatic brain injuries (TBI's). This approval allows the company to proceed with a Phase 1/2a clinical trial testing the safety and feasibility of the therapy. The clinical trial is expected to be carried out at several major hospitals in the United States. "This is the second clinical program for SanBio," said Keita Mori, SanBio's Chief Executive Officer, "we see this as a clear validation of our development program and a significant broadening of the therapeutic application of our lead product SB623 for the treatment of unaddressed chronic neurological deficits." "We measure the responses of TBI patients to physical therapy every day. Progress is often painfully slow and incremental," said Dr. Daniel Lu, Principal Investigator, Neuroplasticity and Repair Laboratory and Director, Neuromotor Recovery Research Center, University of California, Los Angeles, "If this new cell therapy approach improves outcomes it could have a dramatic positive effect on many lives." About Traumatic Brain Injury: According … Continue reading →