Category Archives: Mesenchymal Stem Cells

Published in the journal Science and Technology of Advanced Materials Vol. 14, p. 025003 ( http://iopscience.iop.org/1468-6996/14/2/025003), the study found that a stiff or rigid environment not only enhances the function of existing cardiomyocytes (as has previously been shown), but also promotes the generation of cardiomyocytes from embryonic stem (ES) cells. It may therefor be possible to grow new heart muscle tissue from stem cells by manipulating the stiffness of the medium they're grown in. In living organisms, a type of adult stem cells called mesenchymal stem cells (MSCs) are extremely sensitive to the elasticity of different materials, when cultured outside the body. For example, soft growing matrices that mimic brain tissue promote the differentiation of MSCs into neurons, while rigid matrices that resemble bone tissue promote the differentiation of MSCs into bone cells. In this study, the UCLA team examined the role of matrix elasticity on cardiac muscle development using mouse and human embryonic stem cells, which were grown on different substrates of a silicon-based organic polymer that varied in stiffness. The team found that rigid matrices promoted the generation of more cardiomyocytes cells from ES cells. In addition, ES-derived cardiomyocytes displayed functional maturity and synchronization of beating when cultured … Continue reading →

Stem Cell Therapy - Blue Horizon Stem Cells By: Michael McDermott … Continue reading →

Tokyo, Apr 10, 2013 - (JCN Newswire) - Eisai Co., Ltd. announced today that it has presented preclinical research findings suggesting a potential inhibitory effect on tumor metastasis as a possible novel mechanism of action for anticancer agent Halaven(R) (eribulin mesylate, "eribulin") at the American Association for Cancer Research (AACR) 104th Annual Meeting ("AACR 2013"). Among the research findings presented by Eisai at AACR 2013 were gene expression profiling (GEP) analyses of multiple cancer cell lines, which confirmed that eribulin altered expression in epithelial-mesenchymal transition (EMT) gene sets. EMT was first recognized in the early 1980s and was long assumed to be a feature of embryogenesis in which embryonic epithelial cells acquire mesenchymal characteristics that lead to cell migration1; however, EMT has in recent years also been reported 2 to perform a role in numerous disease states in adult stages and, particularly in the acquisition of EMT phenotypes in epithelial cancer cells, to be highly relevant to the infiltration and metastasis of cancer. Eisai also presented a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) analysis of human breast xenograft tumors in rats, which confirmed that eribulin improved blood perfusion in the core of tumor tissues ("tumor core"). These findings indicated that … Continue reading →

A horse is given an injection of stem cells in a bid to promote healing in a tendon injury. Lauren Schnabel/Jessica Cross/Cornell Univ. Patients seeking unproven stem-cell therapies in the United States often run up against government restrictions. But Vintage Vinty Mark of Lovettsville, Virginia, had no difficulty getting such injections to treat an injured tendon in his leg. The leg improved dramatically, and Vinty went back to training to be a racehorse. New guidance from the US Food and Drug Administration (FDA) could, however, soon rein in veterinary uses of stem cells, a practice that has exploded in the United States over the past decade, even though most therapies are unproven. Many researchers and veterinarians say that the guidance, a draft of which the agency plans to issue by the end of the year, is overdue. But others worry that FDA interference could hamper research that could benefit animals and their human companions. In the absence of clear regulations, the industry has burgeoned. Vet-Stem, a company based in Poway, California, has provided stem-cell treatments to more than 5,000 horses, 4,300 dogs and 120 cats since treating its first patient in 2004. Kits provided by MediVet America, based in Nicholasville, … Continue reading →

By Dr Neil Counihan PUBLISHED: 16:00 EST, 6 April 2013 | UPDATED: 16:00 EST, 6 April 2013 A cheerful-looking 12-year-old boy is sitting in the dentists chair in my Kings Road clinic, grinning. Taking out a tooth is a much less traumatic process than it used to be: a bit of anaesthetic rubbed on the gums and a quick tug. It is painless and fast. Even so, its not something you look forward to. But this is Pierre Moullier, my nephew. He has been told that he is making medical history by allowing his tooth to be the focus of this report. And his mother my older sister Judy is in complete agreement. Recycled: Pierre Moullier, aged 12, is holding his milk tooth which may prove a saving grace in the future The Counihan family have undergone something of a revelation in the past eight months. As an orthodontist working predominantly with children, I believe that should childrens milk teeth require removal for orthodontic purposes, their parents ought to be having them, or at least a part of them, stored. The reason? Cells known as stem cells within those normally discarded bits of tissue have so many potential uses that … Continue reading →

Featured Article Academic Journal Main Category: Stem Cell Research Also Included In: Bones / Orthopedics Article Date: 05 Apr 2013 - 12:00 PDT Current ratings for: "Nanokicking" Stem Cells Offers Cheaper And Easier Way To Grow New Bone 3.57 (7 votes) Matt Dalby from the Centre for Cell Engineering at the University of Glasgow, and colleagues, write about their work in a study that was published recently in the journal ACS Nano. In a statement released this week, Dalby says their new method offers a simple way of "converting adult stem cells from the bone marrow into bone-making cells on a large scale without the use of cocktails of chemicals or recourse to challenging and complex engineering". Scientists have found it is possible to grow these tissue types in the lab by isolating MSCs and culturing them in an environment that simulates that which occurs naturally in the human body. But current methods of coaxing the stem cells to differentiate are notoriously problematic and require expensive and highly engineered materials or complex chemical cocktails. Nanokicking replicates a vibration that occurs in the membranes of bone cells when they stick together to form new bone naturally in the body. The vibration, … Continue reading →

Stem Cell Therapy Treatment for Duchenne Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. Stem Cell Therapy Treatment for Duchenne Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy PT assessment: 1) In walking, whole foo... By: neurogenbsi … Continue reading →

Stem Cell Therapy Treatment Improvements in Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. Stem Cell Therapy Treatment Improvements in Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Could stand with calipers and wal... By: neurogenbsi … Continue reading →

Stem Cell Therapy Treatment for Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. Stem Cell Therapy Treatment for Muscular Dystrophy by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Could stand with calipers and walker (after 7... By: neurogenbsi … Continue reading →

Stem Cell Therapy Treatment for Spinal Cord Injury by Dr Alok Sharma, Mumbai, India. Stem Cell Therapy Treatment for Spinal Cord Injury by Dr Alok Sharma, Mumbai, India. After Stem Cell Therapy 1. Ankle clonus/jerk in both legs has reduced. P... By: neurogenbsi … Continue reading →