Category Archives: Mesenchymal Stem Cells

Public release date: 8-Mar-2013 [ | E-mail | Share ] Contact: Katherine Barnes katherine.barnes@kcl.ac.uk 44-207-848-3076 King's College London Scientists have developed a new method of replacing missing teeth with a bioengineered material generated from a person's own gum cells. Current implant-based methods of whole tooth replacement fail to reproduce a natural root structure and as a consequence of the friction from eating and other jaw movement, loss of jaw bone can occur around the implant. The research is led by Professor Paul Sharpe, an expert in craniofacial development and stem cell biology at King's College London and published in the Journal of Dental Research. Research towards achieving the aim of producing bioengineered teeth bioteeth has largely focussed on the generation of immature teeth (teeth primordia) that mimic those in the embryo that can be transplanted as small cell 'pellets' into the adult jaw to develop into functional teeth. Remarkably, despite the very different environments, embryonic teeth primordia can develop normally in the adult mouth and thus if suitable cells can be identified that can be combined in such a way to produce an immature tooth, there is a realistic prospect bioteeth can become a clinical reality. Subsequent studies have largely … Continue reading →

Dentists could soon tell patients to throw away their dentures after scientists discovered a way to 'grow' new teeth coated in enamel. The technique involved growing cells from human gum tissue, then combining them with tooth stem cells taken from a mouse embryo. These cell clusters were then transplanted by researchers into an adult mouse kidney where they subsequently grew into teeth-like structures. The human-mouse hybrid teeth were also discovered to contain dentin - the key structural material of teeth - as well as hard protective enamel. There was also evidence of root formation. The two kinds of cell used were epithelial 'surface lining' cells from human gum tissue, and mesenchymal 'tooth' cells from the mouse embryo. Professor Paul Sharpe, who led the research at King's College said: "The human epithelial cells are capable of responding to signals from the embryonic tooth cells from the mouse to contribute to crown and root growth. "These accessible human epithelial cells are thus a realistic source for consideration in human tooth formation." At present it is not considered ethical or practical to use human embryos in dentistry. "The next major challenge is to identify a way to culture adult human mesenchymal cells to … Continue reading →

8 March 2013 Last updated at 20:12 ET Dentists may one day be able to replace missing teeth with ones newly grown from gum cells, say UK researchers. The team from King's College London took cells from adult human gum tissue and combined them with another type of cell from mice to grow a tooth. They say using a readily available source of cells pushes the technology a step nearer to being available to patients. But it is still likely to be many years before dentists can use the method. Other work has focused on using embryonic stem cells to create "bioteeth". It proved it could be done but is expensive and impractical for use in the clinic, the researchers said. In the latest study they took human epithelial cells from the gums of human patients, grew more of them in the lab and mixed them with mesenchyme cells from mice. The mesenchyme cells were cultured to be "inducing" - they instruct the epithelial cells to start growing into a tooth. Transplanting the cell combination into mice, researchers were able to grow hybrid human/mouse teeth that had viable roots, they reported in the Journal of Dental Research. Link: Researchers grow … Continue reading →

7:37am, Sat 9 Mar 2013 - last updated Sat 9 Mar 2013 Scientists have come a step closer to replacing missing teeth with implants grown from stem cells. Researchers managed to engineer hybrid human-mouse teeth coated in enamel with developing roots. It could mean that in future dentures are replaced by real substitute molars grown from "seeds" planted into a patient's jaw. Two kinds of cell were used to make the bioengineered teeth. Epithelial "surface lining" cells were taken from the gum tissue and mesenchymal cells from the mouse embryos. Mesenchymal stem cells can develop into a range of different tissues, including bone, cartilage and fat. Epithelial cells derived from adult human gum tissue are capable of responding to tooth-inducing signals from embryonic tooth mesenchyme in an appropriate way to contribute to tooth crown and root formation and give rise to relevant differentiated cell types, following in-vitro (in a living body) culture. These easily accessible epithelial cells are thus a realistic source for consideration in human biotooth formation. The next major challenge is to identify a way to culture adult human mesenchymal cells to be tooth-inducing, as at the moment we can only make embryonic mesenchymal cells do this. The … Continue reading →

New 'teeth' grown from mouse cells 4:59am Saturday 9th March 2013 in National News Press Association 2013 Scientists have come a step closer to replacing missing teeth with implants grown from stem cells. Researchers succeeded in engineering hybrid human-mouse teeth coated in enamel with developing roots. In future, it is hoped the work will lead to dentures being replaced by real substitute molars grown from "seeds" planted into a patient's jaw. The technique involved growing cells from human gum tissue and combining them with tooth stem cells from mouse embryos. The combination cell clusters were transplanted into adult mouse kidneys where they grew into recognisable tooth structures. Examination showed that they contained dentin - the main structural material of teeth - as well as hard protective enamel. There was also evidence of viable root formation. Two kinds of cell were used to make the bioengineered teeth. Epithelial "surface lining" cells were taken from the gum tissue and mesenchymal cells from the mouse embryos. Mesenchymal stem cells can develop into a range of different tissues, including bone, cartilage and fat. Professor Paul Sharpe, who led the research at King's College London's Dental Institute, said: "Epithelial cells derived from adult human gum … Continue reading →

COLUMBIA, Md.--(BUSINESS WIRE)-- Osiris Therapeutics, Inc. (OSIR) the leading stem cell company focused on developing and marketing products to treat medical conditions in inflammatory, cardiovascular, orthopedic and wound healing markets, announced today its results for the fourth quarter and full year ended December 31, 2012. Recent and Full Year Highlights With the approval of Prochymal, 2012 was an historic year for the entire field of stem cell medicine, said C. Randal Mills, Ph.D., President and Chief Executive Officer of Osiris. For Osiris, it was also a year of commercial transformation, having four products on the market and expanding capabilities in development, manufacturing, sales and marketing. Osiris is now a fully integrated commercial cell therapy company, well-positioned for future growth. Fourth Quarter Financial Results Revenues during the fourth quarter of 2012 were $3.1 million, including Biosurgery product revenues of $2.9 million compared to $0.8 million over the same period of 2011. Gross margin during the fourth quarter was 70% compared to 58% during the fourth quarter of 2011. Gross profit was $2.1 million during the fourth quarter of 2012 and $0.4 million during the same period of 2011. We reported a loss of $2.6 million in the fourth quarter of 2012. … Continue reading →

Alternatives to knee replacement... fibroblast growth factor as an aid to stem cell cartilage repair http://www.stemcellsarthritistreatment.com In our series on alternatives to knee replacement, let's go over some of the growth factors needed for cartilage growth and maintenance... let's talk about Fibroblast growth factor Fibroblast growth factors (FGF) are proteins that play a major role in the development of normal cartilage and bone. Genetic mutations that cause deficiencies of this protein result in significant skeletal abnormalities. In rat studies, FGF has demonstrated impressive abilities to stimulate cartilage repair in osteoarthritis. On the other hand FGF, under certain circumstances has been shown to inhibit the effects of other growth factors such as Insulin-like growth factor. Its use as an adjunctive ingredient in the application of mesenchymal stem cells for cartilage repair bears watching. http By: Nathan Wei … Continue reading →

Deborah Morosini of Weston has been appointed as medical director of the advisory board at Provia Labs Store-A-Tooth, a stem cell bank specializing in dental stem cell preservation. Dr. Morosini brings her personal family experience supporting and promoting stem cell research, along with her medical background to the new role. An MD pathologist, she also has a masters degree in social work, is a voice for cancer patients and a strong supporter of stem cell research. She was inspired by the philanthropic efforts of her sister Dana Reeve, a nonsmoker who died from lung cancer, and her brother-in-law Christopher Reeve, the late actor who played Superman, who had a passion for stem cell research for spinal cord injuries and other illnesses. After seeing their work, Morosini incorporated medical and philanthropic synergies in her career, spending the past decade as a biotech and pharmaceutical professional, and becoming an inspirational speaker to families dealing with medical hardships. As a scientist, I have seen that certain types of mesenchymal stem cells, such as those derived from bone marrow, already provide cures for diseases, and there is significant potential for cells extracted from dental pulp, said Morosini. As an individual, and through Chris and … Continue reading →

The Future of Regenerative Medicine: Dental Pulp Stem Cells and Dental Pulp Stem Cell Banking MIAMI, Florida (PRWEB) February 25, 2013 GeneCells Director of Research and Laboratory Operations, Dr. Todd Flower, spoke Friday, January 25th, 2013 at 10am, at the Marriott Hotel to a panel of more than 100 leading dentists from Tegucigalpa, Honduras. Media agencies who attended the conference included: Drogueria Americana is the only Dental Pulp (and cord blood) establishment to be offering this cutting-edge, regenerative medicine technology in Honduras. The program was kicked-off with a special introduction by Dr. Yisela Irasema Andino, who welcomed guests and shared her excitement on the companys successful expansion of its services to the Honduran Market. Very much like cord blood, a childs loose tooth, extracted wisdom and/or adult teeth and pulpectomy can provide first-rate stem cells that can potentially be used in cellular-therapy based applications down the road, said GeneCells Director of operations, Jose Cirino. With more than a decade of experience and deep roots in the Latin American community, we are uniquely poised to help families in the U.S., Latin America and the Caribbean make informed decisions regarding how they can preserve stem cells for their long-term health. This opportunity … Continue reading →

BMP needed for cartilage repair and growth in arthritis http://www.stemcellsarthritistreatment.com Bone morphogenic protein or BMP is an essential ingredient needed for normal cartilage development, growth, and repair. Mouse models deficient in this protein show significant deformities as do humans deficient in the gene responsible for BMP. BMP has been shown to stimulate cartilage growth from mesenchymal stem cells and enhance the production of collagen. However, it has also been shown that when implanted in areas away from where cartilage would normally grow, BMP led to the formation of ectopic bone, meaning bone growing in areas it shouldn't. http By: Nathan Wei … Continue reading →