Category Archives: Mesenchymal Stem Cells

One of the best kept secrets- Why is stem cell plasticity so important for arthritis treatment?.mp4 http://www.stemcellsarthritistreatment.com The blood contains cells with many forms and functions. The ultimate source of these cells is called the hematopoetic stem cell or HSC for short. One feature of an HSC is self- renewal, the ability to divide and still remain a stem cell. HSCs can also differentiate into more mature cells and this transformation is driven by cytokines (protein messengers) and growth factors. The best known source for HSCs is bone marrow. Along with HSCs in the marrow are other stem cells, the mesenchymal stem cells or MSCs. Multiple experiments have shown that HSCs are very plastic, meaning they can be coaxed into helping with the regeneration and repair of non-blood tissue. This has led to the idea that "adult" HSCs and MSCs, if placed in the proper environment can serve as a "repair shop" for connective tissues such as cartilage, muscle, and tendon, ligament, and bone. This property of plasticity makes stem cell repair and treatment of arthritis in the shoulder, elbow, hip, knee, ankle, hand, and other regions possible. http By: Nathan Wei … Continue reading →

CLEVELAND, Jan. 31, 2013 /PRNewswire/ -- Arteriocyte, a leading biotechnology company with offices in Cleveland, Ohio and Hopkinton, Massachusetts announced today approval from the Food and Drug Administration (FDA) to initiate a Phase I clinical trial using its Magellan System technology in the treatment of thermal burn wounds. The FDA Investigational Device Exemption (IDE-15140) allows Arteriocyte and its clinical partners to initiate evaluation of autologous platelet gel (APG) (using the Magellan Autologous Platelet Separator technology) as an adjunctive therapy for autologous skin grafting in patients with thermal injuries. This treatment has been developed in partnership with the United States Telemedicine and Advanced Technology Research Center (TATRC), and the University of Utah Health Science Center and Intermountain Burn Center. Arteriocyte is initiating a series of investigations employing Arteriocyte's Magellan Autologous Platelet Rich Plasma and Bone Marrow Derived Stem Cell Based Therapies for Burn Wounds as part of Arteriocyte's Cellular Therapies for Battlefield Wounds Program. The Magellan System is an FDA 510(k) cleared medical device for the rapid production of Platelet Rich Plasma from blood and bone marrow that can be applied to a surgical site as surgeons deem necessary for their clinical use requirements. Magellan MAR01a technology enables the rapid Operating … Continue reading →

Washington, January 31 (ANI): The Idu-Mishmi community of Arunachal Pradesh and RIWATCH (Research Institute of World's Ancient Traditions Cultures and Heritage) have made a great contribution in studying dormant Mycobacterium in TB that has affected nearly 4 billion people in the world and causing 1.9 million deaths yearly. TB is a huge problem in India. The incidence of this infectious disease is much more higher in Northeast of India and especially Arunachal Pradesh than rest of India. The doctors prescribe drug treatment for months together to the TB patients, however TB recurs leading to death and suffering. It was not clear as to how the bacteria of TB hide in the body from months of drug treatment. Now a new study has reported that the dormant TB hide in bone marrow stem cells to escape from drug treatment. The finding that could help develop better therapy to target the dormant TB bacteria. Dr. Bikul Das, who hails from Sualkuchi in Assam and engaged in doing research on stem cells in Stanford University California is known to RIWATCH and its' parent organization ICCS (International Center for Cultural Studies US) since long. When he was working as a Doctor in Bhutan, he … Continue reading →

By Alex Y. Vergara DR. VICKI Belo ARNOLD ALMACEN Is the elusive search for the fountain of youth over? Vicki Belo, one of the countrys leading beauty doctors, thinks so, as she recently unveiled her latest weapons in the fight against aging: intradermal (ID) and intravenous (IV) stem cell treatments. Developed by Russian doctors in Moscow after more than a decade of research, ID treatment, much like Botox, is injected directly on specific points of the face and neck to supposedly facilitate faster skin regeneration, tighten sagging muscles and promote the production of collagen and elastin, two of the skins most important building blocks. As we age, our skin tends to lose elasticity, said Belo. Since we dont produce as much collagen and elastin as we used to, our faces soon lose fat and become hollow. Wrinkles also start to deepen and permanently set in. This may sound a bit scary, but the stem cells Belo uses, unlike those used in a number of clinics abroad, including a famous one in Germany, dont come from animals like sheep. They are not sourced from embryos either. In a way, we pioneered stem cell therapy in the Philippines by using a persons … Continue reading →

New Delhi, Jan. 31: Scientists, using bone marrow samples from members of the Idu Mishmi tribe in Arunachal Pradesh, have discovered the hideout in the human body where tuberculosis bacteria can lie dormant for years. A collaborative study by Indian and US scientists has identified stem cells in the bone marrow that seem to serve as a "protective niche" for TB germs to evade the drugs' action and the human immune system. The study, published yesterday in the journal Science Translational Medicine, relied on samples of bone marrow provided by volunteers among Idu Mishmi tribals who live in a remote mountain range in Arunachal's Lower Dibang Valley. By volunteering to participate in the study, scientists say, this indigenous community has contributed to efforts to resolve a long-standing medicine mystery. While effective antibiotics have been available to treat and cure TB for more than 50 years, TB bacilli remain in the body despite a successful course of treatment and can cause the disease to recur after years or even decades. Now Bikul Das, at the Stanford University Medical Centre, and his collaborators have found that cells called mesenchymal stem cells (MSCs) in the bone marrow appear to provide a "long-term protective" … Continue reading →

Traces of the bacteria were identified in mesenchymal stem cells, which can produce specialised cell types including bone, fat and cartilage. Although the stem cells are typically found in the bone marrow they are also capable of moving to the lungs the ideal environment for tuberculosis bacteria. After testing their theory on mice in a previous study, the researchers carried out a small clinical trial in India where bone marrow biopsies were taken from nine patients who had been treated for tuberculosis and who had no traces of the bacteria in their respiratory tract. In eight of the nine patients, bacterial DNA could still be found in bone marrow stem cells, and in two of these cases living bacteria were found. Dr Bikul Das, lead author of the study, said: "Not only is this strong evidence that the tuberculosis can remain dormant in stem cells, but it shows that the living bacteria could be recovered from these cells after a long period of time. "It's also very suggestive of how the reactivation could be triggered: These stem cells are known to migrate to sites of injury or inflammation and begin dividing. So, migrating stem cells harbouring dormant bacteria might reactivate … Continue reading →

Biotech Showcase 2012_AlloCure AlloCure, Inc. is a pioneer in the development of cell therapies for the treatment of kidney disease and is a leader in the acute kidney injury field. The company's proprietary technology enables the isolation and expansion of mesenchymal stem cells (MSC), obtained via conventional bone marrow donation, which can then be administered off-the-shelf to any patient in need without requiring tissue matching or immunosuppressants. The company's most advanced program, AC607, targeting acute kidney injury, is entering phase 2 clinical development and represents the first cell therapy to treat this life threatening condition. http://www.allocure.com View AlloCure's Alliance for Regenerative Medicine member profile at alliancerm.org By: AllianceRegenMed … Continue reading →

Public release date: 30-Jan-2013 [ | E-mail | Share ] Contact: Vijay Swami vijayarunachal@gmail.com 91-360-221-1105 RIWATCH The Idu-Mishmi community and Arunachal Pradesh appeared on the world map today for its greatest contribution in studying dormant Mycobacterium in TB that has affected nearly 4 billion people in the world and causing 1.9 million deaths yearly. In India, one person is dying of TB every 3 minutes. The study details and the contribution of Idu-Mishmis of Arunachal Pradesh and RIWATCH (Research Institute of World's Ancient Traditions Cultures and Heritage) in accomplishing the study has been duly acknowledged in a research paper published in a reputed journal 'Science Translational Medicine' on 30 January 2013. Dr. Ista Pulu, a Doctor belonging to Idu Mishimi community, and Vijay Swami, Director of RIWATCH are the co-authors of the paper. Dr. Deepjyoti Kalita, a Doctor from Guwahati Medical College who participated in research study and Lab work at Roing is also a co-author from north east India. TB is a huge problem in North East India. The incidence of this infectious disease is much more higher in Northeast of India and especially Arunachal Pradesh than rest of India. There are special TB departments in every hospital to … Continue reading →

Tuberculosis can hide in peoples bone marrow, lying dormant after aggressive drug therapy and emerging years later to re-infect, according to a finding that may help explain why the disease is difficult to eradicate. One third of the worlds population, more than 2.2 billion people, are infected with the deadly bacteria that causes TB. A four-drug cocktail of antibiotics and other drugs are typically prescribed for a minimum of six months in an effort to wipe out the disease. Still, most remain vulnerable even after treatment. Investigators writing today in Science Translational Medicine said they have uncovered the first evidence of tuberculosis nestled in mesenchymal stem cells in the bone marrow of people treated for the disease. The bacterias hideout in the self-renewing cells, where they capitalize on protection from the bodys own immune system, may explain how the germs survive. The next step is to find out how a re-infection is triggered, and then how to stop it, researchers said. Tuberculosis has remained a terrible health threat despite the proliferation of knowledge, diagnostics and treatment, said lead researcher Antonio Campos-Neto, director of the Center for Global Infectious Diseases at the Forsyth Institute in Boston, in a statement. By gaining … Continue reading →

The rats completely recovered from a stroke within two weeks with stem cell therapy (Wiki Commons) Stem cell therapy administered shortly after a stroke could significantly increase the sufferer's chance of a complete recovery. When administered to rats within 30 minutes of suffering a stroke, the rodents made a full recovery within two weeks, a study showed. The research, published in BioMed Central's open access journalStem Cell Research & Therapy, found that stem cells from the bone marrow of fat can improve the recovery of rats following a stroke. Researchers at La Paz University Hospital found that treatment improved the amount of brain and nerve repair, as well as the animal's ability to complete tasks. Rats were treated intravenously with stem cells half an hour after a stroke. In humans, such rapid response is known to dramatically improve the outcome of victims. The researchers found improvements in the stem cell group within 24 hours of the treatment, compared to the control group. The FAST response advertising campaign has aimed to increase awareness of symptoms. Facial and arm weakness and speech problems suggest it is time to call emergency services. Human trials A delay in treatment can result in death or … Continue reading →