Category Archives: Stem Cell Research

The artificial structure shows promise as a tool for medical research, though it cannot develop into an actual baby. After an egg is fertilized by a sperm, it begins to divide multiple times. This process generates a small, free-floating ball of stem cells: a blastocyst. Within a mammalian blastocyst, the cells that will become the body of the embryo (embryonic stem cells) begin to cluster at one end. Two other types of cells, the extra-embryonic trophoblast stem cells and the endoderm stem cells, begin to form patterns that will eventually become a placenta and a yolk sac, respectively. To develop further, the blastocyst has to implant in the womb, where it transforms into a more complex architecture. However, implantation hides the embryo from view -- and from experimentation. In the study, Zernicka-Goetz wanted to replicate developing embryonic events using stem cells. Other scientists who have attempted the same thing have used only embryonic stem cells, but these experiments, though they have yielded embryoid bodies, have not been entirely successful. The artificial bodies never follow the same chain of events found in nature, and they lack the structure of a natural embryo. Zernicka-Goetz, a professor in Cambridge's Department of Physiology, Development … Continue reading →

Find out more from Dr Ross Macdonald at Proactive's CEO Sessions. Cynata Therapeutics (ASX:CYP) is a stem cell and regenerative medicine company that is developing a therapeutic stem cell platform technology, Cymerus. The technology addresses a critical shortcoming in existing methods of production of mesenchymal stem cells (MSCs) for therapeutic use. Cynata is now in a transition to a clinical stage company. Earlier this year Cynata announced a breakthrough strategic partnership agreement with Fujifilm which included the Japanese company investing in Cynata to become the largest shareholder in the company. Find out more from Dr Ross Macdonald at Proactive's CEO Sessions. Click on city below to register by email - Sydney: Tuesday 14th March. - Melbourne: Wednesday 15th March. - Email Pauline here. - Call office on (02) 9280 0700. Presenter list - Legend Mining (ASX:LEG): Mark Wilson. - Cynata Therapeutics (ASX:CYP): Dr Ross Macdonald. - White Cliff Minerals (ASX:WCN): Todd Hibberd. - Bluechiip (ASX:BCT): Andrew McLellan. Register here to be notified of future CYP Company articles Read more from the original source: Cynata Therapeutics talks stem cell research at Proactive's CEO Sessions - Proactive Investors Australia … Continue reading →

LONDON Technavio analysts forecast the global stem cell therapy market to grow at a compound annual growth rate of close to 37 percent during the forecast period, according to their latest report. The research study covers the present scenario and growth prospects of the global stem cell therapy market for 2017-2021. To determine the market size, the study considers revenue generated from allogenic and autogenic stem cell therapies. The Americas are the largest regional segment of the global stem cell therapy market, responsible for generating over 56 percent of the total revenue (2016 figures). The region is expected to continue market dominance through the forecast period, driven by increasing demand for stem cell therapy products and investments into R&D. Technavio analysts highlight the following factors as contributing to the growth of the global stem cell therapy market: Increase in federal funding in stem cell therapy. Sapna Jha, one of the lead research analysts at Technavio for medical imaging research, says, Many stem cell research institutes and small companies are involved in cutting-edge R&D and are yielding encouraging results. These institutions are witnessing an increased flow of investments from federal organizations, due to the realization of the importance of regenerative medicine. … Continue reading →

MENAFN Press - 05/03/2017 (MENAFN Editorial) -- RI Technologies' (www.researchimpact.com) market research report on Stem Cells is an innovative and empowering guide to the ever progressing and debatable market of Stem Cells Research. The market for Stem Cells is segmented by type, technology and therapeutic area. Stem Cells by Type are further classified into Adult Stem Cells, Cord Blood Stem Cells, Embryonic Stem Cells and Other. Stem Cells Research by Technology is segmented into Stem Cells Transplantation, CB Genomics, Xenotransplantation, Cord Blood Banking and Other. The Therapeutic applications of Stem Cells Research are analyzed by area into Neurology, Orthopedics, Oncology, Hematology, Cardiology, Dermatology, Diabetes, Hepatology and Other. Projections and estimates are graphically illustrated by geographic regions encompassing North America, Europe, Asia-Pacific, and Rest of World. Business profiles of 61 major companies are discussed in the report. The report serves as a guide to global Stem Cells Market size covering more 1000 companies that are engaged in stem cells R & D, storage, banking, discovery, testing and supply of products and services. The report also gives a comprehensive global list of 200 cord blood/stem cell banks. Major Contract Research Organizations and Universities serving the industry are also covered in the Corporate … Continue reading →

The artificial structure shows promise as a tool for medical research, though it cannot develop into an actual baby. After an egg is fertilized by a sperm, it begins to divide multiple times. This process generates a small, free-floating ball of stem cells: a blastocyst. Within a mammalian blastocyst, the cells that will become the body of the embryo (embryonic stem cells) begin to cluster at one end. Two other types of cells, the extra-embryonic trophoblast stem cells and the endoderm stem cells, begin to form patterns that will eventually become a placenta and a yolk sac, respectively. To develop further, the blastocyst has to implant in the womb, where it transforms into a more complex architecture. However, implantation hides the embryo from view -- and from experimentation. In the study, Zernicka-Goetz wanted to replicate developing embryonic events using stem cells. Other scientists who have attempted the same thing have used only embryonic stem cells, but these experiments, though they have yielded embryoid bodies, have not been entirely successful. The artificial bodies never follow the same chain of events found in nature, and they lack the structure of a natural embryo. Zernicka-Goetz, a professor in Cambridge's Department of Physiology, Development … Continue reading →

Researchers at Columbia University have retracted a 2013 paper in The Journal of Clinical Investigation, after uncovering abnormalities in the stem cell lines that undermined the conclusions in the paper. Last year, corresponding author Dieter Eglidiscoveredhe could notreproduce key data in the 2013 paper because almost all the cell lines first author Haiqing Hua used contained abnormalities, casting doubt on the overall findings. When Egli reached out to Hua foranswers, Hua could not explain the abnormalities. As a result, Hua and Egli agreed the paper should be retracted. Since some of the details of how the paper ended up relying on abnormal cells remain unclear, the university confirmed to us that it is investigating the matter. Heres the retraction notice for iPSC-derived cells model diabetes due to glucokinase deficiency, cited 42 times: The corresponding authors were made aware of karyotype abnormalities through a routine quality control test of pluripotent stem cells used in the studies reported in this paper. After extensive internal review and genetic analysis, they found that the karyotypes of some of the cells used for the experiments reported were abnormal and that the normal karyotypes shown in Figure 1 and Supplemental Figure 2 were not from cell … Continue reading →

Notes This is a 7-day-old embryo that scientists kept alive in a laboratory dish. If it developed further, the clusters in green would become cells that shape the body and the red/purple cells would form the placenta. Ali Brivanlou slides open a glass door at the Rockefeller University in New York to show off his latest experiments probing the mysteries of the human embryo. "As you can see, all my lab is glass just to make sure there is nothing that happens in some dark rooms that gives people some weird ideas," says Brivanlou, perhaps only half joking. Brivanlou knows that some of his research makes some people uncomfortable. That's one reason he has agreed to give me a look at what's going on. His lab and one other discovered how to keep human embryos alive in lab dishes longer than ever before at least 14 days. That has triggered an international debate about a long-standing convention (one that's legally binding in some countries, though not in the U.S.) that prohibits studying human embryos that have developed beyond the two-week stage. Ali Brivanlou's research team at Rockefeller University in New York was one of two groups internationally that figured out … Continue reading →

March 3, 2017 by Jeff Norris A molecular key to aging of the blood and immune system has been discovered in new research conducted at UC San Francisco, raising hope that it may be possible to find a way to slow or reverse the growing risk for aging-associated chronic inflammatory diseases, anemia, blood cancers, and life-threatening infections. The key is a link between the health of a rare population of adult stem cells that arise early in development and are responsible for replenishing all blood cell types throughout a lifetime, and a newly identified role for autophagy, an important cellular cleanup and recycling process that was the focus of the 2016 Nobel Prize in Physiology or Medicine. In their new study, published online March 1 in Nature, the UCSF team discovered that in addition to its normal role in cellular waste-processing, autophagy also is needed for the orderly maintenance of blood-forming hematopoietic stem cells (HSCs), the adult stem cells that give rise to red blood cells, which carry oxygen, and to platelets, which prevent bleeding, as well as the entire immune system, which fights infections and disposes of pathogens. The researchers found that autophagy keeps HSCs in check by allowing … Continue reading →

March 1, 2017 Neural progenitor cells (green) in the lateral ganglionic eminence (LGE), the region in the developing brain that produces the majority of adult neural stem cells. Credit: Sven Falk Neurodegenerative diseases such as Alzheimer's or Parkinson's, but also strokes or other types of traumatic brain damage, result in the death of nerve cells in the brain. Since the mammalian brain is capable of replacing nerve cells only in certain restricted regions, such nerve-cell loss is in most cases permanent. Similarly, the capacity to form new nerve cells in the mature brain is limited to specific areas. The cells responsible for neurogenesis in the mature brain are called adult neural stem cells, but little is known about their developmental origins. Now an international research collaboration led by Magdalena Gtz, Professor of Physiological Genomics at LMU's Biomedical Center and Director of the Institute for Stem Cell Research at the Helmholtz Zentrum Munich, has demonstrated that the mode of division of stem cells has a profound influence on the numbers of adult neural stem cells formed during embryonic development. The new findings appear in the journal Neuron. Neural cells develop from progenitors called neural stem cells, which are produced in large … Continue reading →

Researchers identified an adverse reaction in the fetlock joint of horses after giving them a second dose of mesenchymal stem cells from a donor. By contrast, no such reaction was found in horses receiving a second injection of the bone marrow-derived stem cells sourced from their own bodies, provided they had gone through a laboratory decontamination process first. Texas A&M University researchers have reported their findings, based on a study using 18 Quarter horses, in the journal Stem Cell Research & Therapy. The injection of mesenchymal stem cells into joints affected by osteoarthritis has been shown to be an effective therapy. However, Ashlee Watts and her colleagues noted that no direct comparison had been made of the response of the synovial joint to the injection of stem cells derived from the patients own body as opposed to a donor. The study team set out to assess the clinical response of each treatment, using stem cells prepared in a way that minimized protein contamination arising from laboratory techniques that used bovine serum as food for the cells in their preparation. The horses were divided into groups, with some receiving their own stem cells in a fetlock, some receiving donor cells from … Continue reading →