Category Archives: Stem Cell Research

History of Stem Cell Research The research that's been done with all types of stem cells has continued to tell us that it isn't necessary to destroy young human life to harness the potent... By: Thriving Values … Continue reading →

National Institute on Child Health Human Development Stem Cell Research Thomas Miller is a Post-Doc Fellow in the Section on Molecular Morphogenesis at the National Institute on Child Health Human Development. Thomas is trying ... By: LabTV … Continue reading →

Growing Spheroid Cultures for Cancer and Stem Cell Research To learn more about choosing the right surface for your research, watch our on-demand webinar: Growing 3D Cultures Consistently and Repeatedly: http://ow.ly/... By: Thermo Scientific … Continue reading →

19 hours ago (top) Adding 9 amino acids before Klf4 to switch the isoform from Klf4S to Klf4L subtly lengthens the transgene. (bottom left) This lengthening causes a significant increase in the Klf4 protein expression. (bottom right) It also increases the proportion of reprogrammed cells (green) to partially reprogrammed cells (red). Credit: Dr. Knut Woltjen's Laboratory Researchers at Kyoto University's Center for iPS Cell Research and Application discover a simple way to increase the production of induced pluripotent stem cells. A major hurdle in reprogramming science is generating a sufficient number of iPS cells to conduct basic research experiments. Yet, a report published in Stem Cell Reports shows that simply adding 9 amino acids to the induction transgene Klf4 dramatically elevates the production of fully reprogrammed mouse iPS cells. Anyone in the field of cell reprogramming recognizes Oct3/4, Sox2, Klf4, and c-Myc, or "OSKM", as the Yamanaka factors that led to the first iPS cells. Originally, these four genes were delivered as individual (monocistronic) viral vectors. In order to simplify protocols, researchers began to deliver them using single polycistronic vectors, where the OSKM genes are linked as mRNA but still produce four separate proteins to induce reprogramming. However, not all … Continue reading →

WSCS 2014: NEW PATHS TO THE FINAL FRONTIER: ENABLING STEM CELL RESEARCH IN SPACE FOR LIFE ON EARTH SUPPORTED BY CASIS Moderator - Michael S. Roberts, PhD, Center for the Advancement of Science in Space, Inc. Speakers - Carl Gregory, PhD, Texas A M Institut... By: worldstemcell … Continue reading →

Stem Cells Counting - NucleoCounter NC-200 WEBSITE http://chemometec.com/chemproducts/nucleocounter-nc-200/ During stem cell research NucleoCounter NC-200 Stem Cell Researchone of the important parameters is the precise ... By: ChemoMetec A/S … Continue reading →

The generation of neurons (neurogenesis) in humans is predominantly limited to development; in the adult stage it takes place in only a few regions of the brain. These regions contain neural stem cells that generate neurons in a process with various intermediary stages. Stem cell renewal is limited - total number drops Until now it was thought that maintaining the stem cell pool was based on the self-renewal of individual stem cells. The team of scientists headed by Dr. Jovica Ninkovic and Professor Dr. Magdalena Gtz were able to refute this: Both the self-renewal rate and the diversity of neurons formed from the stem cells are limited, and the number of stem cells decreases with age. "Our findings explain why neurogenesis declines in later years, as there are fewer and fewer neural stem cells. At the same time, we gained new knowledge on basic mechanisms of neurogenesis that until now were not understood," says first author Dr. Filippo Calzolari. Therapeutic approaches must focus on stem cells themselves Approaches to new therapies for brain diseases, such as stroke or dementia, for example, particularly concentrate on replacing lost neurons by stimulating the generation of new cells from stem cells. "In light of … Continue reading →

MINNEAPOLIS/ST. PAUL (2/10/2015) - A new reporter system used to study the bone regeneration potential of human embryonic stem cells has been generated in research led by the University of Minnesota. The new reporter system is the first of its kind for human pluripotent stem cells and is important for identifying certain agents and pathways that mediate early stages of human bone development. The research is published today in the journal Stem Cell Reports. The RUNX2-yellow fluorescent protein reporter system allows researchers to learn whether a human pluripotent stem cell-derived cell tests positive (or negative) for certain properties. Cells testing positive have been shown previously to repair bone in the skulls of immunodeficient mice. An improved understanding of whether a cell tests positive or negative through the RUNX2-yellow fluorescent protein reporter system will allow researchers to better monitor which types of cells produced from human pluripotent stem cells might be best suited to regenerating bone. The Stem Cell Reports publication comes on the heels of a complementary finding led by the same group of University of Minnesota researchers published in December in the journal Stem Cells. The Stem Cells publication specified a new reporter system to identify and isolate a … Continue reading →

WSCS 2014: 7TH ANNUAL IRB ESCRO AND SCRO WORKSHOP 7TH ANNUAL IRB ESCRO AND SCRO WORKSHOP: MEETING THE INSTITUTIONAL OVERSIGHT CHALLENGES TO STEM CELL RESEARCH Moderator - Melinda Abelman, MSc, CIP, Partners ... By: worldstemcell … Continue reading →

(February 19, 2015) - The New York Stem Cell Foundation (NYSCF) and the Stanley Center at the Broad Institute of MIT and Harvard are partnering to create a foundational stem cell resource to study psychiatric disorders through the production of induced pluripotent stem (iPS) cell lines from individuals with schizophrenia and other psychiatric disorders. This new partnership aligns NYSCF's mission to accelerate cures for the major disease of our time through stem cell research with the Stanley Center's goal to reduce the burden of serious mental illness through research. NYSCF is generating stem cell lines from skin samples of patients provided by the Stanley Center, which recently reported on the genotyping of more than 10,000 patients with schizophrenia. Research conducted using the stem cell lines generated will closely couple with ongoing genetic studies on the underpinning of psychiatric disease at the Stanley Center. "This is a great example of how two non-profit organizations can work together to advance a cause which, in the short term, will help us better understand a misunderstood and difficult condition. In the longer term, it will help provide important information and approaches for drug discovery," said Dr. Steven Hyman, Director of the Stanley Center for … Continue reading →