Category Archives: Stem Cell Transplant

Haploidentical Transplant When a HLA matched donor for a stem cell transplant can't be found a haploidentical transplant may be possible. The Cleveland Clinic Blood and Bone Marrow Tr... By: Cleveland Clinic … Continue reading →

By Joyce Ervin Special to The Milan News-Leader Pictured is a photograph of Danielle Peladeaus daughters, Jocelyn and Rachel on the GoFundMe website. Peladeau is raising funds for a stem cell transplant. She is a sufferer of the rare disease, Stiff Person Syndrome. As a suffer of the rare disease Stiff Person Syndrome, she finds herself now raising funds for herself to help pay for a stem cell transplant her insurance wont completely cover through the online non-profit GoFundMe. A rare disease is any disease that has fewer than 200,000 people diagnosed worldwide. There are only 300 people in the United States diagnosed with Stiff Person Syndrome Peladeau said, Unfortunately, it is progressive and there is no cure like many other diseases such as Amyotrophic lateral sclerosis also known as Lou Gehrig disease and Lupus, said Peladeau. Peladeau had to wait a long time to be considered a candidate for the treatment that her hematologist recommended that will take place in Chicago. In spite of the difficult logistics, Peladeau decided to go ahead with the transplant. She will remain there for six to eight weeks and it is recommended a caregiver stay with her for the entire time. She would … Continue reading →

CALDWELL Eleni Christoforou, 32, hopes that a hematopoietic stem cell transplant (HSCT) will strike a decisive blow in her decade-long battle with multiple sclerosis (MS). The Caldwell resident said the goal is to erase any memory of the disease from her body. However, even with insurance coverage, the procedure will cost Christoforou roughly $20,000 between traveling to Chicago, where the transplant is done, and the other costs associated with removing and reinserting her stem cells, as well as fertility treatments. Multiple sclerosis is an autoimmune disease that disrupts the brains ability to communicate with the body. The hematopoietic stem cell transplant will remove Christoforous stem cells from her bone marrow and then she will undergo chemotherapy before her own stem cells are injected back into her system with hopefully no memory of the MS, she explained. Christoforous first symptoms left her unable to walk up the stairs, bumping into walls, losing her memory and confused. There were days where she would forget how to get home or how she arrived at work, she said. She had a particularly bad episode in July of 2014 that left her unable to speak, walk, see and even feed herself. She spent a week … Continue reading →

Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options. The results appear in an upcoming issue of the journal Stem Cells. In sickle cell disease, a genetic variant causes patients' blood cells to take on a crescent, or sickle, shape, rather than the typical round shape. The crescent-shaped cells are sticky and can block blood flow through vessels, often causing great pain and fatigue. Getting a transplant of blood-making bone marrow can potentially cure the disease. But for patients who either cannot tolerate the transplant procedure, or whose transplants fail, the best option may be to receive regular blood transfusions from healthy donors with matched blood types. The problem, says Linzhao Cheng, Ph.D., the Edythe Harris Lucas and Clara Lucas Lynn Professor of Hematology and a member of the Institute for Cell Engineering, is that over time, patients' bodies often begin to mount an immune response against the foreign blood. "Their … Continue reading →

Stem Cell Transplant/ Bone Marrow Transplant By: 7721480 … Continue reading →

Contact Information Available for logged-in reporters only Newswise Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options. The results appear in an upcoming issue of the journal Stem Cells. In sickle cell disease, a genetic variant causes patients blood cells to take on a crescent, or sickle, shape, rather than the typical round shape. The crescent-shaped cells are sticky and can block blood flow through vessels, often causing great pain and fatigue. Getting a transplant of blood-making bone marrow can potentially cure the disease. But for patients who either cannot tolerate the transplant procedure, or whose transplants fail, the best option may be to receive regular blood transfusions from healthy donors with matched blood types. The problem, says Linzhao Cheng, Ph.D., the Edythe Harris Lucas and Clara Lucas Lynn Professor of Hematology and a member of the Institute for Cell Engineering, is that over time, patients bodies often begin to mount … Continue reading →

March 10, 2015 These are human blood cells grown in the lab from genetically edited stem cells. (Credit: Ying Wang/Johns Hopkins Medicine) Provided by Shawna Williams, Johns Hopkins Medicine Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options. The results appear in an upcoming issue of the journalStem Cells. In sickle cell disease, a genetic variant causes patients blood cells to take on a crescent, or sickle, shape, rather than the typical round shape. The crescent-shaped cells are sticky and can block blood flow through vessels, often causing great pain and fatigue. Getting a transplant of blood-making bone marrow can potentially cure the disease. But for patients who either cannot tolerate the transplant procedure, or whose transplants fail, the best option may be to receive regular blood transfusions from healthy donors with matched blood types. [STORY: New injection helps stem traumatic blood loss] The problem, says Linzhao Cheng, Ph.D. , the … Continue reading →

Since the first experimental bone marrow transplant over 50 years ago, more than one million hematopoietic stem cell transplantations (HSCT) have been performed in 75 countries, according to new research charting the remarkable growth in the worldwide use of HSCT, published in The Lancet Haematology journal. However, the findings reveal striking variations between countries and regions in the use of this lifesaving procedure and high unmet need due to a chronic shortage of resources and donors that is putting lives at risk. HSCT (also known as blood and marrow transplant) is most often used to treat diseases of the blood and several types of cancer such as multiple myeloma or leukaemia. For many people with these diseases the only possibility of a cure is to have a HSCT. The procedure provides healthy cells from either the patient (autologous transplantation) or from a healthy donor (allogeneic transplantation) to replace those lost to disease or chemotherapy. Using data collected by the Worldwide Network for Blood and Marrow Transplantation (WBMT), Professor Dietger Niederwieser from the University Hospital Leipzig in Germany and international colleagues, systematically analysed the growth of HSCT and changes in its use in 194 WHO member countries since the first transplant … Continue reading →

Black South Africans make up about 47 percent of all cancer patients but only 5 percent of donors in the nations bone marrow registry. The gap between those who may need bone marrow or stem cell transplants, and those able to provide them has deadly consequences for cancer patients. Black South Africans make up about 47 percent of all cancer patients but only 5 percent of donors in the nations bone marrow registry Maphoko Nthane, 50, had experienced mysterious and severe backaches for months. Doctors ran test after test, but could find nothing wrong with Nthane. I had a severe back ache for months, she told Health-e News. Whenever I would have that pain, I couldnt sit down I had to walk or stand up. Doctors eventually diagnosed Nthane with Acute Lymphoblastic Leukaemia, a severe form of cancer affecting a patients blood and bone marrow. After I was diagnosed I thought I was going to die I didnt know that people with leukaemia could live, Nthane said. My husband was just as traumatised and as a result he didnt know how to support me. Nthanes cancer failed to respond to standard chemotherapy and ultimately a stem cell transplant saved her … Continue reading →

First Successful Half Matched Stem Cell Transplant for Fanconi Anemia in India at Artemis A stem cell transplant also called a blood or marrow transplant is the injection or infusion of healthy stem cells into your body to replace damaged or d... By: Artemis Hospitals … Continue reading →