Category Archives: Ulcerative Colitis

Ulcerative colitis is a disease characterized by chronic inflammation of the colon (large intestine) accompanied in severe cases by ulcers in the lining of the colon. It is most often diagnosed in people between the ages of 15 and 30, although it can develop at any age, in both children and adults. The majority of patients have inflammation in their rectum, which spreads along the colon to varying extents. The inflammation may be limited to the: When more than just the left colon is affected, it is termed "extensive colitis." "Pancolitis" is the term used when the entire colon is inflamed. Ulcerative colitis is a chronic condition in which individuals experience both periods of active disease (flares/relapses) and periods of mild or inactive disease (remission). Typical symptoms include: Typical treatments involve anti-inflammatory medications (5-aminosalicylates) or immunomodulators (medications that modulate or suppress the immune system). Occasionally, medical treatment fails and surgical removal of the diseased colon becomes necessary. Ulcerative colitis is predominantly a disease of the the developed world, and is uncommon in the developing world, possibly due to a higher prevalence of intestinal infections in the developing world. The exact reasons why some individuals develop ulcerative colitis are unknown, although … Continue reading →

If youve just been diagnosed with Ulcerative Colitis (or even if youve had itfor some time)you may be feeling uncertain about what it is and the potential impact it may have on your life. Weve addressed some of the common questions about Ulcerative Colitis below. You can find more in-depth information in our freeUlcerative Colitis booklet. If youd prefer to speak to someone, were very happy to answer your questions through our Information Service. Ulcerative Colitis is a condition that causes inflammation and ulceration of the inner lining of the rectum and colon (the large bowel). In UC, tiny ulcers develop on the surface of the lining and these may bleed and produce pus. The inflammation usually begins in the rectum and lower colon, but it may affect the entire colon. If UC only affects the rectum, it is called proctitis, while if it affects the whole colon it may be called total colitis or pancolitis. Its one of the two main forms of Inflammatory Bowel Disease (IBD). The other isCrohns Disease. Ulcerative Colitis is a chronic condition. This means that it is ongoing and life-long, although you may have periods of good health (remission), as well as times when … Continue reading →

By Gerry Fraley , Staff Writer Contact Gerry Fraley on Twitter: ARLINGTON - Rangers left-hander Jake Diekman made a storybook return to the Rangers' bullpen on Friday night. Diekman, making his first appearance of the season, entered to a rousing reception from the spectators at Globe Life Park. He departed to a standing ovation after a scoreless inning during a 10-9 win against the Los Angeles Angels at Globe Life Park. Diekman soaked in the crowd response as he ran in from the bullpen during the seventh inning. He came off the field to a standing ovation after retiring all three hitters while performing his specialty: holding a lead. "I wanted to notice if it was there," Diekman said of the response to his appearance. "The fans, that was amazing. I just wanted to run toward the mound.'' Diekman spent the first five months of the season on the disabled list while undergoing three surgeries for ulcerative colitis. Manager Jeff Banister had hoped to bring Diekman into a low-stress situation for his first appearance but did not have that luxury. With Jose Leclerc unavailable after working two innings Thursday, Banister went to Diekman after Ricky Rodriguez faced four hitters without … Continue reading →

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A population-based study found an association betweenasthma andthe subsequent development of inflammatory bowel disease (IBD). Using health databases fromAlberta, Canada, the study examined 5,464 IBD patients (3,087 with Crohns disease and 2,377 with ulcerative colitis) and 402,800 controls. Researchers then looked at previous diagnosis of asthma in each of these groups. Results showed that there was a statistically significant chance of developing Crohns disease in patients previously diagnosed with asthma, regardless of the age at diagnosis of Crohns. Previous diagnosis with asthma was also significantly associated with the development of ulcerative colitis, but only in individuals diagnosed with ulcerative colitis before the age of 16 (3-16) and over the age of 40. There was no association between asthma and ulcerative colitis among individuals diagnosed between ages 17 and 40. Taken together, these results indicate that patients with asthma are at a higher risk of developing Crohns disease, and early and late onset ulcerative colitis. The study Asthma is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-Based Case-Control Study was published in the journal Clinical Gastroenterology and Hepatology. The researchers built on previous studies that showed there is an association between IBD and respiratory disorders, including asthma. Since asthma … Continue reading →

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Fortunately, there is a wide range of treatment options available that can help control ulcerative colitis (UC) as long as you stay on your treatment as prescribed. Getting ulcerative colitis under control and achieving remission (few or no symptoms) is a main goal of ulcerative colitis treatment. Often, the time with your doctor may be limited, so make it a priority to talk to your doctor about what you can expect from treatment and whether your treatment plan is working for you at every check-up. Talk to your doctor about finding a treatment that can help you reach these goals: Remember, if you still experience a flare-up of symptoms and are taking your treatment as prescribed, you may want to talk to your doctor about whether your treatment is right for you. Your doctor may reassess your medication depending on the severity of your symptoms (whether they are mild, moderate, or severe). Gastroenterologist Dr. Millie Long discusses treatment options and the importance of setting treatment goals. Millie Long, M.D., M.P.H., is an Associate Professor at the University of North Carolina Chapel Hill School of Medicine. Using this information, along with certain other tests and additional information, your doctor can help … Continue reading →

The U.S. Food and Drug Administration(FDA) has approved Boehringer IngelheimsCyltezo a biosimilar of Abbvies Humira (adalimumab) to treat Crohns disease,ulcerative colitis and a host of other diseases ranging from rheumatoid arthritis toankylosing spondylitis. Cyltezo is the German companys first FDA-approved biosimilar and marks an important step towards our goal of providing new and more affordable treatment options to healthcare providers and patients, Ivan Blanarik, senior vice-president and head of Boehringer Ingelheims therapeutic area biosimilars, said in a press release. The FDAs Aug. 29 decision is thesecond biosimilar of Humira after the approval of AmgensAmjevitain September 2016. Another biosimilar of Humira, Imraldiby Samsung Bioepis, won approval by the European Medicines Agency (EMA) on Aug. 24. The FDA granted its approval based on pharmacological, non-clinical and clinical data showing that Cyltezo is a biosimilar of Humira. The EMA is also expected to provide an opinion this year. A biosimilar is a drug that is shown to be highly similar to another existing biological drug, according to the FDA. It should have no clinically meaningful differences in terms of safety and effectiveness from the reference product. It is usually manufactured by a concurrent company after the patent for the original product has expired. … Continue reading →

WHAT IS ULCERATIVE COLITIS? Ulcerative colitis (UC) is an inflammatory disease potentially affecting the entire large bowel (colon and rectum). The inflammation is confined to the innermost layer of the intestinal wall (mucosa). UC can go into remission and recur. Medical management is typically the first option for treatment. If surgery is needed for UC, it is usually curative. RISK FACTORS Men and women are affected equally and people of all ages can develop UC. A family history of UC slightly increases the risk of the disease. CAUSES The exact cause of UC is unknown, but it is not contagious. Potential causes include immune system abnormalities and bacterial infection. SYMPTOMS Most patients develop symptoms in their 40s. A smaller number experience symptoms for the first time later in life (ages 60 to 70). The symptoms of UC are similar to Crohns disease, when the latter only affects the colon and rectum. The most common symptoms of UC include: DIAGNOSIS The first step is to undergo a thorough medical history and physical exam. Following this, additional testing may be needed. This may include blood tests, a complete colonoscopy of the rectum, colon and terminal ileum (the end of the small intestine … Continue reading →

The European Commission has approved Imraldi, an adalimumab biosimilar referencing AbbVies Humiramaking the medication available to treat the same therapeutic indications as Humira, including Crohns disease, pediatric Crohns disease and ulcerative colitis. The Aug. 24 decision followed a positive recommendation by the European Medicines Agencys Committee for Medicinal Products for Human Use, released in June. Todays decision marks another positive step in transforming the lives of people with chronic autoimmune conditions, Jean-Paul Kress, Biogens executive vice-president and head of global therapeutic operations, said in a press release. As the number of approved biosimilars continues to grow, so does the anticipated potential to increase physician choice and patient access to biologics. Imraldi was developed by Samsung Bioepis, a joint venture between Biogen and Samsung BioLogics. It is Biogens tgurd anti-TNF biosimilar medicine to receive European marketing approval following Benepali, an etanercept biosimilar referencing Enbrel,and Flixabi, an infliximab biosimilar referencing Remicade. The approvalwas supported by strong preclinical and clinical data demonstrating Imraldis safety and efficacy profiles. Clinical data included results from a Phase 1 trial (NCT02144714) in healthy volunteers, and a Phase 3 study (NCT02167139) in rheumatoid arthritis patients that compared Imraldi with Humira. That Phase 3 trial of544 patients with moderate-to-severe … Continue reading →