Category Archives: Ulcerative Colitis

In ulcerative colitis, tiny ulcers develop on the surface of the lining of the large bowel. Experts believe a fast, simple test for ulcerative colitis could provide a cheaper less invasive alternative for screening. A colonoscopy is currently the main test for the condition. Research by the Department of Physics and Astronomy and the Institute for Biomedical Sciences at Georgia State University found the testing procedure could more easily screen patients for ulcerative colitis. A colonoscopy is a test which allows a doctors to look at the inner lining of the large intestine - which includes the rectum and colon, every five years or more frequently if abnormalities are found. The test can help find ulcers, colon polyps, tumour and other areas of inflammation. However, the procedure is uncomfortable and can also be expensive. Experts said there was a need to be able to diagnose inflammatory bowel disease more effectively. Dr A G Unil Perera, Regents' Professor of Physics, said: Colonoscopy is used as a screening technique, so even if you dont know if a person has colitis or not, thats the only way to check and say they do. We are not talking about replacing colonoscopy. We have shown … Continue reading →

Takeda Pharmaceutical Companyhas submitted a new drug application to Japanese regulators for vedolizumab (MLN0002) as a treatment for adults with moderate to severe ulcerative colitis. Ulcerative colitis is a chronic, progressive inflammatory disease of the large intestine, which typically affects young adults,Toshiro Heya, head of Takeda Development Center Japan, said in a press release. The disease has a high impact on their quality of life, with symptoms including diarrhea, rectal bleeding, incontinence and abdominal pain.Through this submission [new drug application], we may provide an alternative treatment option to the increasing number of people with UC in Japan. In Japan, the agency that approves new drugs is theMinistry of Health, Labor and Welfare. Two Phase 3 clinical trials showed vedolizumab to be effective against ulcerative colitis. CCT-101 (NCT02039505) was a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. It looked at the effectiveness, safety, and pharmacokinetics of vedolizumab in 292 Japanese patients with moderate or severe ulcerative colitis.Pharmacokinetics refers to the bodys effect on a drug. Takeda plans to present the trial results at a scientific conference. GEMINI I (NCT00783718) was an international, randomized, double blind, placebo-controlled trial that assessed vedolizumabs effectiveness in 895 patients with moderate to severe ulcerative colitis. We aim … Continue reading →

OCEAN CITY An estimated 1,000 people walked and ran in the Guts and Glory 5K Sunday morning, supporting research and treatment of Crohns disease and ulcerative colitis. This years event honored a 12-year participant of the run/walk, 24-year-old Ashlynn Vanaria. Vanaria was diagnosed with Crohns in fifth grade, having her whole world change with a restrictive diet, a series of medical tests and daily doses of medication. Vanarias family has a vacation home in Ocean City and began participating in the Guts and Glory 5K in 2005, raising more than $50,000 over the years. This year, Team Ashlynn came in fourth place for top team fundraisers, raising $3,820. John Diedrich said he first heard about the race 11 years ago and thought it would be a good way to support his wife, Meredith, and his uncle, who both have forms of Crohns, colitis and irritable bowel disease. The first year Diedrich ran by himself. Now, as the captain of Team4Mer, he and the nearly 150 team members helped raise more than $31,000. For many years, people hid the fact that they had problems with their colon. I think now its becoming more acceptable and theres more education that people can … Continue reading →

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The rate of colorectal cancer has increased among young adults. Patti Singer Ulcerative colitis sufferers deal with frequent trips to the bathroom.(Photo: champja, Getty Images/iStockphoto) When someone tells you they are having a crappy day, if they are like me, theyliterally may be having one. I have ulcerative colitis. If youre thinking, what is that? Youre not alone. When I was diagnosed 17 years ago, I had no idea what my doctor was saying when after extensive blood work and a colonoscopy I was given the diagnosis. What is this guy talking about? NEW TO THE CLUB: My journey to becoming a mom FED IS BEST: Keeping my child happy and healthy on my own terms I went home and did my research. And more research. Please heed my advice and dont Google everything, especially when it comes to your health. I was 19, in college, and working part-time, but reading about my condition (there is no cure) and all the side effects (trouble conceiving a child. And I wasnt even sure I wanted kids) upset me. I had a flare-up in 2013 and posted this photo on social media to show the effect of the medicine I was about … Continue reading →

Marvel Custom Solutions has partnered with Seb Tucknott, the founder of the online platform IBDRelief and pharmaceutical companyTakeda,to create a new team of superheroes who all have one thing in common:inflammatory bowel disease (IBD). MORE:Sevenpeople with chronic illnesses who used a body-shaming experience to raise awareness According to a report on metro.co.uk, the Unbeatables are allaffected by either Crohns disease or ulcerative colitis, along with an estimated onein 250 Britons. While fighting crime and protecting people around the world, the Unbeatables also pause to consider how their superhero actions may affect their IBD, including the impact of stress. The team is made up of five characters: Marvel has created a full graphic novel featuring the adventures of the Unbeatables to raise awareness of IBD. The first chapter was revealed at Londons Comic Con to more than 100,000 Marvel fans. The cover of the novel was created by Marvels Kirbi Fagan, an illustrator who also lives with Crohns disease. MORE: Seven famous personalities with ulcerative colitis IBD News Todayis strictly a news and information website about the disease. It does not provide medical advice,diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or … Continue reading →

Several hundred people are expected to turn out in Ocean City this weekend in support of research and treatment for people with Crohns disease and ulcerative colitis. Ocean City will host the Crohns and Colitis Foundations Guts and Glory 5k run and walk Sunday and organizers said they are expecting as many as 1,800 race participants. Crohns and colitis are digestive diseases impacting more than 1.6 million American adults and children, according to the foundation. Patients often experience a range of symptoms and flare-ups throughout their lives, including, but not limited to, weight loss, fatigue, internal tearing and bleeding and abdominal cramps. There is no cure for Crohns disease, but doctors and other specialists are able to treat people in order to manage the condition with medications like corticosteroids, antibiotics and biological therapies. Advocates and supporters can register for the race online up until 12 p.m. Saturday or in person Sunday from 7:30 to 8:25 a.m. before the race at the Aquatics and Fitness Center, 1735 Simpson Ave., Ocean City. Pre-registered racers can pick up their event packets at the fitness center Saturday from 2:30 to 6 p.m. This years race will spotlight its 2017 honored hero, Ashlynn Vanaria, of … Continue reading →

The U.S. Food and Drug Administration has granted an orphan-drug designation to cobitolimod for the treatment of ulcerative colitis in pediatric patients The U.S. Food and Drug Administration (FDA) has granted an orphan-drug designation to cobitolimod for the treatment of ulcerative colitis in paediatric patients. We are pleased that the FDA has granted orphan-drug designation for cobitolimod for treatment of ulcerative colitis in children, which may provide seven years of market exclusivity in this indication on the US market, saidPeter Zerhouni, CEO of InDex Pharmaceuticals. Cobitolimod is a new type of drug that can help patients with moderate to severe ulcerative colitis back to a normal life. It is a so-called Toll-like receptor 9 (TLR9) agonist, that can provide an anti-inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis. Cobitolimod has achieved clinical proof-of-concept in moderate to severe active ulcerative colitis, with a very favourable safety profile. Data from four placebo-controlled clinical trials indicate that cobitolimod has statistically significant effects on those endpoints that are most relevant in this disease, both from a regulatory and clinical perspective. These endpoints include the key clinical symptoms such as blood in … Continue reading →

Early data from a Phase 1b clinical trial show that the investigational therapy TD-1473 for patients with ulcerative colitis (UC) has demonstrated targeted action and effectiveness, according to the therapys developer and study sponsor,Theravance Biopharma. Preliminary data are from four weeks of treatment. The ongoing study (NCT02818686), which currently is recruiting participants, is for patients with moderate to severe active UC. TD-1473 is an orally administered, highly specific inhibitor of the Janus kinase (JAK) family of enzymes, which plays a key role in inflammation. Most importantly, TD-1473s activity is restricted to the intestinal tract, which prevents the risk of systemic exposure and unwanted side effects. The study was designed to evaluatethe treatments safety, tolerability, and pharmacokinetics (a therapys behavior in the body) in UC patients during a 28-day period. Additional endpoints include assessing TD-1473s biologic effects by analyzing disease biomarkers and performing a thorough evaluation of clinical and endoscopic parameters. In the exploratory study, 10 patients from the first cohort received 80 mg of TD-1473 once a day for 28 days, while a control group of three patients received a placebo. Preliminary results from the first cohort revealed that TD-1473 induced a localized response (restricted to the intestine) with minimal … Continue reading →

GET INVOLVED Summer is a great time to get involved with the Crohn's & Colitis Foundation! Join the Team Challenge Family -- 10 years of racing for curesWhen you join the Team Challenge family,you're supported by coaches, mentors, and friends who understand the impact of IBD. Join us this year at a 5k, 10k, half marathon, marathon, triathlon, IRONMAN, cycle event -- or, turn anything else into a fundraiser when you Race in Orange. Learn more. 2017 spin4 crohn's & colitis cures lineup just announced!It's not too early to join the movement at one ofour 2017 spin4 crohn's & colitis cures fall events. The time is now -- grab some friends, reserve your bike, and join this fun indoor cycling relay! I want to #partyonabike! Click on the arrow to select your state to find information on your local Chapter. Enter your email address to receive the national newsletter and enter your zip code to receive your local chapter newsletter. Click on the arrow to view various topics applicable to Crohn's disease and ulcerative colitis.More in Resources Read more: Crohn's | Colitis | IBD | Crohns & Colitis Foundation … Continue reading →