Category Archives: Ulcerative Colitis

5 hours ago HYA, a microbial metabolite of linoleic acid, ameliorates intestinal barrier damage. Credit: Tanebe et al, The Journal of Biological Chemistry, DOI: 10.1074/jbc.M114.610733, FIG.3A Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food. The results of this group's research were published in The Journal of Biological Chemistry as "A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway" DOI: 10.1074/jbc.M114.610733. IBD patients characteristically demonstrate increased expression of tumor necrosis factor receptor-2 and an upregulated inflammatory NF-B pathway. Professor Tanabe and his colleagues demonstrated that HYA binds to a G protein-coupled receptor (GPR40) and ameliorates intestinal epithelial barrier impairment in an intestinal epithelial cell line, Caco-2 cells; oral administration of HYA also alleviates colitis in mice. The physiological activity of gut microbial metabolites has recently attracted considerable attention. HYA may be … Continue reading →

Life with Ulcerative Colitis | Introduction (Battlefield Hardline Commentary) So for a while I've wanted to speak openly on the condition I suffer from in a video commentary format to speak of my experiences with IBD (In my case, Ulcer... By: Mistr Labigmac … Continue reading →

INFLAMMATORY BOWEL DISEASE - CROHN DISEASE ULCERATIVE COLITIS Dr. JJ discusses inflammatory bowel disease, how it behaves, how it is diagnosed, and what differentiates it from irritable bowel disease. By: JJ Levenstein, MD, FAAP … Continue reading →

Hanneke Explains Managing Her Ulcerative Colitis Part 1 Hanneke was diagnosed with ulcerative colitis several years ago and has found success with melamine based medicine. She mentions some of the tricks she has l... By: iHaveUC … Continue reading →

Hospital Vlog | After My Surgery A vlog I made while in the hospital after having my colon removed =) I no longer have Ulcerative Colitis! I have an amazing ileostomy now! Here are the songs playing in the background if... By: Spyder1246 … Continue reading →

Ulcerative Colitis Ulcerative colitis is an inflammatory bowel disease (IBD) in which the lining of the large intestine (colon or bowel) and the rectum become inflamed. This inflammation produces tiny sores or ulcers on the lining of the colon. It usually begins in the rectum and spreads upward. It rarely affects the small intestine beyond the lower portion. The inflammation causes the bowel to move bowel contents rapidly and empty frequently. As cells on the surface of the lining of the bowel die, ulcers (open sores) form. The ulcers may cause bleeding and discharge of mucus and pus. This disease affects people of all ages. Symptoms tend to develop when people are between the ages of 15 and 30, or between the ages of 50 and 70. The cause of this condition is not known. Researchers no longer believe that it is caused by stress. Today, research focuses on the immune system and heredity for possible causes. Most people with ulcerative colitis dont have a family history of the condition. However, you are more likely to develop it if a close family member also has the condition. Ulcerative colitis can develop in a person of any race, but it is … Continue reading →

Success with Remicade Stephanie's Ulcerative Colitis Q A Part 2 Answer to the question "When Does Remicade Start Working" and several other questions related to an ulcerative colitis patient's perspective on using Remicad... By: iHaveUC … Continue reading →

My Story: Ulcerative colitis Finally telling my story. By: creativebeauty … Continue reading →

Retocolite ulcerativa complicada por cncer do reto / Rectal cancer complicating ulcerative colitis No presente vdeo, demonstra-se o diagnstico endoscpico do cncer do reto (adenocarcinoma) em paciente portador de colite esquerda (RCUI) de longa evoluo... By: Colorretal … Continue reading →

Nursing school made easy: nclex review, ulcerative colitis, Crohn's disease. By: Skeezy C … Continue reading →