Category Archives: Vascular Biology

BY DR. PAUL DIMUZIO The vascular system involves the heart and blood vessels. Continue reading →

Cho, Jaehyung Gus Ph.D., University of Wisconsin-MadisonAssociate Professorthromres@uic.edu Research InterestsCardiovascular Biology, Immunology, Vascular Biology Research Description Mechanisms regulating platelet-neutrophil-endothelial cell interactions during thrombosis and inflammation; intravital microscopy in live animals. Continue reading →

AbstractFor many years, advances in understanding steroid hormone action typically proceeded through sequential stages that involved first identifying the role of a putative hormone, then isolating it, often from large quantities of body fluid, and ultimately identifying the nuclear receptor through which the cellular effects were being achieved (1). More recently, this stepwise progression has been reversed by modern molecular biology techniques allowing rapid identification of many genes as encoding nuclear receptors based on structural motifs even without any information regarding the functional role of these so called orphan receptors. This process has been termed reverse endocrinology (1). Peroxisome proliferator-activated receptors (PPARs) were examples of such orphan receptors, although their status changed through the serendipitous discovery of synthetic ligands that could bind to PPARs (2). The fact that these synthetic agonists are now in clinical use for treating diabetes mellitus (DM) and dyslipidemia has helped draw attention to this nuclear receptor subfamily and its potential as a therapeutic target (3). The identification of a possible role for PPARs in inflammation and atherosclerosis has only heightened this interest (4). Share the post "PPARs and Their Emerging Role in Vascular Biology, Inflammation, and Atherosclerosis Springer" Link: PPARs and Their Emerging Role in … Continue reading →

Invitation It is my great pleasure to invite you to participate in the 13th International Conference on Cerebral Vascular Biology (CVB 2019) from June 25 28, 2019 in Miami, Florida. CVB 2019 will be a forum for scientists from around the world to discuss their cutting edge research on CNS barriers, particularly the blood- brain barrier (BBB) and blood-cerebrospinal fluid-barrier (BCSFB). This will be the continuation of a very successful conference series that was initiated in 1992. The last three conferences took place in Montreal, Canada (2013); Paris, France (2015); and Melbourne, Australia (2017). The CVB conference is returning to the US after 16 years of absence as the most important conference related to cerebral vascular biology. The participants will discuss current and future research surrounding cerebral vascular biology, including development of the brain barriers, drug transport and delivery across the BBB and BCSFB, the role of brain barriers in the etiology and pathology of neurological diseases, and therapeutic strategies to reverse these diseases by targeting the BBB and BCSFB. The emphases will be placed on novel nanotechnologies of drug delivery into the brain and clinical research on disorders involving cerebral vasculature. This exciting program will therefore attract national and … Continue reading →

Pre-Conference Meeting for Trainees Organizers: Nicholas Chavkin, Yale University and Thanh Theresa Dinh, Stanford UniversitySunday, October 14 - 1:00-5:00pmRequires an additional registration fee of $25. Program will consist of a guest speaker, a discussion or presentation on career development and abstracts presentations from graduate students and postdocs. Refreshments will be served *Session organizers will select the abstracts for presentation and the authors must be registered for this session. Wednesday, October 17 - 2:00-4:00pm Earl P. Benditt Award LectureReengineering the tumor microenvironment to improve cancer treatment: Bench to bedsideRakesh K. Jain, Massachusetts General Hospital, Harvard Medical School Judah Folkman Award in Vascular Biology LectureMolecular and cellular mechanisms of blood vessel growthChristiana Ruhrberg, University College London Springer Junior Investigator Award Lecture TBD - award is based on abstract submission and an applicationClick here for application information Recipients have not yet been determined Tuesday, October 16 - 4:30-6:30pmHands-on worskhop to access, visualize and analyse IDG-specific data -- requires additional registration fee and there will be a limited number of attendees Signaling in Vascular InflammationThursday, October 18 - 8:00am-12:00pm Timothy Hla, Boston Childrens Hospital, Harvard Medical SchoolNovel approaches to control vascular inflammation with S1P-based therapeuticsMatthias Nahrendorf, Massachusetts General Hospital, Harvard Medical SchoolMyeloid cells in … Continue reading →

Alternative Titles:Pteridophyta, cryptogam, pteridophyte, seedless vascular plant, vascular cryptogam Lower vascular plant, formerly pteridophyte, also called vascular cryptogam, any of the spore-bearing vascular plants, including the ferns, club mosses, spike mosses, quillworts, horsetails, and whisk ferns. Once considered of the same evolutionary line, these plants were formerly placed in the single group Pteridophyta and were known as the ferns and fern allies. Although modern studies have shown that the plants are not in fact related, these terms are still used in discussion of the lower vascular plants. Vascular plants are those that possess a specialized conducting system for the transport of water, minerals, and food materials, as opposed to the more primitive bryophytesmosses and liverwortswhich lack such a system. They include both the seed plantsangiosperms and gymnosperms, the dominant plants on Earth todayand plants that reproduce by sporesthe ferns and other so-called lower vascular plants. The pteridophytes represent the oldest of land plants. In their early evolution (during the Devonian and Carboniferous periods, 416 million to 299 million years ago), there were many forms that are now extinct. The sphenophytes, for example, were once a large and diverse group of herbs, shrubs, vines, and trees but are now limited to … Continue reading →

Mission Statement: Pulmonary vascular disease is a growing problem in many systemic diseases. In disease states, such as systemic sclerosis and hemolytic anemias, in which patient survival has increased dramatically in recent years, pulmonary complications, especially vascular ones, have become the leading cause of morbidity and mortality. The mechanisms involved in development of pulmonary hypertension (PH) regardless of etiology is not well-understood. The object of our studies is to define pathogenic mechanisms, essential for the development of these vascular abnormalities and use them to try to direct new therapies. Lastly, each of these entities can be associated with relative or absolute hypoxemia; thus, we have been investigating the effects of hypoxia on pulmonary vascular endothelium and methods to mitigate its effect. The projects in our research group are linked by the underlying pulmonary vascular abnormalities they engender: Approximately 6-10% of adults with sickle cell disease have pulmonary hypertension which is an independent risk factor for mortality. We have been interested in studying genetic modulators of sickle cell disease that place patients at risk for the development of PH. We are in the process of performing genome wide association studies of the largest cohort of prospectively collected SCD patients with cardiopulmonary … Continue reading →

Invitation to the 3rd joint ESM-EVBO meeting 2019 April 15 18 2019, Maastricht, Netherlands Improving vascular health is an important goal to pursue, as cardio-vascular diseases account for almost half of all deaths in Europe. Disturbances in normal (micro)vascular biology are at the basis of many diseases. From classical cardiovascular diseases, like myocardial infarction and stroke, to cardiometabolic diseases, like dementia, cognitive decline, heart failure, chronic kidney disease, diabetes, hypertension, and to cancer, post-surgical tissue regeneration, and wound healing. This broad range of diseases clearly underlines the need to expand our knowledge on the basic mechanisms underlying the disturbances in normal (micro)vascular biology. With this conference we aim to address many aspects of these mechanisms through state-of-the-art symposia and workshops. From April 15 to 18, 2019 we welcome you to Maastricht, one of the oldest and certainly most beautiful cities of the Netherlands. Maastricht has for many years a strong basis in cardiovascular research in the CARIM School for Cardiovascular Diseases, which is one of the largest cardiovascular research institutes in Europe. This, together with the warm and hospitable atmosphere of Maastricht will ensure an exciting and fruitful stay. On behalf of the national organizers: Jaap van Buul, Ed Eringa, … Continue reading →

Web Resources for Use in this Course NOTE: Fall 2005 BI211 is being taught by Prof. Judy Stone. Her syllabus and schedule are not the same as found here (used in Fall 2004 by Prof. Phillips). Prof. Stone and her students are free to use any appropriate resources found here. Syllabus Goals for the course, exam schedule, plant collection requirements, and family recognition information. Schedule Lecture and laboratory schedule and reading assignments. Lecture/Lab Slides Many of the computer images used in the lectures and laboratory are being placed on the web here for you to review. Computer Resources for Downloading: Click here for a Microsoft Word document containing the sylabus and schedule. Click here for a Macintosh version of the polyclave key for flowering plant family identification. Click here for a Windows application (MEKA) that implements the polyclave key for flowering plant family identification. Click here to download Macintosh software (MacClade 2.1) for cladistic analysis. Click here to download a MS Word document of blank herbarium labels. Guide to Flowering Plant Family Recognition This is a descriptive and photographic tour of some families in the Magnoliophyta. These still developing pages can help students learn to recognize on sight members of … Continue reading →

The Vascular Cell Biology Gordon Research Conference is focused on integrative aspects of vascular biology and pathology. The main goal of the Conference is to discuss the emerging biological and translational concepts in the field, to provide an opportunity to learn about the most recent data and new experimental approaches. The conference will address the basic biology of vascular cells and the reciprocal connections between vasculature and human diseases ranging from cardiovascular, neurovascular and metabolic diseases to organ fibrosis and cancer. The program includes sessions focused on fundamental aspects of vascular biology, e.g. mechanisms of vascular specification and development, vascular cell differentiation, inflammation, vascular metabolism and mechanobiology of vascular and lymphatic systems. These will be combined with discussions of newer areas of vascular biology, e.g. regulation of vascular cell fate and its role in disease, advances in endothelial targeting, novel regulatory networks in vascular inflammation and aging. In parallel with human studies, various experimental models ranging from zebrafish to mouse will be discussed. The program includes a new afternoon session on career development, inclusion of women and minorities, discussion of specific opportunities for junior investigators in academia and industry, and international visibility of the next generation of vascular biologists. Every … Continue reading →