Cynapsus Therapeutics Inc. : Cynapsus Therapeutics Publishes White Paper on Apomorphine for 'Off' Periods in Parkinson …

May 15, 2013

TORONTO - Cynapsus Therapeutics Inc. (CTH:TSX-V), a specialty pharmaceutical company developing the only known orally administered (sublingual) formulation of apomorphine, the only drug approved to treat the immobility ("off") symptoms of Parkinson`s disease, has completed a white paper providing background clinical information on apomorphine. The paper identifies the potential benefits of APL-130277, the company`s proprietary, patented, sublingual thin-film strip system, specifically its ability to deliver apomorphine to patients in a more convenient and more well-tolerated manner.

Anthony Giovinazzo, President and Chief Executive Officer of Cynapsus, stated: "We have been receiving requests for a more comprehensive, clinically based summary of apomorphine, covering its benefits, drawbacks and known side effects, as well as a summary of our development delivery candidate APL-130277-all in a single document. Accordingly, we have composed this background paper, which is now available on our website. It offers useful information to anyone who is interested in these topics."

The white paper is titled "Apomorphine for Off Periods in Parkinson`s Disease: Clinical Use and Potential of a Developmental Sublingual Formulation, APL-130277". It summarizes the medical literature on the freezing or "off" episodes experienced by 25 percent to 50 percent of Parkinson`s patients. It goes on to identify how apomorphine works as an acute intermittent rescue treatment. Further, it summarizes some of the most pertinent data from a recent survey of 500 neurologists worldwide regarding the number of patients who will potentially experience these "off" episodes. It then identifies past efforts to find new delivery methods and the benefits of the new APL-130277 sublingual approach. The paper reviews clinical data generated to date and further data expected through the remainder of 2013. It also includes predictions by the 500 neurologists regarding the potential use of the new delivery method by Parkinson`s patients who experience the "off" episodes.

A copy of the full paper is available at the Cynapsus website, http://www.cynapsus.ca

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About Cynapsus Therapeutics

Cynapsus is a specialty pharmaceutical company developing the only known orally administered (i.e. sublingual) delivery of the only approved drug (apomorphine) to be used as a rescue therapy for "off" motor symptoms of Parkinson`s disease. Apomorphine is currently primarily delivered as an inconvenient and painful subcutaneous injection. Over one million people in the U.S. and an estimated 5 million people globally suffer from Parkinson`s disease. Parkinson`s disease is a chronic and progressive neurodegenerative disease that impacts motor activity, and its prevalence is increasing with the aging of the population. Based on a recent study and the results of the Company`s Global 500 Neurologists Survey, it is estimated that between 25 percent and 50 percent of patients experience "off" episodes in which they have impaired movement or speaking capabilities. Current medications only control the disease`s symptoms, and most drugs become less effective over time as the disease progresses. Cynapsus` drug candidate, APL-130277, is an easy-to-administer, fast-acting reformulation of apomorphine, which is approved in an injection formulation to rescue patients from "off" episodes.

Cynapsus is focused on maximizing the value of APL-130277 by completing pivotal studies in advance of a New Drug Application expected to be submitted in 2015. Cynapsus anticipates a trade sale or out-licensing to an appropriate global pharmaceutical partner before such an application is submitted.

More information about Cynapsus (CTH:TSX-V) is available at http://www.cynapsus.ca and at the System for Electronic Document Analysis and Retrieval (SEDAR) at http://www.sedar.com.

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Cynapsus Therapeutics Inc. : Cynapsus Therapeutics Publishes White Paper on Apomorphine for 'Off' Periods in Parkinson ...