Drug showed promise in clearing drug-resistant tuberculosis

CHICAGO (Reuters) - An antibiotic used to treat severe bacterial infections showed promise at treating a highly drug-resistant and deadly form of tuberculosis, U.S. government and South Korean researchers said on Wednesday.

The study, published in the New England Journal of Medicine, is the first scientifically rigorous clinical trial of Pfizer's antibiotic linezolid, or Zyvox, in patients with extensively drug-resistant TB (XDR-TB), which is resistant to at least four of the drugs most often used to treat the lung infection.

Led by Clifton Barry of the National Institute of Allergy and Infectious Diseases and Sang-Nae Cho, professor of infectious diseases at Yonsei University, South Korea, the study showed the drug was effective when added to patients' current treatments.

"The data that were reported are rather impressive," Dr. Anthony Fauci, director of the institute, a part of the National Institutes of Health, said in a telephone interview.

However, most of the patients - 82 percent - experienced side effects while on the treatment, which tempered the findings, the team reported.

"That is the bad news," Fauci said. "The somewhat encouraging news is that despite the toxicity, when the drug dose was decreased or was temporarily discontinued, the toxic side effects diminished dramatically."

Researchers are desperately looking for new treatments for drug-resistant forms of TB, which threatens to derail progress in the global fight to eradicate the disease.

"To have a study that has a positive result, despite the fact that there are caveats, is an important advance in the right direction," Fauci said.

Treating typical TB cases is a long process, with patients needing to take a cocktail of powerful antibiotics for six months. Many patients fail to complete their treatment, a factor which has fueled a rise in the drug-resistant forms.

Although rare, 77 countries worldwide reported at least one case of XDR-TB by the end of 2011, according to the World Health Organization.

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Drug showed promise in clearing drug-resistant tuberculosis