E-Selectin Gene Haplotypes are Associated with the Risk of Myocardial Infarction – DocWire News

INTRODUCTION:

Endothelial dysfunction is one of the most important factors implicated in the pathogenesis of coronary artery disease (CAD). The aim of this study was to investigate the association of the E-selectin gene (SELE) with CAD and CAD-related traits using tagging polymorphisms.

A total of 379 Polish patients who had undergone angiography were included: 261 patients with angiographically documented CAD, 202 CAD patients withoutmyocardial infarction(CAD/MI(-) group) and 59 patients withmyocardial infarction(CAD/MI(+) group) as well as 118 healthy control subjects (non-CAD). Eight tagging single nucleotide polymorphisms (SNPs) in theSELEgene were selected using genotype data from HapMap. Genotyping was performed using PCR-RFLP and PCR-DHPLC methods.

The most commonSELEhaplotype in this analysis ([C;G;T;C;G;T], 31.2%) showed a negative association withmyocardial infarction(MI) (CAD/MI(+) vs. non-CAD) under the additive (p= 0.001), dominant (p= 0.006) and recessive (p= 0.012) model. Two other haplotypes ([C;G;C;C;A;C], [C;A;C;A;G;T], 5.73% and 18.1%, respectively) were also negatively associated with MI under the additive and dominant model. We also found two haplotypes ([T;G;T;C;G;T], [C;G;C;C;A;T], 1.52% and 6.71%, respectively) associated with the risk for MI (CAD/MI(+) vs. CAD/MI(-)), acting in both additive (p= 0.04,p= 0.007, respectively) and dominant (p= 0.04,p= 0.004, respectively) manner. There was no association with either CAD/MI(-) or with severity of CAD expressed as the number of vessels involved.

Our results suggest thatSELEis one of the independent genetic factors modifying the risk ofmyocardial infarction.

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E-Selectin Gene Haplotypes are Associated with the Risk of Myocardial Infarction - DocWire News