'Fat' drug could treat epilepsy

Posted: Published on November 22nd, 2012

This post was added by Dr Simmons

21 November 2012 Last updated at 09:02 ET

A substance made by the body when it uses fat as fuel could provide a new way of treating epilepsy, experts hope.

Researchers in London who have been carrying out preliminary tests of the fatty acid treatment, report their findings in Neuropharmacology journal.

They came up with the idea because of a special diet used by some children with severe, drug resistant epilepsy to help manage their condition.

The ketogenic diet is high in fat and low in carbohydrate.

The high fat, low carbohydrate diet is thought to mimic aspects of starvation by forcing the body to burn fats rather than carbohydrates.

The identification of these fatty acids is an exciting breakthrough

Although often effective, the diet has attracted criticism, as side-effects can be significant and potentially lead to constipation, hypoglycaemia, retarded growth and bone fractures.

By pinpointing fatty acids in the ketogenic diet that are effective in controlling epilepsy, researchers hope they can develop a pill for children and adults that could provide similar epilepsy control without the side-effects.

In early trials, the scientists, from Royal Holloway and University College London, say they have identified fatty acids that look like good candidates for the job.

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'Fat' drug could treat epilepsy

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