Funding From Alzheimer’s Drug Discovery Foundation Advances M3 Biotechnology Toward Human Trials – GlobeNewswire (press release)

April 13, 2017 20:00 ET | Source: M3 Biotechnology

SEATTLE, April 13, 2017 (GLOBE NEWSWIRE) -- As the first investor in M3 Biotechnology, the Alzheimers Drug Discovery Foundation (ADDF) helped validate the therapeutic potential of M3s drug candidate for Alzheimers disease. With a second investment of $1.4 million, the ADDF is now providing key funds to support the launch of human trials this year.

While current drugs for Alzheimers disease only provide symptomatic relief, M3s small molecule therapeutics have the potential to be truly disease-modifying. By re-establishing lost connections between brain cells, these therapies may halt the course of the disease. M3 is now in the process of planning a first-in-humans Phase 1a clinical trial for its lead candidate, NDX-1017, to evaluate its safety and determine optimal dosing range.

ADDFs first investment spurred others, including many private investors and Washington state-based venture groups W Fund and WRF Capital. These investments evidenced the faith in our potential, which helped us make it past the valley of death for drug development and raise nearly $14 million in additional funding, said Leen Kawas, M3s CEO.

The most noteworthy new investor in M3 is Dolby Family Ventures, which invests in technology and life sciences. The fund makes early stage investments in the most promising Alzheimer's-specific therapeutics which require funding for the critical phase of translating successful animal therapies to human clinical trials. The fund honors the late inventor, Ray Dolby, who died in 2013 and who lived with Alzheimer's disease.

The relationship with the ADDF has been vital to our progress as they have fostered a dynamic, collaborative biotech ecosystem, Kawas said. By providing early funding and connecting us with potential partners and investors, the ADDF has helped us reach the clinic.

Howard Fillit, MD, Founding Executive Director and Chief Science Officer of the ADDF, says, We are excited by the promising therapeutic approach of Dr. Kawas and her team at M3 Biotechnology. By helping neurons survive, NDX-1017 may restore cognitive function for Alzheimers patients. The ADDF looks forward to the results from this first human trial.

Alzheimers Drug Discovery Foundation (ADDF) Founded in 1998 by Leonard A. and Ronald S. Lauder, ADDF is dedicated to accelerating the discovery of drugs to prevent, treat and cure Alzheimers disease. The ADDF is a public charity solely focused on funding the development of drugs for Alzheimers, employing a venture philanthropy model to support research in academia and the biotech industry. Through the generosity of its donors, ADDF has awarded over $100 million to fund more than 500 Alzheimers programs in 18 countries.

M3 Biotechnology, Inc. M3 Biotechnology is a therapeutics company with a novel platform of disease-modifying regenerative small molecules, particularly relevant to neurodegenerative diseases like Alzheimers. M3s lead asset is being advanced as a first-in-class, disease-modifying treatment with the potential to restore lost connections between brain cells, turning degeneration into regeneration. Total financing of $14M to-date is used to prepare for and conduct Phase I clinical trials.

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Funding From Alzheimer's Drug Discovery Foundation Advances M3 Biotechnology Toward Human Trials - GlobeNewswire (press release)