InGen BioSciences Group, Exclusive Distributor for Cylex Incorporated in France, Reinforces its Translational Medicine …

CHILLY-MAZARIN, France, June 14, 2012 /PRNewswire/ --

InGen BioSciences, specialised in the development and commercialisation of mono and multiparametric in vitro diagnostic tests announced a new exclusive partnership with Cylex Incorporated (Columbia, Maryland, US), a global life sciences company focused on in vitro diagnostic products intended to illuminate immunity.

With this exclusive partnership with Cylex, InGen BioSciences will provide to the French medical community the only FDA-cleared, CE marked and IVDD compliant assay that detects changes in global immune function over time in patients undergoing immunosuppressive therapy for organ transplant: ImmuKnow.

Organ transplantation is an effective therapy for end-stage organ failure and is widely practised around the world. Global Observatory on Donation and Transplantation (GODT) 2010 data (produced by the WHO-ONT collaboration) report 106879 total solid organ transplants per year of which 73179 kidney transplants , 21 602 liver transplants and 5 582 heart transplants(1).

Studies show that long-term use of immunosuppressants is associated with significant morbidity and mortality in transplant recipients and current monitoring systems of immunosuppression in those patients are typically focused on prevention of clinical toxicities of immunosuppressive drugs. Minimising the risk of infection and rejection in post-transplant patients is therefore crucial and challenging for clinicians.(2-5) Unfortunately, these strategies are often not tailored to the individual and do not determine the optimal level of immunosuppression for these patients.(3)

ImmuKnow, is an innovative platform, using a small blood sample, to simply and reproducibly assess immune cell function, providing medical professionals with crucial insight for individualised allograft transplant patient management allowing them to better tailor immunosuppressant drug regimens to prevent organ rejection while avoiding infection.

"Cylex is a global life sciences company leading in vitro diagnostic assays that measure cellular immune function and ImmuKnow is an established, accepted technology that is critical to providing better patient care" says Brad L. Stewart, President and CEO of Cylex. "This distribution partnership with InGen BioSciences represents an exciting opportunity for offering the best possible services to French transplant professionals seeking to provide individualised management for their patients."

"We are very proud of this exclusive partnership with Cylex which reinforces our innovative offerings in immunology, complements our HLA IVD portfolio and strengthens our positioning in integrated, concrete best-in-class solutions for present and future needs of healthcare professionals in the rapidly evolving field of diagnostics", comments Isabelle Buckle, CEO of InGen BioSciences. "With our partners ONE LAMBDA and now CYLEX, we respond to transplant specialists needs of diagnostic tools for assessing donor-recipient matching as well as a personalised monitoring of transplanted patients."

Since its foundation in 2001, InGen BioSciences has experienced 19 percent compound growth (CAGR) and counts 65 employees (of whom 15% are dedicated to R&D). Its first proprietary product, BJI InoPlex, a non-invasive and easy to use tool for detection of infections in pre-and post-operative implants for orthopaedic surgeons, infectious diseases specialists and other healthcare professionals, was launched in 2011.

1. 2010 Estimates from the Global Observatory on Donation and Transplantation. http://www.transplant-observatory.org/Pages/Uses-of-Data.aspx last visited May 30th 2012. 2.FishmanJ A. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357:2601-2614.. 3. Cainelli F., Vento S. Infections and solid organ transplant rejection: a cause-and-effect relationship? The Lancet Infectious Diseases,2002 ; 2: Issue 9, : 539-549 4. Kowalski, R J.; Post, Diane R.; Mannon, Roslyn B. et al. Assessing Relative Risks of Infection and Rejection: A Meta-analysis using an Immune Function Assay. Transplantation 2006 ; 82 - Issue 5: 663-668. 5. Cabrera R, Ararat M, Soldevila-Pico C, et al. Using an immune functional assay to differentiate acute cellular rejection from recurrent hepatitis C in liver transplant patients. Liver Transpl. 2009;15:216- 222.

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InGen BioSciences Group, Exclusive Distributor for Cylex Incorporated in France, Reinforces its Translational Medicine ...