New York Stem Cell Foundation announces partnership with Parkinson's Progression Markers Initiative

Public release date: 15-Oct-2013 [ | E-mail | Share ]

Contact: David McKeon dmckeon@nyscf.org 212-365-7440 New York Stem Cell Foundation

NEW YORK, NY (October 15, 2013) The New York Stem Cell Foundation (NYSCF) Research Institute has entered into a partnership with the Parkinson's Progression Markers Initiative (PPMI) to build resources for studying Parkinson's disease to accelerate new treatments. Sponsored by The Michael J. Fox Foundation for Parkinson's Research, PPMI is a landmark effort to identify and validate biomarkers of Parkinson's disease. The study is currently under way at 32 clinical sites worldwide with funding from 13 industry partners.

NYSCF will generate stem cell lines from PPMI participants, allowing researchers to examine how Parkinson's disease develops in and progresses in a large and genetically diverse group of patients. This research could potentially lead to the development of treatments tailored to different subtypes of PD. To accelerate discovery and drug development, these stem cell lines will be made available, with de-identified patient data, to the scientific community at large.

"To prevent or slow the progression of Parkinson's disease, we need to elucidate the pathobiology of PD," said Ken Marek, PhD, principal investigator of PPMI and senior scientist and co-founder of the Institute for Neurodegenerative Disorders. "The cell lines generated by The New York Stem Cell Foundation will be an important tool to help us understand the etiology and progression of PD in combination with the comprehensive biomarker data already coming from PPMI."

Lawrence E. Golub and Karen L. Finerman have committed to fund the first phase of this partnership. The couple previously funded the NYSCF Golub Stem Cell Research Initiative for Parkinson's Disease Research, which provided a basis for the collaboration. Golub and Finerman are both members of the NYSCF Leadership Council and Finerman also serves on the Michael J. Fox Foundation Board of Directors.

Pursuit of Parkinson's Biomarkers

PPMI is a long-term, observational study that tracks the progression of PD to identify biomarkers: biological substances, processes or characteristics associated with the risk, presence and/or progression of disease. The study completed initial recruitment of 400 PD patients and 200 healthy, age and gender-matched controls in early 2013. Participants undergo longitudinal imaging, clinical and biological tests over five years, and, since its inception, PPMI has offered all qualified investigators real-time access to that de-identified data through an online database. In addition to the initial cohort of 600, PPMI has expanded to enroll individuals without PD but with known risk factors smell loss, REM sleep behavior disorder and certain genetic mutations to characterize biomarkers before the onset of motor symptoms.

"We are very excited to be a part of this joint effort with the Parkinson's Progression Markers Initiative. This collaboration will provide a comprehensive look at this devastating disease at the cellular level across a broad number of patients," said Susan L. Solomon, Chief Executive Officer of NYSCF. "We are very grateful to Lawrence Golub and Karen Finerman for their pioneering support of the NYSCF Golub Stem Cell Research Initiative for Parkinson's Disease Research."

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New York Stem Cell Foundation announces partnership with Parkinson's Progression Markers Initiative