For a study, researchers came up with the idea that reclassifying people who subsequently suffer from myocardial infarction and ischemic heart disease would be reasonable, given the inclusion of high residual cholesterol. They monitored 41,928 white Danish people from the Copenhagen General Population Study for more than ten years who had no prior history of ischemic cardiovascular disease, diabetes, or statin usage. Continue reading →

In 1980, while studying coronary anatomy in medical school, I learned that a heart attack involving the left anterior descending artery was nicknamed the "widow-maker." I thought this was a clever term because it emphasized the importance of this artery, the occlusion of which carries a high risk for death. Continue reading →

Objective To delineate the differences in demographic characteristics and hospitalization outcomes in patients with acute myocardial infarction by comorbid acute kidney injury (AKI) and to explore the risk factors for in-hospital mortality due to AKI in acute myocardial infarction (AMI) inpatients. Continue reading →

Introduction Cardiac fibrosis is a common pathological feature of several cardiovascular diseases, leading to increased stiffness of the ventricular wall and impaired cardiac function.13 Inflammation is a crucial factor in cardiac fibrosis.4 Ischemia, hypoxia, and metabolic changes resulting from multiple causes lead to the infiltration of inflammatory cells and elevated levels of pro-inflammatory cytokines and chemokines.4,5 Interactions with damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns(PAMPs) can lead to activation and oligomerization of NLRP3 followed by recruitment of the apoptotic speck protein containing a caspase recruitment domain (ASC) and pro-caspase-1.6,7 The activated caspase-1 subsequently cleaves pro-IL-1 and pro-IL-18 to yield mature IL-1 and IL-18. In addition, caspase-1 triggers pyroptosis by cleaving Gasdermin D (GSDMD), resulting in the binding of the GSDMD N-terminal domain to phospholipids in the cell membrane, forming a GSDMD pore.8,9 NLRP3 is an important mediator of both autoimmunity and myocardial fibrosis.1012 Therefore, elucidating the mechanism by which the NLRP3 inflammasome influences cardiac fibrosis and summarizing potential treatments for targeting the inflammasome may suggest promising therapeutic strategies for the prevention and treatment of cardiac fibrosis. The inflammatory response is a normal physiological activity of the body in response to the invasion of external pathogenic microorganisms.13 The inflammasome plays a key r role in the inflammatory response.14,15 Five primary inflammasomes are currently known; these include the NLRP1, NLRP3, NLRC4, IPAF, and AIM2 inflammasomes Continue reading →

In a nationwide cohort, researchers wanted to see how AF affected the risk of adverse outcomes after noncardiac surgery. From 2015 to 2019, they identified Medicare members hospitalized for noncardiac surgery and separated the study cohort into two groups: those with and without AF. Noncardiac surgery was divided into the following categories: vascular, thoracic, general, genitourinary, gynecological, orthopedics and neurosurgery, breast, head and neck, and transplant Continue reading →

We need cholesterol for our overall health, but too much is a bad thing. High cholesterol can cause major health problems and is called a silent killer because there's often no warning signs. While high cholesterol can be inherited, lifestyle choices like poor diet, lack of exercise and smoking can increase the risk. Continue reading →

New research from an analysis of trends in the cardiovascular health of US adults from 1999-2018 is drawing attention to concerning trends related to cardiometabolic health across the nation. Continue reading →

Objective To provide clinicians and patients with accurate risk estimates of serious adverse events after common elective shoulder arthroscopic procedures, including reoperation within one year. Design Population based cohort study. Setting Hospital Episode Statistics for NHS England, including civil registration mortality data from the Office for National Statistics. Continue reading →

Darroudi, S. et al. Prevalence of combined and noncombined dyslipidemia in an Iranian population. Continue reading →

Global Biomaterials Market Size is estimated to be worth USD 285.6 billion by 2026, with a CAGR of 14.5% over the projected period, according to Acumen Research & Consulting In recent years, the use of biomaterials in healthcare has significantly increased. Continuously growing government grants and financing for the development of novel and innovative biomaterials, expanding developments in medical implant materials, and the increasing prevalence of cardiovascular and orthopedic disorders, as well as expanded research on regenerative medicine, are driving the global market expansion. Continue reading →