Stroke patients whose blocked arteries are re-opened with surgical devices fared better in a study than those treated with intravenous drugs alone to dissolve clots, offering the first solid evidence of an effective new treatment. In a trial of 500 Dutch patients with stroke caused by lack of blood flow in the brain, 33 percent had little or no disability 90 days after receiving the direct intervention, compared with 19 percent in the control group, according to an article published today in the New England Journal of Medicine. There was no increased risk of death following the treatments. Stroke is the fourth-leading cause of death in the U.S., killing almost 130,000 a year, according to the Centers for Disease Control and Prevention. The standard treatment for patients with ischemic stroke -- those caused by a blocked blood vessel instead of a hemorrhage -- has been limited to enzymes that dissolve clots administered intravenously, and is only effective in the first four and half hours after a stroke. While some doctors have treated the blockage directly, until now there have been no conclusive studies showing that works. The Dutch trial - called MR CLEAN, for Multicenter Randomized Clinical Trial of Endovascular … Continue reading
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