Introduction AP is a rapid onset of abdominal inflammation, which is the most common gastrointestinal cause of hospitalization or death in China and many other countries. Continue reading →

This article was originally published here FASEB J. 2021 Aug;35(8):e21761. doi: 10.1096/fj.202100746R. Continue reading →

Jul 18, 2021 at 12:01 CEST That Artificial intelligence it is going to modify, and in fact it is already modifying, the world as we know it, it is a reality. Deep Learning, Machine learning& mldr; state-of-the-art technology that also finds its way into multiple branches of science and medicine Continue reading →

Introduction Fibroblast growth factors (FGFs) are widely expressed in the human body and have numerous and complicated physiological functions. FGFs regulate cell growth, proliferation, differentiation, and metabolic modulation, tissue repair, and inflammatory response.1,2 FGFs can be divided into three types (classic, intracellular and hormone-like types) based on their action modes.3 Classic and intracellular FGFs mostly act in an autocrine or paracrine way,4 while hormone-like FGFs mainly act in the endocrine way.5 Most autocrine and paracrine FGFs have a high affinity for the heparin glucosamine sulfate (HSGAG), which promotes the binding of the FGFs to the tyrosine kinase FGF receptor (FGFR1-4) on the cell surface, inducing FGFR activation, dimerization, and activation of downstream signaling pathways.69 HSGAGs can also stabilize FGFs, prevent FGFs degradation, and limit the diffusion range of FGFs.10 FGF21 is a member of the FGF19 subfamily in the FGFs family and belongs to the hormone-like FGFs. Compared to other FGFs members, FGF21 has three special features: 1. Continue reading →