By Deborah Borfitz January 27, 2021 | An intracellular signaling network known as the integrated stress response (ISR) is of growing interest to drug developers because it seems to be affecting so many clinical conditions, ranging from Down syndrome and traumatic brain injury (TBI) to hearing loss, some types of prostate cancer, and the natural process of aging, according to Susanna Rosi, Ph.D., director of neurocognitive research in the UCSF Brain and Spinal Injury Center. The original study in PNAS (DOI: 10.1073/pnas.1707661114) showing that ISR inhibition reverses cognitive deficits after TBI was conducted in the Rosi lab at the University of California, San Francisco, where she is a professor in the departments of neurological surgery and physical therapy and rehabilitation science. The next logical step was to see if the same approach could undo age-related cognitive decline, which indeed it could and in a matter of daysat least in mice Continue reading →

Two-time Stanley Cup winner Daniel Carcillo is the co-founder and CEO of Wesana Health, a company ... [+] that recently raised $4 million to fund clinical trials and drug development focusing on traumatic brain injury and psilocybin Continue reading →

Your eyes are capable of moving in many directions to view and track things in your environment. These movements are usually voluntary, but there can be times when your eyes move involuntarily, too. Its possible that some health conditions may cause your eyes to move involuntarily in a specific way. Continue reading →

Veterans are sought to participate in a Veterans Affairs research study on factors that contribute to headaches and neck pain in veterans with mild traumatic brain injury, aka TBI. Results of the study are intended to help researchers better understand the reasons for headaches and neck pain after TBI and may lead to improved treatment. The study is open to veterans ages 18-55 who have had TBI. Continue reading →

Growth hormone deficiency (GHD) is a rare condition. It can be congenital (present from birth), or a person can acquire it during childhood or adulthood Continue reading →

The size of your pupils can say a lot about your health and your state of mind. Continue reading →

Blood clots are a normal part of your bodys response to injury. When you cut yourself, cell fragments called platelets rush to the injury site to seal up the damage and stop the bleeding. Other blood clots arent helpful. Continue reading →

Newswise (Baltimore, MD) Mercy Medical Center, Baltimore, MD has performed its first TransCarotid Artery Revascularization (TCAR) procedure this week, a clinically proven, minimally invasive and safe approach for high surgical risk patients who need carotid artery treatment. Mercy vascular surgeons Drs Continue reading →

Jan 25, 2021 Emily KaplanESPN Emily Kaplan is ESPN's national NHL reporter. Dylan Larkin has a hard time sugar-coating it -- last season sucked for him and the Detroit Red Wings. It's tough to finish with a minus-122 goal differential and 23 fewer points than any other team Continue reading →