A chance discovery of a beautifully preserved fossil in the desert landscape of Morocco has solved one of the great mysteries of biology and palaeontology: how starfish evolved their arms. Starfish are one of the most recognisable animals on our planet. Most people probably associate them with trips to the beach, walking in rock pools or swimming in the sea. Continue reading →

Ezra Anpo (right), here with his sister Aria, participated in a research study investigating a liquid biopsy approach to providing a genetic diagnosis in children with lymphatic malformations. Doctors at Seattle Childrens are investigating whether a simple liquid biopsy containing a small amount of fluid from a patient may someday provide an easier route to a genetic diagnosis in children with vascular or lymphatic malformations. Continue reading →

High-dose personalized dosimetry treatment with Yttrium-90 (Y-90) glass microspheres (TheraSphere) is a promising local therapy for patients with advanced hepatocellular carcinoma (HCC), said Beau Toskich, MD, who added that findings from the phase 2 DOSISPHERE-01 trial provide clinical evidence in support of the therapy as an ablative strategy. Y-90 can control liver disease to enable us to give the patient the benefit of the doubt when it comes to their tumor biology, said Toskich. Just because [a tumor] looks a certain way, doesnt mean that it will behave a certain way. Continue reading →

Introduction Diabetic nephropathy, now commonly recognized as diabetic kidney disease (DKD), occurs in diabetic patients, especially those with poor long-term glycemic control,1 causing high morbidity and risk of death. As lifestyles and diets have changed in recent years, the global incidence of diabetes mellitus (DM) has increased annually, as reported by the International Diabetes Federation, which estimates that the incidence of diabetes mellitus (DM) will increase to 700 million in 2045.2 Consequently, diabetic kidney disease will increase social financial costs and threaten human health. DKD is defined by changes in the structure and function of the kidneys Continue reading →

Abstract Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. Continue reading →

A chance discovery of a beautifully preserved fossil in the desert landscape of Morocco has solved one of the great mysteries of biology and palaeontology: how starfish evolved their arms. Starfish are one of the most recognisable animals on our planet. Continue reading →