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UC Davis gets $53 million in stem cell funds to study Huntington's, other diseases

Posted: Published on July 27th, 2012

The University of California, Davis, scored a major coup in stem cell funding with a $53 million award Thursday for research into Huntington's disease, limb ischemia and osteoporosis. The grants were approved Thursday afternoon by CIRM the California Institute for Regenerative Medicine. They are a major milestone for the university, which had received $73 million in past funding from the state agency. "We're here to bring this new era of medicine to patients," UC Davis stem cell program director Jan Nolta said. For Melissa Biliardi of Santa Maria, the vote symbolizes hope. Her son, James Birdsall, 32, was diagnosed four years ago with Huntington's disease. The degenerative brain disorder could prove fatal over the next 10 to 15 years. There is currently no cure or treatment, but with the grant, UC Davis researchers hope to deliver an effective therapy in four years. "This is the most hope we've ever had for a cure or treatment," Biliardi said. Her son suffers from involuntary movement and fatigue, all symptoms of the disease, and relies on a wheelchair to get around. Birdsall is one of 30,000 Americans living with the genetic disorder, according to Nolta. Another 150,000 are at risk, but many aren't … Continue reading

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Malaya Business Insight

Posted: Published on July 27th, 2012

Details Published on Friday, 27 July 2012 00:00 STEM cell therapy is being eyed to cure the neck and back pains and other illnesses of former president and now Pampanga Rep. Gloria Arroyo, alternative medicine doctor Antonia Park said yesterday. Arroyo went to Parks Green and Young Health and Wellness Center in Tagaytay City yesterday morning for cleansing and alternative healing. A guard at the La Vista Subdivision in Quezon City, who requested anonymity, said Arroyo left the subdivision at around 7:30 a.m., accompanied by a few staff and a personal nurse. She rode a white Nissan Patrol and her convoy included a gray Toyota Land Cruiser and a police escort. Arroyo was granted bail Wednesday by a Pasay City court after finding that the electoral sabotage case against her was weak. She posted a P1-million cash bond. Stem cell treatment involves the introduction of new adult stem cells into the damaged tissue in order to treat a disease or injury. The ability of new cells to regenerate is seen as having significant potential to replace diseased areas of the body, with minimal risk of rejection and side effects. Park, in a statement distributed to the media, said Arroyo complained … Continue reading

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Arroyo might undergo stem cell therapy

Posted: Published on July 27th, 2012

MANILA, Philippines - Former President Gloria Macapagal-Arroyo might undergo stem cell therapy to improve her health, according to the alternative medicine facility in Tagaytay City that the Pampanga lawmaker visited Thursday. Arroyo came to the facility complaining of difficulty in swallowing because of a bulge in her throat, according to a statement from the Green 8 Young Health & Wellness Center. Her voice has also changed and she is losing weight because she can't swallow solid food. She also has angina, the center said. Arroyo also complained of continuing neck and back pain. "Our center is accepting her for possible stem cell therapy," the alternative medicine facility said. "The stem cell therapy is... strongly considered." It said the Arroyo can undergo such therapy in the Tagaytay center while her physical therapy will continue at the Veterans Memorial Medical Center 4 times a week. The Pampanga lawmaker is seeking treatment at the center through her sister, Cielo Macapagal-Salgado. The center said Salgado was previously diagnosed with a cancerous lump in her breast. "She consulted several doctors and was subsequently subjected to a myrad of treatment procedures. These, however, did not produce the desired results. When she came to our center she … Continue reading

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Researchers Mark Progress in Reprogramming Skin Cells Into Heart Muscle Cells

Posted: Published on July 27th, 2012

HOUSTON--(BUSINESS WIRE)-- Physicians and scientists at the Texas Heart Institute (THI) at St. Lukes Episcopal Hospital, working collaboratively with the University of Houston (UH), Texas A&M Health Science Center in Houston and Baylor College of Medicine, have shown a new way to convert human skin cells into beating heart cells, according to an article being published in the prestigious Proceedings of the National Academy of Sciences of the United States of America (PNAS). Researchers believe this is to be an important new and unique step toward being able to repair damage from heart attacks in human hearts, which on their own have very little regenerative capabilities. The team, led by Robert J. Schwartz, PhD, director of Stem Cell Engineering at THI and director of UHs Center for Molecular Medicine and Experimental Therapeutics, used human skin cells called fibroblasts, and treated them with ETS2 and MESP1, two human genetic transcription factors that play important roles in the genetic network that produces cardiovascular tissues. The skin cells were converted into progenitors of cardiomyocytes - beating heart muscle cells - within a period of weeks. Progenitors can differentiate to form one or more kinds of cells. Dr. Schwartz explains: "Our study showed that … Continue reading

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CUR – Hope In Neurodegenerative Diseases

Posted: Published on July 27th, 2012

By Jason Napodano, CFA Last month we published a NOTE outlining the pioneering efforts of Neuralstem (NYSE MKT:CUR) in the use ofhuman neural stem cells ("hNSC") for the treatment of central nervous system diseases and neurodegenerative disorders.Neuralstems lead development program is for Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrigs disease, named after the famous New York Yankee first baseman who was diagnosed with the disease in 1939, and passed in 1941 at the age of only 37. The hippocampus is critically important to the control of memory and is severely impacted by the pathology of AD.Specifically, hippocampal synaptic density is reduced in AD and correlates with memory loss.Cam/Tet-DT mice mimic the substantial loss of hippocampal neurons that occur in advanced AD. StemCells Inc's data shows that one month after transplantation, HcCNS-SC engraft, migrate locally, and have begun to differentiate into neuronal and glial lineages in both models. This resulted in observed increased synaptic density and improved memory post transplantation. Importantly, these results did not require reduction in beta amyloid or tau that accumulate in the brains of patients with AD and account for the pathological hallmarks of the disease, suggesting a new mechanism of action for the treatment … Continue reading

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Malaya Business Insight

Posted: Published on July 27th, 2012

Details Published on Friday, 27 July 2012 00:00 STEM cell therapy is being eyed to cure the neck and back pains and other illnesses of former president and now Pampanga Rep. Gloria Arroyo, alternative medicine doctor Antonia Park said yesterday. Arroyo went to Parks Green and Young Health and Wellness Center in Tagaytay City yesterday morning for cleansing and alternative healing. A guard at the La Vista Subdivision in Quezon City, who requested anonymity, said Arroyo left the subdivision at around 7:30 a.m., accompanied by a few staff and a personal nurse. She rode a white Nissan Patrol and her convoy included a gray Toyota Land Cruiser and a police escort. Arroyo was granted bail Wednesday by a Pasay City court after finding that the electoral sabotage case against her was weak. She posted a P1-million cash bond. Stem cell treatment involves the introduction of new adult stem cells into the damaged tissue in order to treat a disease or injury. The ability of new cells to regenerate is seen as having significant potential to replace diseased areas of the body, with minimal risk of rejection and side effects. Park, in a statement distributed to the media, said Arroyo complained … Continue reading

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Potential anti-obesity drug developed

Posted: Published on July 27th, 2012

SCIENTISTS believe they may have found the right recipe for an obesity drug to help people lose weight and keep it off, without nasty side effects. The drug, which is yet to be tested in humans, increases sensitivity to the body's appetite-suppressant hormone, leptin. "By sensitising the body to naturally occurring leptin, the new drug could not only promote weight loss, but also help maintain it," said study author George Kunos of the National Institute on Alcohol Abuse and Alcoholism in the US. The drug works by reversing desensitisation to leptin, a process scientists think is caused by receptors that mediate hunger sparked by marijuana use and naturally occurring cannabinoids in the body. Scientists have previously developed anti-obesity drugs to target cannabinoid receptor type 1 (CB1R), but one, rimonabant, was taken off the market in Europe because of serious side effects including anxiety, depression and suicidal thoughts. Dr Kunos and his team minimised the side effects by developing a drug that targets CB1R without entering the brain. Obese mice given the drug lost weight after their appetites were suppressed by increasing their sensitivity to leptin. The mice did not express anxiety or adverse behavioural side effects. "Obesity is a growing … Continue reading

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'Jersey Shore's The Situation on rehab stint: 'I hit rock bottom'

Posted: Published on July 27th, 2012

Mike 'The Situation' Sorrentino has admitted that he hit rock bottom before his recent trip to rehab. The Situation emerged from his rehab stint for prescription drug and alcohol dependency in April, with his representative insisting that the star was "stronger and better than ever". In an interview with In Touch, the Jersey Shore cast member revealed that his painkiller addiction was so severe that he once considered turning down a $40,000 personal appearance. "I didn't even care... When you're dependent on a substance, it's the only thing that matters," he recalled. The Situation did make the personal appearance in Australia, but was soon confronted by his family about his drug use. "On the plane home, they said, 'Mike, you've got to handle this now'. I knew that they were right, that if I didn't fix the problem there'd be no Situation," the reality star said. He also said: "[I remember thinking] 'Am I going to be that guy that was so awesome on the Jersey Shore and then... that's it?" The Situation admitted in May that completing rehab initially seemed "impossible", but insisted that the process helped him get to "a good place". Earlier this week, it was reported … Continue reading

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Modeling of new enzymes helps develop therapies for cocaine abuse

Posted: Published on July 27th, 2012

ScienceDaily (July 26, 2012) Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the treatment of drug dependency. The results of this study by Chang-Guo Zhan et al are published in the journal PLOS Computational Biology. The effectiveness of the enzymes' work was evaluated through modeling cocaine pharmacokinetics, the study of the body's action on administered external substances, such as cocaine, when the enzyme exists in the body. As there is no FDA-approved anti-cocaine medication, the medical and social consequences of cocaine abuse have made the development of anti-cocaine medication a high priority. Administration of an enzyme to enhance cocaine metabolism has been recognized as a promising treatment strategy for overdose and abuse. A remarkable feature of the enzyme-based therapeutic approach is that one enzyme molecule can degrade many thousands of drug molecules per minute. This pharmacokinetic modelling is a crucial step of enzyme-based therapy development for cocaine abuse. Furthermore, the general insights of the research should also be valuable for future development of an enzyme therapy for any addictive drug, as the … Continue reading

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The modeling of new enzymes helps develop therapies for cocaine abuse

Posted: Published on July 27th, 2012

Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the treatment of drug dependency. The results of this study by Chang-Guo Zhan et al are published in the journal PLOS Computational Biology. The effectiveness of the enzymes' work was evaluated through modeling cocaine pharmacokinetics, the study of the body's action on administered external substances, such as cocaine, when the enzyme exists in the body. As there is no FDA-approved anti-cocaine medication, the medical and social consequences of cocaine abuse have made the development of anti-cocaine medication a high priority. Administration of an enzyme to enhance cocaine metabolism has been recognized as a promising treatment strategy for overdose and abuse. A remarkable feature of the enzyme-based therapeutic approach is that one enzyme molecule can degrade many thousands of drug molecules per minute. This pharmacokinetic modelling is a crucial step of enzyme-based therapy development for cocaine abuse. Furthermore, the general insights of the research should also be valuable for future development of an enzyme therapy for any addictive drug, as the general methodology of the … Continue reading

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