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Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study : The Lancet

Posted: Published on July 26th, 2012

Background Stem-cell-based, tissue engineered transplants might offer new therapeutic options for patients, including children, with failing organs. The reported replacement of an adult airway using stem cells on a biological scaffold with good results at 6 months supports this view. We describe the case of a child who received a stem-cell-based tracheal replacement and report findings after 2 years of follow-up. A 12-year-old boy was born with long-segment congenital tracheal stenosis and pulmonary sling. His airway had been maintained by metal stents, but, after failure, a cadaveric donor tracheal scaffold was decellularised. After a short course of granulocyte colony stimulating factor, bone marrow mesenchymal stem cells were retrieved preoperatively and seeded onto the scaffold, with patches of autologous epithelium. Topical human recombinant erythropoietin was applied to encourage angiogenesis, and transforming growth factor to support chondrogenesis. Intravenous human recombinant erythropoietin was continued postoperatively. Outcomes were survival, morbidity, endoscopic appearance, cytology and proteomics of brushings, and peripheral blood counts. The graft revascularised within 1 week after surgery. A strong neutrophil response was noted locally for the first 8 weeks after surgery, which generated luminal DNA neutrophil extracellular traps. Cytological evidence of restoration of the epithelium was not evident until 1 year. The … Continue reading

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Gov. Beshear signs order to regulate prescriptions

Posted: Published on July 25th, 2012

FRANKFORT, Ky. - Kentucky Gov. Steve Beshear has signed emergency regulations that require doctors to meet tougher prescription standards in an effort to stop drug abuse. The rules, which were given to given to state boards that oversee the medical industry on Friday, were presented to lawmakers Monday and will remain in effect until permanent regulations are adopted. The Courier-Journal reports that under the order, pain clinics will face more regulations and doctors are required to use the state's prescription drug tracking system. Some physicians have raised concerns that the order exceeds the original goal of a bill passed by lawmakers, but Beshear said in a prepared statement that his office worked diligently to make sure the emergency regulations match the intent of the bill. "Everyone's ultimate goal is to reduce the abuse and diversion of prescription drugs, and these regulations are a necessary step in effecting that change," he said. "The regulations are built to protect legitimate patient needs and proper prescribing habits. Only those who abuse the system have anything to fear." The statute passed by lawmakers didn't spell out new regulations. Instead, it said licensing boards should "police their own industry" and gave them until Sept. 1 … Continue reading

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Ask the GAL: Readers respond on how to help children in dependency

Posted: Published on July 25th, 2012

Last week I asked you to respond to the question: What can we, as a community or individually, do to help children in dependency? I want to share with you some excerpts of the 60 responses I received. A: Individually I think we all have to be more vigilant and get involved when it comes to children. When we see abuse, I think it is our duty to get involved. As a society, I think the pharmaceutical companies should somehow bear the cost of taking care of some of these children born addicted to drugs. I know this is a stretch, but prescription drugs are responsible for so many problems that we, as a society, are going to have to pay for. I would love to start a class action law suit for every child in dependency because of prescription drugs. -- Robert Hupalo A: As a community, we can advocate to ensure that the medical profession, pharmacies and drug manufacturers are held accountable for any indiscriminate use of painkillers, in order to reduce criminal activity and the addictions that can lead to neglect of children. -- Donna Townsend A: Establish a local transportation service dedicated to dependent children. -- … Continue reading

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'Bath salts' ban may do little to curb new drugs

Posted: Published on July 25th, 2012

WASHINGTON People are inventing so many new ways to get high that lawmakers can't seem to keep up. Over the past two years, the U.S. has seen a surge in the use of synthetic drugs made of legal chemicals that mimic the dangerous effects of cocaine, amphetamines and other illegal stimulants. The drugs are often sold at small, independent stores in misleading packaging that suggests common household items like bath salts, incense and plant food. But the substances inside are powerful, mind-altering drugs that have been linked to bizarre and violent behavior across the country. Law enforcement officials refer to the drugs collectively as "bath salts," though they have nothing in common with the fragrant toiletries used to moisturize skin. President Barack Obama signed a bill into law earlier this month that bans the sale, production and possession of more than two dozen of the most common bath salt drugs. But health professionals say lawmakers cannot keep pace with bath salt producers, who constantly adjust their chemical formulations to come up with new synthetic drugs that aren't covered by new laws. Experts who have studied the problem estimate there are more than 100 different bath salt chemicals in circulation. "The … Continue reading

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'Bath salts' ban: Many drugs remain legal

Posted: Published on July 25th, 2012

July 25, 2012 By MATTHEW PERRONE, AP Health Writer WASHINGTON (AP) -- People are inventing so many new ways to get high that lawmakers can't seem to keep up. Over the past two years, the U.S. has seen a surge in the use of synthetic drugs made of legal chemicals that mimic the dangerous effects of cocaine, amphetamines and other illegal stimulants. The drugs are often sold at small, independent stores in misleading packaging that suggests common household items like bath salts, incense and plant food. But the substances inside are powerful, mind-altering drugs that have been linked to bizarre and violent behavior across the country. Law enforcement officials refer to the drugs collectively as "bath salts," though they have nothing in common with the fragrant toiletries used to moisturize skin. President Barack Obama signed a bill into law earlier this month that bans the sale, production and possession of more than two dozen of the most common bath salt drugs. But health professionals say lawmakers cannot keep pace with bath salt producers, who constantly adjust their chemical formulations to come up with new synthetic drugs that aren't covered by new laws. Experts who have studied the problem estimate there … Continue reading

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Many synthetic drugs still legal after "bath salts" ban

Posted: Published on July 25th, 2012

(AP) WASHINGTON - People are inventing so many new, legal ways to get high that lawmakers can't seem to keep up. Over the past two years, the U.S. has seen a surge in the use of synthetic drugs made of legal chemicals that mimic the dangerous effects of cocaine, amphetamines and other illegal stimulants. The drugs are often sold at small, independent stores in misleading packaging that suggests common household items like bath salts, incense and plant food. But the substances inside are powerful, mind-altering drugs that have been linked to bizarre and violent behavior across the country. Law enforcement officials refer to the drugs collectively as "bath salts," though they have nothing in common with the fragrant toiletries used to moisturize skin. DEA to outlaw "bath salt drugs" "Bath salts" have effects similar to meth, ecstasy Products considered synthetic drugs. President Barack Obama signed a bill into law earlier this month that bans the sale, production and possession of more than two dozen of the most common bath salt drugs. But health professionals say that there are so many different varieties of the drugs that U.S. lawmakers are merely playing catch up. "The moment you start to regulate one … Continue reading

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Assurances given over new pharmacy planned for Workington housing estate

Posted: Published on July 25th, 2012

By Karen Evans Last updated at 12:47, Wednesday, 25 July 2012 A pharmacy which will take over Mills Papershop in the Moorclose shopping precinct in Workington will only service drug users from that area with a methadone service, its owners have said. Saeed Ltd Chemist chain, which will transform the papershop on Westfield Drive, reassured residents at a Neighbourhood Forum meeting last night that drug users would be supervised when taking their prescription on site. Zubair Malik, partner of the chain, said that they would be taken into a private consultation area within the chemist to take their medication. He added that any trouble would be reported to the NHS where users medication would be stopped or they would be asked to attend another pharmacy to take their medication. In June residents raised concerns that the service would lead to drug users congregating outside and causing a nuisance when they came to collect their medication. Mr Malik said: I will treat those patients with the same level of respect as I treat all my patients. I want to help those people and to help them move forward with their lives and offering this service will help them do this. The … Continue reading

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Pharmacy relocation

Posted: Published on July 25th, 2012

The anticipated other shoe dropped this week when Big Y Foods announced it will be closing its pharmacy at 2 Bank St. in New Milford and consolidating its services at the Big Y store across the Housatonic River. That move will mark the end of an era for downtown New Milford and will herald a new era of opportunity for the downtown business community. When Big Y bought the pharmacy -- then called the New Milford Pharmacy -- from the Salisbury Pharmacy Group a year and a half ago, many residents and town officials predicted it wouldn't be long before Big Y consolidated its two stores. They were right. And when local businessman Gary Goldring bought the building last month, the handwriting was on the wall for Big Y's imminent departure from the Village Green. The move, scheduled for August, will leave the village center without a pharmacy for the first time in memory. For decades, two mom-and-pop stores -- the Slone Pharmacy at the head of Bank Street and Lautier's Pharmacy at the foot of the street served the community. And after Lautier's closed, CVS provided a second pharmacy in the heart of the village center until it moved … Continue reading

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Pharmacy professor gets fellowship

Posted: Published on July 25th, 2012

Professor Kevin Garey of the UH College of Pharmacy was awarded an American Society of Health-System Pharmacists fellowship this summer during the ASHP Summer Meeting and exhibition June 12. ASHP fellows are recognized as those who have made significant contributions to scientific literature, research and education. It just shows that youve done a lot of important work for this large organization, for ASHP, Garey said. Its a nice thing for me personally and then a great thing for the University of Houston and then Houston in general. ASHP is a professional organization that represents pharmacists who work in hospitals and health systems. With 40,000 members, ASHP is the largest pharmacy organization in the United States. Mustafa Lokhandwala, executive vice dean for research in the Department of Pharmacological and Pharmaceutical Sciences, states that such an honor would really boost the standards of UH. We are now a Tier One university and striving to maintain and achieve even higher standards, Lokhandwala said. Being recognized as a fellow of a society of professional organizations is really important because it adds to the stature of not only the College of Pharmacy but also that of the University of Houston. For about a decade, Garey … Continue reading

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In muscular dystrophy, what matters to patients and doctors can differ

Posted: Published on July 25th, 2012

Public release date: 25-Jul-2012 [ | E-mail | Share ] Contact: Mark Michaud mark_michaud@urmc.rochester.edu 585-273-4790 University of Rochester Medical Center Complex, multi-system diseases like myotonic dystrophy the most common adult form of muscular dystrophy require physicians and patients to identify which symptoms impact quality of life and, consequently, what treatments should take priority. However, a new study out this month in the journal Neurology reveals that there is often a disconnect between the two groups over which symptoms are more important, a phenomenon that not only impacts care but also the direction of research into new therapies. "In order to design better therapies we must first develop a clear understanding of what patients think are the key mental and physical burdens of this disease," said University of Rochester Medical Center (URMC) neurologist Chad Heatwole, M.D., lead author of the study. "It is clear from this study that, in the case of myotonic dystrophy, researchers have not always been concentrating on the symptoms that are most important to the patient." Myotonic dystrophy has been characterized as one of the most diverse and complex genetic diseases with a wide range of symptoms ranging from fatigue, muscle weakness, cognitive impairment, depression, difficulty sleeping, … Continue reading

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